文献

J-GLOBAL ID：202102222415739305   整理番号：21A0195426

「2ヒット」ストレッサーモデルにおけるストレス対処行動および認知パフォーマンスに対する土壌由来細菌Mycobacterium vaccaeによる免疫の影響【JST・京大機械翻訳】

Effects of Immunization With the Soil-Derived Bacterium Mycobacterium vaccae on Stress Coping Behaviors and Cognitive Performance in a “Two Hit” Stressor Model

著者 (69件)： Foxx Christine L. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Foxx Christine L. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Heinze Jared D. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Heinze Jared D. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Gonzalez Antonio (Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States) ,  Vargas Fernando (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Vargas Fernando (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States) ,  Baratta Michael V. (Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Baratta Michael V. (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Elsayed Ahmed I. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Elsayed Ahmed I. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Stewart Jessica R. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Stewart Jessica R. (Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Loupy Kelsey M. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Loupy Kelsey M. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Arnold Mathew R. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Arnold Mathew R. (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Flux M. C. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Flux M. C. (Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Sago Saydie A. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Sago Saydie A. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Siebler Philip H. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Milton Lauren N. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Lieb Margaret W. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Hassell James E. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Hassell James E. (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Smith David G. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Lee Kyo A. K. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Lee Kyo A. K. (Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Appiah Sandra A. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Appiah Sandra A. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Schaefer Evan J. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Schaefer Evan J. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Panitchpakdi Morgan (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Panitchpakdi Morgan (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States) ,  Sikora Nicole C. (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Sikora Nicole C. (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States) ,  Weldon Kelly C. (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Weldon Kelly C. (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States) ,  Stamper Christopher E. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Schmidt Dominic (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Duggan David A. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Mengesha Yosan M. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Ogbaselassie Mikale (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Nguyen Kadi T. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Gates Chloe A. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Schnabel K’loni (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Tran Linh (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Jones Joslynn D. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Vitaterna Martha H. (Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, United States) ,  Turek Fred W. (Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, United States) ,  Fleshner Monika (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Fleshner Monika (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Dorrestein Pieter C. (Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States) ,  Dorrestein Pieter C. (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Dorrestein Pieter C. (Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States) ,  Knight Rob (Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States) ,  Knight Rob (Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, United States) ,  Knight Rob (Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States) ,  Knight Rob (Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States) ,  Wright Kenneth P. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Wright Kenneth P. (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Lowry Christopher A. (Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States) ,  Lowry Christopher A. (Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, United States) ,  Lowry Christopher A. (Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States) ,  Lowry Christopher A. (Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, United States) ,  Lowry Christopher A. (Military and Veteran Microbiome: Consortium for Research and Education, Aurora, CO, United States) ,  Lowry Christopher A. (Department of Physical Medicine and Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO, United States) ,  Lowry Christopher A. (inVIVO Planetary Health, Worldwide Universities Network, West New York, NJ, United States)
資料名： Frontiers in Physiology (Web)  (Frontiers in Physiology (Web))
巻： 11  ページ： 524833  発行年： 2020年 
JST資料番号： U7093A  ISSN： 1664-042X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 以前の研究は,抗炎症および免疫調節特性を有する土壌由来細菌であるMycobacterium vaccae NCTC11659(M.vaccae)が,ストレッサーに対する陰性転帰に対する潜在的に有用な対策であることを示した。ここでは,雄のC57BL/6NCrlマウスを用い,M.vaccaeによる反復免疫がリズムの慢性破壊(CDR)の「2ヒット」ストレス曝露モデルにおける効果的な対策であり,続いて急性の社会的デファット(SD)であるかどうかを決定した。28日目に,マウスは運動活動の24時間リズムをモニターするために生体測定記録装置のインプラントを受けた。その後,マウスはM.vaccae(0.1mg,-21,-14,-7,および27)またはホウ酸塩緩衝生理食塩水ビークルの加熱殺菌調製で治療された。次に,マウスは,安定正常12:12h光:暗(LD)条件またはCDRのいずれかの8連続週に曝露され,7日(0~56日)毎にLDサイクルの12時間反転から成る。最後に,マウスは,54日目に10分SDまたは家庭ケージ制御条件のいずれかに曝露した。すべてのマウスは,SDの24時間後に対象位置記憶試験にさらされた。16S rRNA遺伝子配列およびLC-MS/MSスペクトルデータを用いて,それぞれ,1日目,48日目および62日目に採取した糞便試料で,腸ミクロビオームおよびメタボロームを評価した。血漿メタボロームは,さらに64日目に測定した。正常LD条件に曝露したマウスの中で,M.vaccaeによる免疫は,SDに対するより積極的な行動コーピング応答へのシフトを誘導し,これは,スカウティングの増加および接近する雄のCD-1攻撃者の回避により測定され,また,サブミティブな直立防御姿勢の低下により低下した。” S.vaccae]は,SDに対するより前向きな行動コーピング反応へのシフトを誘導した。” S.vaccaeによる免疫は,SDに対するより前向きな行動コーピング反応へのシフトを誘導した。対象位置記憶試験において,SDへの曝露は以前にM.vaccaeで免疫したCDRマウスの認知機能を増加させた。M.vaccaeによる免疫は,腸ミクロビオームを安定化させ,α多様性のCDR誘導減少を軽減し,β多様性のグループ内測定を減少させた。M.vaccaeによる免疫は,血漿中の1-ヘプタデカノイル-sn-グリセロ-3-ホスホコリン,リゾリン脂質の相対存在量も増加させた。まとめると,これらのデータは,M.vaccaeによる免疫が腸ミクロビオームを安定化させ,ストレス曝露に対するより積極的な応答へのシフトを誘導し,ストレスレジリエンスを促進するという仮説を支持する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 生体計測 ,  記録装置 ,  血漿 ,  *細菌 ,  ホウ酸塩 ,  消炎作用 ,  レジリエンス ,  保持器 ,  加熱殺菌 ,  リゾリン脂質
準シソーラス用語： LC/MS/MS ,  ストレスコーピング ,  *ストレッサー ,  常在菌叢ゲノム , 【Automatic Indexing@JST】

著者キーワード (8件)： 認知 ,  日周 ,  運動活動 ,  メタボローム ,  マイクロバイオーム ,  マイクロバイオーム-腸-脳軸 ,  微生物叢 ,  ストレス回復力

分類 (1件)： 神経の基礎医学  (GN01020W)

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タイトルに関連する用語 (7件)： ストレス対処行動 ,  認知 ,  パフォーマンス ,  土壌 ,  細菌 ,  Mycobacterium ,  免疫