文献

J-GLOBAL ID：202102248140396401   整理番号：21A0014301

虚血再灌流障害の齧歯類モデルにおけるPanax Notoginsengによって誘発される遺伝子【JST・京大機械翻訳】

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury

著者 (46件)： Meng Lanqing (Jinan University, Guangzhou City, Guangdong Province, China) ,  Meng Lanqing (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Qing (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Qing (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Li Xuebin (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Liang Ping (Department of Neurology, The First People’s Hospital of Yulin, Yulin City, Guangxi Province, China) ,  Li Yueyong (Department of Inverventional Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Xiaohua (Jinan University, Guangzhou City, Guangdong Province, China) ,  Huang Xiaohua (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Zhao Jingjie (Life Science and Clinical Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Chen Qiuping (Department of Rehabilitation Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Qiu Rong (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Qiu Rong (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Qiu Rong (Urinary Surgery Department, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Li Lan (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Li Lan (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Jian Chongdong (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Yao Hongfei (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Jianmin (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Tang Xionglin (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wang Zechen (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wang Zechen (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Zhongheng (Department of Inverventional Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Zhongheng (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wu Jun (Urinary Surgery Department, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Liuzhi (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Liuzhi (College of Pharmacy, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Qiuju (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Qiuju (College of Pharmacy, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Tang Qianli (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Lu (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Lu (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Huang Lu (Urinary Surgery Department, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Wei Jihua (Trauma Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Lu Dinggui (Trauma Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Luo Qunqiang (Trauma Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Xie Kegong (Trauma Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Ouyang Yang (Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Chen Jian (Graduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Chen Jian (Trauma Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Li Genliang (Department of Biochemistry and Molecular Biology, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Luo Linxue (Department of Gynaecology and Obstetrics, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  He Linbo (Shangsi People’s Hospital, Fangchenggang City, Guangxi Province, China) ,  Zhuo Chenyi (Department of Hepatological Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China) ,  Xu Anding (Jinan University, Guangzhou City, Guangdong Province, China) ,  Meng Lingzhang (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, China)
資料名： Journal of Immunology Research (Web)  (Journal of Immunology Research (Web))
巻： 2020  ページ： Null  発行年： 2020年 
JST資料番号： U7019A  ISSN： 2314-8861  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 脳卒中は血流低下をもたらす脳血管疾患である。漢方薬であるPanax notoginseng(PN)は脳卒中回復を促進することが証明されているが,その分子機構は不明である。この研究では,中大脳動脈閉塞(MCAO)を,スレッドにより発生した血栓のラットで誘導し,続いてPNで治療した。その後,2,3,5-トリフェニレテトラゾールイウムクロリドによる染色を用いて梗塞領域を評価し,電子顕微鏡を用いて神経血管単位の超微細構造変化を評価した。RNA-Seqを,qPCRによって次に検証された差次的発現遺伝子(DEG)を測定するために実行した。全体で,817のDEGが脳卒中回復に対するPNの治療効果に関連すると同定された。Gene Oncology分析とGenesとGenomesの京都Encycopediaによるさらなる分析は,これらの遺伝子の大部分は,PI3K-Akt,Rap1,cAMP,およびcGMP-PKGシグナル伝達の神経活性生体受容体相互作用の調節を通して神経と血管の生物学的機能に関与し,そのうち9つはPNの神経保護効果に関連することを初めて報告した。本研究は,脳卒中回復に対するPNの影響の基礎となる潜在的分子機構に光を当てる。Copyright 2020 Lanqing Meng et al. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  電子顕微鏡 ,  血管 ,  RNA【核酸】 ,  *遺伝子 ,  血栓症 ,  ラット ,  生物活性 ,  *齧歯類 ,  脳卒中 ,  漢方製剤 ,  *トチバニンジン属 ,  定量的PCR法 ,  分子機構 ,  シグナル伝達 ,  血栓塞栓症 ,  ネズミ亜目 ,  *哺乳類
準シソーラス用語： 細胞情報伝達 , 【Automatic Indexing@JST】

分類 (2件)： 神経の基礎医学  (GN01020W) ,  免疫反応一般  (ED03010T)

引用文献 (36件)：

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タイトルに関連する用語 (6件)： 虚血再灌流障害 ,  齧歯類 ,  モデル ,  Panax ,  誘発 ,  遺伝子