文献

J-GLOBAL ID：202002218641932229   整理番号：20A0707967

血清TGabの存在は全国調査からの甲状腺機能正常集団におけるグルコースおよび脂質代謝障害の低リスクを示唆する【JST・京大機械翻訳】

The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey

著者 (39件)： Zhang Jinjia (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Gao Yiyang (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Li Yongze (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Teng Di (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Xue Yuanming (Department of Endocrinology, The First People’s Hospital of Yunnan Province, Kunming, China) ,  Yan Li (Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China) ,  Yang Jing (Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China) ,  Yang Lihui (Department of Endocrinology and Metabolism, People’s Hospital of Tibet Autonomous Region, Lhasa, China) ,  Yao Yongli (Department of Endocrinology, Qinghai Provincial People’s Hospital, Xining, China) ,  Ba Jianming (Department of Endocrinology, Chinese PLA General Hospital, Beijing, China) ,  Chen Bing (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China) ,  Du Jianling (Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China) ,  He Lanjie (Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China) ,  Lai Xiaoyang (Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China) ,  Teng Xiaochun (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Shi Xiaoguang (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Li Yanbo (Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China) ,  Chi Haiyi (Department of Endocrinology, Hohhot First Hospital, Hohhot, China) ,  Liao Eryuan (Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China) ,  Liu Chao (Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China) ,  Liu Libin (Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China) ,  Qin Guijun (Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Qin Yingfen (Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China) ,  Quan Huibiao (Department of Endocrinology, Hainan General Hospital, Haikou, China) ,  Shi Bingyin (Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China) ,  Sun Hui (Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Tang Xulei (Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China) ,  Tong Nanwei (State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China) ,  Wang Guixia (Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China) ,  Zhang Jin-an (Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China) ,  Wang Youmin (Department of Endocrinology, The First Hospital of Anhui Medical University, Hefei, China) ,  Ye Zhen (Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China) ,  Zhang Qiao (Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China) ,  Zhang Lihui (Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China) ,  Zhu Jun (Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, UEruemqi, China) ,  Zhu Mei (Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China) ,  Teng Weiping (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Shan Zhongyan (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Li Jing (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China)
資料名： Frontiers in Endocrinology (Web)  (Frontiers in Endocrinology (Web))
巻： 11  ページ： 139  発行年： 2020年 
JST資料番号： U7068A  ISSN： 1664-2392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 目的:甲状腺ペルオキシダーゼ(TPOAb)およびチログロブリン(TgAb)に対する抗体の発現は,自己免疫性甲状腺疾患(AITD)患者の血清において非常に一般的である。甲状腺自己抗体とグルコースと脂質代謝障害の発生の間の関係は不明のままである。本研究は,甲状腺機能正常集団における血清TPOAB/TgAbの存在とそれらの代謝障害の間の相関を調査するために行われた。【方法】:本研究のデータは,中国本土のすべての31の省からの甲状腺疾患,ヨウ素状態,および糖尿病国家疫学(TIDE)調査から得られた。本研究において,5,802人の男性(TPOAb~TgAb~-および1,802のTPOAb+/TgAb+)および12162人の女性(TPOAb~TgAb~-および4162のTPOAb+/TgAb+)を含む合計17964人の甲状腺機能を登録した。血中グルコースと脂質レベルを,TPOAb-TgAb-とTPOAb+TgAb-,TPOAb-TgAb+,TPOAb+TgAb+との間で比較した。結果:空腹時血糖(FBG)濃度と障害されたFBG(IFG)を有する個人の割合は,TPOAb~TgAb~Menと比較して,TPOAb~TgAb+男性における減少傾向を示した。TPOAb~TgAb+女性と比較して,TPOAb~TgAb+女性におけるIGTおよび高トリグリセリド血症の発生率の減少傾向と同様に,FBGおよびHDL-Cレベルが有意に低かった。さらに,二成分ロジスティック回帰分析により,男性における血清TgAb単一陽性はIFGに対する独立保護因子であり,ORは0.691(95%CI,0.503~0.949)であることを示した。女性では,血清TgAb単一陽性は高トリグリセリド血症の独立した保護因子であり,ORは0.859(95%CI,0.748~0.987)であった。傾向試験は,血清TgAbレベルの増加によって,特に非肥満女性の間で,女性におけるTSH≦2.5mIU/Lと高トリグリセリド血症の男性の間でIFGの罹患率において有意な減少があったことを示した。結論:血清TgAb単一陽性は,甲状腺機能亢進症男性におけるIFGのリスクの低下と甲状腺機能亢進症女性における高トリグリセリド血症のリスクの減少を意味する可能性がある。TgAbの独立した保護的役割の機構はさらなる研究を待つ。Copyright 2020 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： HDLコレステロール ,  *血清 ,  脂質 ,  *代謝異常 ,  *甲状腺 ,  ヨウ素 ,  チログロブリン ,  疫学 ,  甲状腺機能亢進症 ,  高トリグリセリド血症 ,  抗体 ,  甲状腺疾患 ,  ペルオキシダーゼ ,  血糖 ,  糖尿病 ,  ペルオキシドオキシドレダクターゼ

著者キーワード (6件)： グルコース ,  脂質 ,  TPOAB ,  TGAB ,  IFG ,  高トリグリセリド血症

分類 (2件)： 内分泌系の診断  (GL02000B) ,  内分泌系の疾患  (GL03000I)

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タイトルに関連する用語 (7件)： 血清 ,  調査 ,  甲状腺機能 ,  集団 ,  グルコース ,  脂質代謝障害 ,  リスク