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J-GLOBAL ID：202002214061385315   整理番号：20A1172790

腫瘍エキソソームCemIP蛋白質は脳転移における癌細胞コロニー形成を促進する【JST・京大機械翻訳】

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

著者 (59件)： Rodrigues Goncalo (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Rodrigues Goncalo (Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal) ,  Hoshino Ayuko (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hoshino Ayuko (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan) ,  Hoshino Ayuko (JST, PRESTO, Tokyo, Japan) ,  Kenific Candia M. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Matei Irina R. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Steiner Loiec (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Steiner Loiec (Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland) ,  Freitas Daniela (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Freitas Daniela (i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal) ,  Freitas Daniela (IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal) ,  Freitas Daniela (Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), University of Porto, Porto, Portugal) ,  Kim Han Sang (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Kim Han Sang (Yonsei Cancer Center, Division of Medical Oncology, Departments of Internal Medicine, and Pharmacology, Yonsei University College of Medicine, Seoul, Korea) ,  Oxley Peter R. (Samuel J. Wood Library, Weill Cornell Medicine, New York, NY, USA) ,  Scandariato Ilana (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Casanova-Salas Irene (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Dai Jinxiang (Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Badwe Chaitanya R. (Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Gril Brunilde (Woman’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ,  Tesic Mark Milica (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Dill Brian D. (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Molina Henrik (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Zhang Haiying (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Benito-Martin Alberto (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Bojmar Linda (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Ararso Yonathan (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Offer Katharine (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  LaPlant Quincey (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Buehring Weston (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Wang Huajuan (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Jiang Xinran (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Lu Tyler M. (Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Lu Tyler M. (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility, Weill Cornell Medicine (WCM), New York, NY, USA) ,  Liu Yuan (Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Sabari Joshua K. (Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Shin Sandra J. (Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Narula Navneet (Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Ginter Paula S. (Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Rajasekhar Vinagolu K. (Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, USA) ,  Healey John H. (Orthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Meylan Etienne (Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland) ,  Costa-Silva Bruno (Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal) ,  Wang Shizhen Emily (Department of Pathology, University of California, San Diego, La Jolla, CA, USA) ,  Rafii Shahin (Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Altorki Nasser Khaled (Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA) ,  Rudin Charles M. (Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Jones David R. (Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Steeg Patricia S. (Woman’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ,  Peinado Hector (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Peinado Hector (Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain) ,  Ghajar Cyrus M. (Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Bromberg Jacqueline (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Bromberg Jacqueline (Department of Medicine, Weill Cornell Medicine, New York, NY, USA) ,  de Sousa Maria (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  de Sousa Maria (Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal) ,  Pisapia David (Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Lyden David (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA)
資料名： Nature Cell Biology  (Nature Cell Biology)
巻： 21  号： 11  ページ： 1403-1412  発行年： 2019年 
JST資料番号： W1369A  ISSN： 1465-7392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 脳転移に対する有効な治療法の開発は,現在,それを駆動する分子機構の理解における限界により妨げられている。ここでは,脳転移コロニー形成に対する腫瘍分泌エキソソームの寄与を定義し,脳転移細胞からのエキソソームによる脳微小環境のプレコンディショニングが癌細胞増殖を増強することを示した。プロテオーム解析により,細胞移動誘導およびヒアルロン酸結合蛋白質(CEMIP)が,脳転移からのエキソソームにおいて上昇したが,肺または骨転移細胞ではないことを同定した。腫瘍細胞におけるCEMIP枯渇は脳転移を障害し,脳血管系との浸潤および腫瘍細胞関連を破壊し,CEMIP+エキソソームによる脳微小環境の前処理により表現型を救済した。さらに,脳内皮細胞およびミクログリア細胞によるCEMIP+エキソソームの取り込みは,脳血管リモデリングおよび転移を促進することが知られているPtgs2,TnfおよびCcl/CXCLによりコードされる炎症誘発性サイトカインを上方制御することにより血管周囲ニッチに内皮細胞分枝および炎症を誘導した。CEMIPは,脳転移を有する患者から腫瘍組織とエキソソームにおいて上昇して,脳転移進行と患者生存を予測した。まとめると,著者らの知見は,標的エキソソームCEMIPが脳転移の予防と治療のための将来の道を構成できることを示唆する。Rodriguesらは,脳転移細胞から誘導されたエキソソームCEMIPが血管リモデリングと炎症を誘発し,その後の脳微小環境における転移性コロニー形成を支持することを示す。Copyright The Author(s), under exclusive licence to Springer Nature Limited 2019 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 炎症 ,  *腫瘍 ,  *腫瘍細胞 ,  表現型 ,  内皮細胞 ,  アップレギュレーション ,  細胞移動 ,  血管リモデリング
準シソーラス用語： 分子機構 ,  微小環境 ,  *コロニー形成 ,  *エキソソーム ,  骨転移 ,  プロテオーム解析 ,  *脳転移 , 【Automatic Indexing@JST】

分類 (2件)： 生物学的機能  (EB03040U) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (8件)： 腫瘍 ,  エキソソーム ,  CEMIP ,  蛋白質 ,  脳転移 ,  癌細胞 ,  コロニー形成 ,  促進