文献

J-GLOBAL ID：202002218065220580   整理番号：20A1762150

Clustered regularly interspaced short palindromic repeats(CRISPR)とCas9による新たなIl2rg-ノックアウトマウスの作出

Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9

著者 (15件)： Byambaa Suvd (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hara Hiromasa (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hara Hiromasa (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nagao Yasumitsu (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nagao Yasumitsu (Center for Experimental Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Ohmori Tsukasa (Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan)
資料名： Experimental Animals (Web)  (Experimental Animals (Web))
巻： 69  号： 2  ページ： 189-198(J-STAGE)  発行年： 2020年 
JST資料番号： U2149A  ISSN： 1881-7122  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： X連鎖重症複合免疫不全(X-linked severe co...

シソーラス用語： マウス ,...
準シソーラス用語： *CRISPR-Cas9システム ,...

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著者キーワード (5件)： 動物モデル ,  クラスター化規則的間隔間短パリンドローム反復(CRISPR)/Cas9 ,  ゲノム編集 ,  II2rg ,  X連鎖重症複合免疫不全(X-SCID)

分類 (4件)： 先天性疾患・奇形一般  (GD03010V) ,  免疫性疾患・アレルギー性疾患一般  (GD04010C) ,  遺伝学研究法  (EC01020N) ,  実験用生物  (EA03070Y)

引用文献 (36件)：

• 1. Bae S., Park J. and Kim J.S. 2014. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases. Bioinformatics 30: 1473-1475.
• 2. Birling M.C., Herault Y. and Pavlovic G. 2017. Modeling human disease in rodents by CRISPR/Cas9 genome editing. Mamm. Genome 28: 291-301.
• 3. Cao X., Shores E.W., Hu-Li J., Anver M.R., Kelsall B.L., Russell S.M., Drago J., Noguchi M., Grinberg A., Bloom E.T., Pau L.W.E., Katz S.I., Love P.E. and Leonard W.J. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2: 223-238.
• 4. Cavazzana-Calvo M., Hacein-Bey S., de Saint Basile G., Gross F., Yvon E., Nusbaum P., Selz F., Hue C., Certain S., Casanova J.L., Bousso P., Deist F.L. and Fischer A. 2000. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288: 669-672.
• 5. Chang C.W., Lai Y.S., Westin E., Khodadadi-Jamayran A., Pawlik K.M., Lamb L.S. Jr., Goldman F.D. and Townes T.M. 2015. Modeling human severe combined immunodeficiency and correction by CRISPR/Cas9-enhanced gene targeting. Cell Rep. 12: 1668-1677.

タイトルに関連する用語 (3件)： CRISPR ,  Cas9 ,  ノックアウトマウス