文献

J-GLOBAL ID：202202281310886584   整理番号：22A1070871

新規プロスタグランジンI2アゴニスト,ONO-1301は非アルコール性脂肪性肝炎モデルマウスにおける肝炎症を軽減し,線維症を抑制する

A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

著者 (13件)： Satoko Motegi, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Atsunori Tsuchiya, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Takahiro Iwasawa, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Takeki Sato, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Masaru Kumagai, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Kazuki Natsui, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Shunsuke Nojiri, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Masahiro Ogawa, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Suguru Takeuchi, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Yosiki Sakai, (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Shigeru Miyagawa, (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Yoshiki Sawa, (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Shuji Terai, (Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan)
資料名： Inflammation and Regeneration (Web)  (Inflammation and Regeneration (Web))
巻： 42  号： 1  ページ： 1-14  発行年： 2022年 
JST資料番号： U0220A  ISSN： 1880-8190  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： ONO-1301は,トロンボキサン(TX)A2シンターゼに対...

シソーラス用語： *肝炎 ,...
準シソーラス用語： *非アルコール性脂肪性肝炎 ,...

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著者キーワード (5件)： ONO-1301 ,  プロスタサイクリン ,  プロスタグランジンI_2 ,  プロスタグランジンE_2 ,  非アルコール性脂肪性肝炎

分類 (2件)： 消化器の基礎医学  (GH01020E) ,  消化器作用薬の基礎研究  (GW09010Q)

物質索引 (2件)： ONO-1301 ,  プロスタグランジンI2

引用文献 (36件)：

• Hepatology.; Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes; ZM Younossi, AB Koenig, D Abdelatif, Y Fazel, L Henry, M Wymer; 64; 1; 2016; 73-84; 10.1002/hep.28431; citation_id=CR1
• J Gastroenterol.; Comorbidities and healthcare costs and resource use of patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) in the Japan medical data vision database; S Terai, A Buchanan-Hughes, A Ng, IH Lee, K Hasegawa; 56; 3; 2021; 274-284; 10.1007/s00535-021-01759-2; citation_id=CR2
• J Gastroenterol.; Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study; Y Eguchi, H Hyogo, M Ono, T Mizuta, N Ono, K Fujimoto; 47; 5; 2012; 586-595; 10.1007/s00535-012-0533-z; citation_id=CR3
• Nat Rev Gastroenterol Hepatol.; Therapeutic pipeline in nonalcoholic steatohepatitis; R Vuppalanchi, M Noureddin, N Alkhouri, AJ Sanyal; 18; 6; 2021; 373-392; 10.1038/s41575-020-00408-y; citation_id=CR4
• Regen Ther.; Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles; T Watanabe, A Tsuchiya, S Takeuchi, S Nojiri, T Yoshida, M Ogawa, M Itoh, M Takamura, T Suganami, Y Ogawa, S Terai; 14; 2020; 252-261; 10.1016/j.reth.2020.03.012; citation_id=CR5

タイトルに関連する用語 (7件)： プロスタグランジンI2 ,  アゴニスト ,  ONO-1301 ,  非アルコール性脂肪性肝炎 ,  モデルマウス ,  肝炎症 ,  線維症