文献

J-GLOBAL ID：201902229326380921   整理番号：19A0646492

多発性筋炎/皮膚筋炎関連間質性肺疾患の予測予後因子【JST・京大機械翻訳】

The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease

著者 (24件)： Sugiyama Yumiko (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Yoshimi Ryusuke (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Tamura Maasa (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Takeno Mitsuhiro (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Takeno Mitsuhiro (Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan) ,  Kunishita Yosuke (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Kishimoto Daiga (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Yoshioka Yuji (Yokohama Minami Kyosai Hospital, Yokohama, Japan) ,  Kobayashi Kouji (Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan) ,  Takase-Minegishi Kaoru (Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan) ,  Watanabe Toshiyuki (National Hospital Organization Yokohama Medical Center, Yokohama, Japan) ,  Hamada Naoki (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Nagai Hideto (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Tsuchida Naomi (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Soejima Yutaro (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Nakano Hiroto (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Kamiyama Reikou (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Uehara Takeaki (Chigasaki Municipal Hospital, Chigasaki, Japan) ,  Kirino Yohei (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan) ,  Sekiguchi Akiko (Fujisawa City Hospital, Fujisawa, Japan) ,  Ihata Atsushi (National Hospital Organization Yokohama Medical Center, Yokohama, Japan) ,  Ohno Shigeru (Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan) ,  Nagaoka Shouhei (Yokohama Minami Kyosai Hospital, Yokohama, Japan) ,  Nakajima Hideaki (Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan)
資料名： Arthritis Research & Therapy (Web)  (Arthritis Research & Therapy (Web))
巻： 20  号： 1  ページ： 7  発行年： 2018年 
JST資料番号： U7412A  ISSN： 1478-6362  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 間質性肺疾患(ILD)は,多発性筋炎/皮膚筋炎(PM/DM)における死亡の主な原因である。ここでは,多施設データベースを用いて,PM/DM-ILDにおける死亡および重篤な感染に対する予後因子を検討した。著者らは,PM/DM-ILD患者におけるベースライン人口統計学的,臨床的および臨床検査所見,治療レジメンおよび転帰を遡及的にレビューした。ILD病変の分布を,高分解能コンピュータ断層撮影画像の4分割肺領域で評価した。PM/DM-ILD患者116名のうち,14名は診断から6か月以内に死亡した。早期死亡に対する独立危険因子として,上部肺野における拡張ILD病変(オッズ比(OR)8.01,p=0.016)および低炭酸症(OR6.85,p=0.038)が同定された。重篤な感染は,呼吸器または複数の感染症で死亡した11人の患者を含む38人の患者で見つかった。独立危険因子は,高い血清KL-6(OR3.68,p=0.027),プレドニゾロン(PSL)の高い初期投与量(OR4.18,p=0.013)および併用免疫抑制療法(OR5.51,p<0.001)であった。本研究は,ベースラインにおけるILDの進行が生存のために最も重要であり,感染,特に呼吸器感染が強力な免疫抑制治療下の付加的予後因子であることを示す。Copyright 2019 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *多発性筋炎 ,  データベース ,  計算機トモグラフィー ,  血清 ,  *皮膚筋炎 ,  *予測 ,  治療法 ,  危険因子 ,  臨床検査 ,  呼吸器
準シソーラス用語： オッズ比 ,  病巣 ,  転帰 ,  レジメン ,  *予後因子 , 【Automatic Indexing@JST】

著者キーワード (3件)： 皮膚筋炎 ,  多発性筋炎 ,  間質性肺疾患

分類 (2件)： 呼吸器の疾患  (GI03000Z) ,  運動器系の疾患  (GG03000T)

引用文献 (36件)：

• Arthritis Rheum; Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis: a series of 107 patients; I Marie, PY Hatron, S Dominique, P Cherin, L Mouthon, JF Menard; 63; 11; 2011; 3439-3447; 10.1002/art.30513; citation_id=CR1
• Clin Rheumatol; Survival analysis of patients with dermatomyositis and polymyositis: analysis of 192 Chinese cases; KH Yu, YJ Wu, CF Kuo, LC See, YM Shen, HC Chang; 30; 12; 2011; 1595-1601; 10.1007/s10067-011-1840-0; citation_id=CR2
• Am J Respir Crit Care Med; An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias; WD Travis, U Costabel, DM Hansell, TE King, DA Lynch, AG Nicholson; 188; 6; 2013; 733-748; 10.1164/rccm.201308-1483ST; citation_id=CR3
• Medicine; Influence of age on characteristics of polymyositis and dermatomyositis in adults; I Marie, PY Hatron, H Levesque, E Hachulla, MF Hellot, U Michon-Pasturel; 78; 3; 1999; 139-147; 10.1097/00005792-199905000-00001; citation_id=CR4
• J Rheumatol; Longterm survival and associated risk factors in patients with adult-onset idiopathic inflammatory myopathies and amyopathic dermatomyositis: experience in a single institute in Japan; Y Yamasaki, H Yamada, M Ohkubo, M Yamasaki, K Azuma, H Ogawa; 38; 8; 2011; 1636-1643; 10.3899/jrheum.101002; citation_id=CR5

タイトルに関連する用語 (5件)： 多発性筋炎 ,  皮膚筋炎 ,  間質性肺疾患 ,  予測 ,  予後因子