文献

J-GLOBAL ID：202002214613291120   整理番号：20A0781898

分泌間質蛋白質ISLRは上皮Hippoシグナル伝達を抑制することにより腸再生を促進する【JST・京大機械翻訳】

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling

著者 (25件)： Xu Jiuzhi (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Xu Jiuzhi (Guangdong Provincial Key Laboratory of Regional Immunity and School of Medicine, Shenzhen University, Shenzhen, China) ,  Tang Yang (State Key Laboratories of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China) ,  Tang Yang (Postdoctoral Station of Clinical Medicine, Shanghai Tenth Peoples Hospital, Tongji University School of Medicine, Shanghai, China) ,  Sheng Xiaole (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Tian Yuhua (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Deng Min (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Du Sujuan (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Lv Cong (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Lv Cong (Guangdong Provincial Key Laboratory of Regional Immunity and School of Medicine, Shenzhen University, Shenzhen, China) ,  Li Guili (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Pan Yuwei (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Song Yongli (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Lou Pengbo (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Luo Yongting (Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China) ,  Li Yuan (Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China) ,  Zhang Bing (College of Veterinary Medicine, China Agricultural University, Beijing, China) ,  Chen Yanmei (State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Liu Zhanju (Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China) ,  Cong Yingzi (Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA) ,  Plikus Maksim V (Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA) ,  Meng Qingyong (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China) ,  Zhou Zhaocai (State Key Laboratories of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China) ,  Zhou Zhaocai (Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China) ,  Yu Zhengquan (State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China)
資料名： EMBO Journal  (EMBO Journal)
巻： 39  号： 7  ページ： e103255  発行年： 2020年 
JST資料番号： A0911B  ISSN： 0261-4189  CODEN： EMJODG  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： Hippo-YAPシグナル伝達経路は,腸の再生と腫瘍形成の間,上皮細胞において重要な役割を果たす。しかしながら,YAP仲介腸再生および腫瘍形成に対する間質シグナルを結びつける分子機構は,あまり明らかにされていない。ここでは,腸再生および腫瘍形成時の上皮細胞増殖を調節する間質細胞に必須な間質上皮ISLR-YAPシグナリング軸を報告する。特に,炎症と癌において,間質細胞における発癌性転写因子ETS1は,Hippoシグナル伝達を阻害し,上皮細胞においてYAPを活性化する分泌蛋白質ISLRの発現を誘導する。マウスの間質細胞におけるISLRの欠失は腸の再生を著しく損ない,結腸の腫瘍形成を抑制した。さらに,間質細胞特異的ISLRおよびETS1の発現は,ヒトIBD患者の炎症粘膜およびヒト結腸直腸腺癌において有意に増加し,上皮YAP過活性化を説明した。まとめると,著者らの知見は,組織再生と腫瘍形成の間質と上皮の間のシグナル伝達クロストークへの新しい洞察を提供する。Copyright 2020 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *間質組織 ,  結腸 ,  分泌タンパク質 ,  腫瘤形成 ,  間質細胞 ,  転写因子 ,  *細胞情報伝達 ,  腺癌 ,  粘膜 ,  ヒト ,  上皮細胞 ,  炎症 ,  *上皮 ,  クロストーク
準シソーラス用語： *Hippo蛋白質 , 【Automatic Indexing@JST】

著者キーワード (5件)： 大腸癌 ,  Hippoシグナル伝達 ,  腸再生 ,  ISLR ,  間質-上皮クロストーク

分類 (2件)： 細胞構成体の機能  (EF03060C) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (8件)： 分泌 ,  間質 ,  蛋白質 ,  上皮 ,  Hippo ,  シグナル伝達 ,  腸 ,  促進