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J-GLOBAL ID：202102287888447097   整理番号：21A0265253

アルツハイマー病および非Alzheimer病タウオパシーにおけるタウ病理のin vivoイメージング【JST・京大機械翻訳】

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

著者 (50件)： Tagai Kenji (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Tagai Kenji (Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan) ,  Ono Maiko (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kubota Manabu (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kubota Manabu (Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan) ,  Kitamura Soichiro (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kitamura Soichiro (Department of Psychiatry, Nara Medical University, Nara 634-8521, Japan) ,  Takahata Keisuke (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Takahata Keisuke (Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan) ,  Seki Chie (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Takado Yuhei (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Shinotoh Hitoshi (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Shinotoh Hitoshi (Neurology Clinic Chiba, Chiba 263-8555, Japan) ,  Sano Yasunori (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Sano Yasunori (Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan) ,  Yamamoto Yasuharu (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Yamamoto Yasuharu (Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan) ,  Matsuoka Kiwamu (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Matsuoka Kiwamu (Department of Psychiatry, Nara Medical University, Nara 634-8521, Japan) ,  Takuwa Hiroyuki (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Shimojo Masafumi (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Takahashi Manami (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kawamura Kazunori (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kikuchi Tatsuya (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Okada Maki (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Akiyama Haruhiko (Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Suzuki Hisaomi (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Suzuki Hisaomi (Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan) ,  Suzuki Hisaomi (National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, Japan) ,  Onaya Mitsumoto (National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, Japan) ,  Takeda Takahiro (Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan) ,  Arai Kimihito (Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan) ,  Arai Nobutaka (Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Araki Nobuyuki (Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan) ,  Saito Yuko (National Center of Neurology and Pathology Brain Bank, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan) ,  Trojanowski John Q. (Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Lee Virginia M.Y. (Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Mishra Sushil K. (Glycoscience Group, National University of Ireland, Galway H91 W2TY, Ireland) ,  Yamaguchi Yoshiki (Laboratory of Pharmaceutical Physical Chemistry, Tohoku Medical and Pharmaceutical University, Miyagi 981-8558, Japan) ,  Kimura Yasuyuki (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Kimura Yasuyuki (Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan) ,  Ichise Masanori (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Tomita Yutaka (Tomita Hospital, Aichi 444-3505, Japan) ,  Zhang Ming-Rong (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Suhara Tetsuya (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Suhara Tetsuya (Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan) ,  Shigeta Masahiro (Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan) ,  Sahara Naruhiko (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Higuchi Makoto (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Shimada Hitoshi (National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan)
資料名： Neuron  (Neuron)
巻： 109  号： 1  ページ： 42-58.e8  発行年： 2021年 
JST資料番号： T0649A  ISSN： 0896-6273  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 放射化学のパネルはAlzheimer病(AD)におけるタウ病理のin vivo陽電子放出断層撮影(PET)を可能にしているが,前頭側頭葉変性(FTLD)タウ封入体の高感度検出は成功していない。ここでは,多様なタウ沈着物を捕捉するためのイメージングプローブPM-PBB3を作成した。in vitroアッセイは,ADおよびFTLDにおけるタウ病理とこの化合物の反応性を示した。また,生きたマウスタウオパシーモデルの光学的/PETイメージングのためにPM-PBB3を利用することができた。続く臨床PET研究は,疾患患者における18F-PM-PBB3の増加した結合を明らかにし,皮質優勢ADおよび皮質下優勢進行性核上性麻痺(PSP)タウトポロジーを反映した。特に,FTLDタウ封入体による18F-PM-PBB3のin vivo反応性は,PETスキャンを受けたPick病,PSPおよび皮質基底変性患者に由来する脳の神経病理学的検査により強く支持された。最後に,18F-PM-PBB3-PET画像の目視検査は,神経病理学的基礎上のFTLDの多様な臨床表現型の個別に基づく同定を容易にすることを示した。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 封入体 ,  *画像処理 ,  皮質 ,  放射化学 ,  側頭葉 ,  *Alzheimer病 ,  *病理 ,  PET【トモグラフィー】 ,  in vitro実験
準シソーラス用語： 進行性核上麻痺 ,  *タウオパチー ,  *バイオイメージング ,  前頭側頭葉変性症 ,  神経病理 ,  イメージングプローブ , 【Automatic Indexing@JST】

著者キーワード (10件)： タウオパシー ,  in vivoイメージング ,  PET ,  アルツハイマー病 ,  進行性核上性麻痺 ,  前頭側頭葉変性症 ,  ピック病 ,  皮質基底変性症 ,  タウオパシーマウスモデル ,  翻訳研究

分類 (1件)： 神経系の診断  (GN02000H)

タイトルに関連する用語 (5件)： アルツハイマー病 ,  Alzheimer病 ,  タウオパシー ,  病理 ,  イメージング