Rchr
J-GLOBAL ID:200901000430558291
Update date: Jul. 31, 2024
Nakabeppu Yusaku
ナカベップ ユウサク | Nakabeppu Yusaku
Affiliation and department:
Job title:
Director
Homepage URL (2):
http://www.bioreg.kyushu-u.ac.jp/nfg/index.html
,
https://www.bioreg.kyushu-u.ac.jp/nfg/english/index.html
Research field (11):
Molecular biology
, Environmental effects of chemicals
, Environmental effects of radiation
, Neuroscience - general
, Experimental pathology
, Tumor biology
, Pathobiochemistry
, Genetics
, Systems genomics
, Genomics
, Neuroanatomy and physiology
Research keywords (46):
8-オキソグアニン
, 酸化ストレス
, 自然突然変異
, 細胞死
, 突然変異
, 転写調節
, △FosB
, 2-OH-dATP
, Jun
, 8-oxodGTP
, 細胞周期
, 発がん
, ミトコンドリア
, FosB
, パーキンソン病
, p53
, OGG1
, アポトーシス
, 8-oxoguanine
, DNA複製
, 細胞複製
, CDK2
, Fos
, 酸化的DNA損傷
, 神経細胞死
, MTH1
, Comprehenseive Brain Science Network
, ヌクレオチドプール
, 幹細胞
, 遺伝子発現
, ストレス応答
, 神経新生
, 神経変性
, 発ガン
, DNA修復
, DNA損傷
, 活性酸素
, nucleotide pool
, Tissue Regeneration
, Gene expression
, Stress response
, Neurodegeneration
, Carcinogenesis
, DNA repair
, DNA damage
, Reactive Oxygen Species
Research theme for competitive and other funds (74):
- 2021 - 2024 Shank3欠損マウスと患児オルガノイドを用いた視床・感覚路発達メカニズムの解析
- 2019 - 2022 A study for convergent molecular mechanisms underlying epileptic encephalopathy using cortical organoids
- 2017 - 2020 活性酸素による脳機能障害とその防御機構の解明
- 2015 - 2018 Development of a new translational medicine for epilepsy using the Pten-mutant mice
- 2015 - 2017 慢性腎不全が誘発する脳機能障害における核酸の酸化損傷とその防御機構の関与の解明
- 2014 - 2017 Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguanine
- 2014 - 2017 Function of histone methyltransferase PR-set7 and its relationship to carcinogenesis
- 2013 - 2016 hTFAM improves impaired insulin signaling in Alzheimer's disease
- 2011 - 2015 Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse
- 2010 - 2014 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明
- 2013 - 2014 Galectin-1による筋萎縮性側索硬化症の発症と進行の二面的制御
- 2011 - 2013 Analysis of chromatin function mediated by histone H4 lysine 20 methylation
- 2011 - 2013 Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout Mice
- 2011 - 2012 Regulatory mechanisms of brain function by alternative splicing products of fosB gene
- 2010 - 2012 Development of apomorphine therapy for Alzheimer disease
- 2010 - 2012 Regulation of MUTYH expression by p53 plays a critical role in cell death
- 2008 - 2009 Genomic damage and cancer cell death caused by reactive oxygen species
- 2007 - 2009 Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation
- 2007 - 2009 Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models
- 2006 - 2007 酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働き
- 2006 - 2007 Roles of the defense mechanisms against oxidative damage in nucleic acids for maintenance of brain cells
- 2004 - 2006 Molecular pathological analysis of defects in DNA base excision repair system using gene modified mice
- 2005 - 2005 酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働き
- 2004 - 2004 ゲノム多型及び遺伝病の成因としての自然DNA酸化損傷とその修復機構の破綻
- 2003 - 2004 The sanitizing systems for endogenous nucleotide lesions, and their roles on spontaneous mutagenesis
- 2002 - 2004 Establishment of detectional system of individual tumor markers
- 2002 - 2004 Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
- 2000 - 2004 Oxidative DNA damage-induced tumorigenesis and its avoidance mechanism
- 2003 - 2003 ヒト癌におけるMTH1発現亢進の意義の解明とMTH1の発現・機能抑制法の開発
- 2001 - 2002 Implication of oxidized nucleotides in spontaneous mutation and their sanitizing systems
- 2001 - 2002 Study on oxidative DNA damage and repair enzyme in acute and chronic renal disease
- 1999 - 2001 Study of Defense Mechanisms against Cellular Damage Caused by Free Radicals
- 1999 - 2000 The total analyses of the mechanism of the invasion and metastasis in human oral squamus cell carcinoma by the transcriptional factors
- 1999 - 2000 Analysis of the regulated mechanisms of cell proliferation and apoptosis in the endometrium at AP-1 binding site
- 1999 - 2000 アルツハイマー病の細胞内Aβ42誘導性ニューロンアポトーシス死の分子メカニズム
- 1998 - 2000 Oxygen-induced DNA damage and its repair mechamism
- 1998 - 2000 DNA Repair Mechanisms Protecting Brain and Neuronal Cells from Damage Caused by Reactive Oxygen Species
- 1998 - 1998 プロトオンコジーンfosBによる細胞増殖と細胞死の制御機構の解析
- 1998 - 1998 活性酸素による神経細胞死とその防御機構の解析
- 1997 - 1997 Repair of alkylation DNA damage
- 1997 - 1997 ヒト発がんにおける複製・修復遺伝子の変異
- 1997 - 1997 ヒトMTH1蛋白質の発現制御と突然変異抑制機能の解析
- 1997 - 1997 活性酸素による神経細胞死とその防止機構の解析
- 1996 - 1997 Development of an Effecient System for Gene Targeting
- 1997 - 活性酸素によるゲノム障害とその防御機構の解明
- 1997 - Studies on Mechanisms Protecting Genomic Integrity from Damage Caused by Reactive Oxygen Species.
- 1996 - 1996 転写制御遺伝子群の発癌への関与
- 1996 - 1996 哺乳動物における酸素ラジカルによる自然突然変異とその抑制機構
- 1995 - 1995 転写制御遺伝子群の発癌への関与
- 1995 - 1995 Active Oxygen-induced DNA Damage and its Repair Mechanisms
- 1993 - 1995 Molecular Mechanisms of Differentiation and Proliferation Switches
- 1994 - 1994 転写制御遺伝子群の発癌への関与
- 1994 - 1994 Oxygen-induced DNA Damage and its Repair Mechanisms
- 1994 - 1994 ΔFosBによる細胞複製の制御
- 1994 - 1994 fosB遺伝子による細胞のがん化と遺伝子発現制御
- 1993 - 1993 △FosBによる細胞の癌化と遺伝子発現
- 1993 - 1993 Fos,Junによる細胞複製の制御
- 1993 - 1993 FosBおよび△FosBによる細胞分化の制御
- 1991 - 1993 O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割
- 1991 - 1993 Information Exchange on Cancer Research with North American Countries.
- 1992 - 1992 Fos,Junの標的遺伝子の検索
- 1992 - 1992 Fos,Junによる細胞複製の制御
- 1991 - 1992 O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割
- 1990 - 1992 Molecular mechanisms of the adaptive response to alkylating agents
- 1991 - 1991 O^6ーアルキルグアニンーアルキル転移酵素の制がんと発がんにおける役割
- 1991 - 1991 Jun/Fos複合体(APー1)による細胞複製の制御
- 1986 - 1990 Maintenance of Genetic Information and Mutagenesis Mechanisms
- 幹細胞の維持機構
- 発癌モデルマウスの作製
- 神経変性疾患モデルマウス作製
- 微量修飾核酸の検出法の開発
- Generation of mouse model for tumorigenesis
- Generation of mouse model for neurodegenerative disorders
- Development of detection methods for minor modified nucleic Acids
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Papers (335):
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Mizuki Ohno, Noriko Takano, Kyoko Hidaka, Fumiko Sasaki, Kazumi Yamauchi, Yasunobu Aoki, Takehiko Nohmi, Yusaku Nakabeppu, Yoshimichi Nakastu, Teruhisa Tsuzuki. Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice. Genome research. 2024
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Carol E Schrader, Travis Williams, Klaus Pechhold, Erin K Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu. APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. Journal of immunology (Baltimore, Md. : 1950). 2023. 210. 11. 1804-1814
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Teruya Nakamura, Yukari Koga-Ogawa, Kana Fujimiya, Mami Chirifu, Masataka Goto, Shinji Ikemizu, Yusaku Nakabeppu, Yuriko Yamagata. Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. FEBS Letters. 2023
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Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Takashi Saito, Takaomi C. Saido, Ryo Yamasaki, Jun-ichi Kira, Yusaku Nakabeppu. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior. Neuroscience Research. 2022. 177. 118-134
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Kazuya Matsuo, Yasuharu Shinoda, Nona Abolhassani, Yusaku Nakabeppu, Kohji Fukunaga. Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin. Frontiers in Psychiatry. 2022. 13
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MISC (90):
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中別府 雄作. アルツハイマー病を脳の糖尿病として捉える. 2020
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Murakami, Y., Nakabeppu, Y., Sonoda, K. Oxidative Stress and Microglial Response in Retinitis Pigmentosa. International Journal of Molecular Sciences. 2020. 21. 19. 1-16
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酒井 康成, 赤峰 晢, 奥園 清香, 瀬戸山 大樹, 山元 裕之, 康 東天, 中別府 雄作, 大賀 正一. てんかん性脳症に関与する収束的分子シグナルの解明. 2018
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春山 直樹, 作見 邦彦, 加藤木 敦央, 土本 大介, 中別府 雄作. 側坐核・カレハ島の新生GABAニューロンへの8-オキソグアニンの蓄積は加齢マウスの多動の原因となる. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-1251]
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作見 邦彦, 大野 みずき, 中別府 雄作. 遺伝性疾患自然発症モデル動物としてのmutator mouse. 生命科学系学会合同年次大会. 2017. 2017年度. [2PT26-09(3P
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Patents (2):
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酸化プリンヌクレオシド三リン酸分解酵素阻害剤のスクリーニング方法
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老化促進および免疫不全症のモデル動物
Books (8):
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DNA Replication and Transcription, in: M. RA (Ed.), Genomics and Genetics: From Molecular Details to Analysis and Techniques.,pp. 47-73.
Wiley-VCH Verlag GmbH & Co., Weinheim, Germany 2007
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Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides. in Oxidative Damage to Nucleic Acids (ed. M.D. Evans and M.S. Cooke). pp. 40-53.
Landes Bioscience / Springer, Georgetown, TX. / New York, NY. 2007
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遺伝子変異の機構
図説 分子病態学 第3版(中外医学社) 2003
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アポトーシスを抑制して病気の進展を予防することは可能か?
アポトーシスと疾患-中枢神経疾患編-(医薬ジャーナル社) 2000
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転写因子としてとらえる癌遺伝子・癌抑制遺伝子
転写のメカニズムと疾患(羊土社) 1997
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Lectures and oral presentations (73):
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アルツハイマー病とその危険因子:糖尿病、酸化ストレス、性差
(第一回レドックスR&D戦略委員会公開シンポジウム -レドックスホメオスタシスと認知症・生活習慣病- 2021)
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High-fat diet aggravates the hippocampal Alzheimer disease pathology in the AppNL-F/NL-F mouse model
(SfN Global Connectome 2021)
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活性分子種による核酸の化学修飾に起因する病態とその防御機構
(日本遺伝学会 第92回大会 2020)
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Defense mechanisms against the dysfunction resulting from damage to the genome by reactive oxygen species during aging
(The 2019 International Association of Gerontology and Geriatrics (IAGG) Conference 2019)
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8-Oxoguanine accumulation in aged female brain impairs neurogenesis in dentate gyrus and major island of Calleja, and thus causing sexually dimorphic phenotypes
(The 42nd Annual Meeting of The Japan Neuroscience Society 2019)
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Education (3):
- 1981 - 1984 九州大学 大学院 理学研究科 博士課程 生物学専攻 (分子遺伝学)
- 1979 - 1981 九州大学大学院 理学研究科 修士課程 生物学専攻(分子遺伝学)
- 1975 - 1979 University of Miyazaki Faculty of Agriculture Department of Veterinary Sciences
Professional career (1):
- D. Sci (Doctor of Science) (Kyushu University)
Work history (6):
- 2022/04 - 現在 Japan Society for the Promotion of Science (JSPS) San Francisco Office Director
- 2010/10 - 2022/03 Kyushu University Distinguished Professor
- 2001/04 - 2022/03 Kyushu University Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation Professor
- 2016/04 - 2020/03 Kyushu University Medical Institute of Bioregulation
- 2011/04 - 2015/03 Research Center for Nucleotide Pool Director
- 1997/08 - 2001/03 Kyushu University Department of Biochemistry, Medical Institute of Bioregulation Professor
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Awards (3):
- 2018/09 - The Genetic Society of Japan Kihara Prize Defense mechanisms against the dysfunction resulting from damage to the genome by reactive oxygen species
- 2006/09 - 昭和シェル石油環境研究助成財団 第2回昭和シェル石油環境研究成果賞 活性酸素によるDNA障害とその修復機構に関する解析
- 1994/09 - 日本癌学会 奨励賞 プロトオンコジーンfos, junによる細胞増殖の制御
Association Membership(s) (11):
THE JAPAN NEUROSCIENCE SOCIETY
, Society for Redox Biology and Medicine
, 日本遺伝学会
, 日本がん疫学・分子疫学研究会
, ミトコンドリア学会
, 日本癌学会
, 日本生化学会
, 日本分子生物学会
, Society for Neuroscience
, American Society for Microbiology
, American Society for Biochemistry and Molecular Biology
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