文献

J-GLOBAL ID：201902266466683979   整理番号：19A2097361

絶食-再給餌は免疫細胞動態と粘膜免疫応答に影響する【JST・京大機械翻訳】

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

著者 (30件)： Nagai Motoyoshi (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Nagai Motoyoshi (Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan) ,  Noguchi Ryotaro (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Noguchi Ryotaro (Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan) ,  Takahashi Daisuke (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Morikawa Takayuki (Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan) ,  Koshida Kouhei (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Komiyama Seiga (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Ishihara Narumi (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Yamada Takahiro (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Kawamura Yuki I. (Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan) ,  Muroi Kisara (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Hattori Kouya (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Kobayashi Nobuhide (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Fujimura Yumiko (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Hirota Masato (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Matsumoto Ryohtaroh (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Aoki Ryo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Aoki Ryo (Institute of Health Sciences, Ezaki Glico Co., Ltd., Osaka 555-8502, Japan) ,  Tamura-Nakano Miwa (Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan) ,  Sugiyama Machiko (Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan) ,  Sugiyama Machiko (Laboratory for Immunobiology, Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-045, Japan) ,  Katakai Tomoya (Department of Immunology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan) ,  Sato Shintaro (Mucosal Vaccine Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan) ,  Sato Shintaro (International Research and Development Center for Mucosal Vaccines, the Institute of Medical Science, the University of Tokyo (IMSUT), Tokyo 108-8639, Japan) ,  Takubo Keiyo (Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan) ,  Dohi Taeko (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Dohi Taeko (Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan) ,  Hase Koji (Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan) ,  Hase Koji (International Research and Development Center for Mucosal Vaccines, the Institute of Medical Science, the University of Tokyo (IMSUT), Tokyo 108-8639, Japan)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 178  号： 5  ページ： 1072-1087.e14  発行年： 2019年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 栄養状態は免疫応答に影響する可能性がある;しかしながら,栄養シグナルが細胞動力学と機能性をどのように調節するかは不明のままである。ここでは,一時的な絶食が,腸免疫反応の誘導部位であるPeyerパッチ(PP)において約50%までリンパ球数を劇的に減少させることを報告する。その後の再給餌はリンパ球数を回復させたが,細胞組成は顕著に変化した。胚中心とIgA+B細胞の大部分は,絶食の間,アポトーシスを通して失われた。一方,ナイーブB細胞は絶食時にPPsから骨髄に移動し,間質細胞が栄養シグナルを感知し,CXCL13発現をアップレギュレーションしてナイーブB細胞を動員する時に再給餌時にPPsに戻った。さらに,卵白アルブミンによる経口免疫前の時間的絶食は抗原特異的IgAの誘導を消失させ,経口耐性を誘導することができず,最終的に食物抗原誘発下痢を悪化させた。したがって,栄養シグナルは腸の免疫ホメオスタシスの維持に重要である。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 卵白アルブミン ,  骨髄 ,  *粘膜免疫 ,  抗原 ,  下痢 ,  免疫グロブリンA ,  アポトーシス ,  アップレギュレーション ,  栄養状態 ,  ホメオスタシス ,  *絶食 ,  経口免疫 ,  *細胞運命 ,  *再給餌 ,  シグナル伝達
準シソーラス用語： 細胞情報伝達 , 【Automatic Indexing@JST】

著者キーワード (11件)： 免疫代謝 ,  Peyerのパッチ ,  骨髄 ,  B細胞 ,  CXCL13 ,  粘膜免疫 ,  栄養シグナル ,  絶食 ,  間質細胞 ,  mTORシグナル伝達 ,  IgA

分類 (1件)： 細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： 絶食 ,  再給餌 ,  免疫 ,  細胞動態 ,  粘膜免疫応答