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J-GLOBAL ID：202002230746517706   整理番号：20A1038836

Nrf2抗酸化経路の季節的変化は冬のうつ病様行動を調節する【JST・京大機械翻訳】

Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior

著者 (42件)： Nakayama Tomoya (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Nakayama Tomoya (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Nakayama Tomoya (Division of Seasonal Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Aichi, Japan) ,  Okimura Kousuke (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Okimura Kousuke (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Shen Jiachen (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Shen Jiachen (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Guh Ying-Jey (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Guh Ying-Jey (Division of Seasonal Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Aichi, Japan) ,  Tamai T. Katherine (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Shimada Akiko (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Shimada Akiko (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Minou Souta (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Minou Souta (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Okushi Yuki (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Okushi Yuki (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Shimmura Tsuyoshi (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Shimmura Tsuyoshi (Division of Seasonal Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Aichi, Japan) ,  Furukawa Yuko (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Kadofusa Naoya (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Sato Ayato (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Nishimura Toshiya (Graduate School of Science, Nagoya University, 464-8601 Nagoya, Japan) ,  Tanaka Minoru (Graduate School of Science, Nagoya University, 464-8601 Nagoya, Japan) ,  Nakayama Kei (Laboratory of Neuronal Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Japan) ,  Nakayama Kei (Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan) ,  Nakayama Kei (Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 444-8787 Okazaki, Aichi, Japan) ,  Shiina Nobuyuki (Laboratory of Neuronal Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Japan) ,  Shiina Nobuyuki (Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan) ,  Shiina Nobuyuki (Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 444-8787 Okazaki, Aichi, Japan) ,  Yamamoto Naoyuki (Laboratory of Fish Biology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Loudon Andrew S. (Centre for Biological Timing, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, M13 9PL Manchester, United Kingdom) ,  Nishiwaki-Ohkawa Taeko (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Nishiwaki-Ohkawa Taeko (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Shinomiya Ai (Division of Seasonal Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Aichi, Japan) ,  Shinomiya Ai (Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), 444-8585 Okazaki, Japan) ,  Shinomiya Ai (Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 444-8787 Okazaki, Aichi, Japan) ,  Nabeshima Toshitaka (Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, 470-1192 Toyoake, Aichi, Japan) ,  Nakane Yusuke (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Nakane Yusuke (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Yoshimura Takashi (Institute of Transformative Bio-Molecules (ITbM), Nagoya University, 464-8601 Nagoya, Japan) ,  Yoshimura Takashi (Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan) ,  Yoshimura Takashi (Division of Seasonal Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 444-8585 Okazaki, Aichi, Japan)
資料名： Proceedings of the National Academy of Sciences of the United States of America  (Proceedings of the National Academy of Sciences of the United States of America)
巻： 117  号： 17  ページ： 9594-9603  発行年： 2020年 
JST資料番号： D0387A  ISSN： 0027-8424  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 環境における季節的変化は,ヒトおよび動物における抑制様行動をもたらす。しかし,基礎となる機構は不明である。著者らは,冬のような条件に曝露されたメダカ魚において,社会性の低下と不安様行動の増加を観察した。全脳代謝分析により,神経伝達物質と抑制剤を含む68の代謝産物の季節的変化が明らかになった。トランスクリプトーム解析により,炎症マーカー,メラノプシン,及び概日時計遺伝子を含む3306の差別的に発現した転写産物を同定した。更なる分析は,核因子赤血球由来2様2(NRF2)抗酸化経路を含む,欝病に関わる複数のシグナリング経路の季節的変化を明らかにした。広いスペクトル化学スクリーンは,セラストロール(伝統的漢方薬)が冬の行動をユニークに逆転させることを明らかにした。Nrf2は,うつ病の病態生理において重要な役割を果たすことが知られている,ハブナラ(HB)で発現されるセラストロール標的である。もう一つのNRF2化学活性化因子はこれらの効果を表現し,NRF2変異体は減少した社会性を示した。著者らの研究は,冬のうつ病に対する重要な洞察を提供し,NRF2を含む潜在的な治療標的を提供する。Copyright 2020 The Author(s). Published by PNAS. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 赤血球 ,  スクリーン ,  遺伝子 ,  神経伝達物質 ,  代謝産物 ,  ヒト ,  *冬 ,  スペクトル ,  メダカ ,  *うつ病 ,  抑制剤 ,  漢方製剤 ,  転写産物 ,  概日時計 ,  カダヤシ目
準シソーラス用語： 治療標的 , 【Automatic Indexing@JST】

著者キーワード (5件)： 季節性感情障害 ,  冬のうつ病 ,  メダカ ,  概日リズム ,  化学ゲノミクス

分類 (2件)： 精神科の基礎医学  (GR01020I) ,  神経の基礎医学  (GN01020W)

タイトルに関連する用語 (8件)： NRF2 ,  酸化 ,  経路 ,  季節的変化 ,  冬 ,  うつ病 ,  行動 ,  調節