Araki Kimi

2019 - 2023 Study on epigenetic changes of the genes involved in the malformations of the fetus affected by diabetes

2019 - 2022 Itpr1-deficient mice show reduced viability and birth rate with bone loss.

2019 - 2022 Elucidation of epigenomic regulation by chromosome segregation factor and identification of novel therapeutic target for leukemia

2018 - 2022 Production of humanized mouse models for chronic recurrent multifocal osteomyelitis and antiinflammatory drug development

2018 - 2021 Comprehensive functional analyses of novel genes involved in bone and cartilage metabolism

2017 - 2020 Analysis of Tmem161a function in bone metabolism using the exchangeable gene trap mutagenesis

2017 - 2019 Analysis of spontaneous polycythemia model mouse "pocy" showing recessive inheritance.

2014 - 2017 The detrimental effect of soluble IL-6 receptor on CD4 T cell-mediated anti-tumor immune responses

2013 - 2016 Establishment of chimeric mice having a primatized intervertebral discs and comprehensive research of the primatized intervertebral disc.

2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

2012 - 2015 Generation and analysis of chronic pancreatitis model mice

2012 - 2015 Development of innovative treatments for epilepsy based upon its molecular pathomechanisms using patient iPS cells and novel genetically engineered animals.

2011 - 2014 Establishment of Cre-driver mouse lines by using the Exchangeable Gene Trap Ckones.

2009 - 2014 Genetic studies on unique phenotypes in MSM/Ms mouse strain

2011 - 2013 Construction of a model mouse library related to osteogenic and chondrogenic disease using an exchangeable gene trap mutagenesis

2011 - 2012 Analysis of genome inactivation mechanism using chromosomal site-specific gene integration

2010 - 2012 Elucidation for molecular etiology of Danforth's short tail (Sd)mutant, a caudal regression model mouse

2010 - 2012 Establish of mutant S19 ribosomal protein dimer functional deficient mice

2009 - 2011 Development of genetically engineered animal models and novel therapeutic measures for human Epilepsy

2008 - 2010 Expression Analysis of the Exchangeable Gene Trap Clones by X-gal Staining

2005 - 2009 Integrated cancer research using in vivo models

2007 - 2008 Establishment of ES cell lines derived from MSM/Ms and JF1/Ms lines and production of genetically engineered mice

2006 - 2008 Establishment of animal model harboring a homologous mutation ofhuman epilepsy and analysis of genomics"

2006 - 2008 Genetic analyses and generation of genetic engineered animals for childhood epilepsy focusing on ion channel abnormalities

2004 - 2008 Analysis of molecular biology of epilepsy

2005 - 2005 可変型遺伝子トラップクローンデータベース;EGTC

2004 - 2005 コートカラーではgerm lineに伝わるが導入遺伝子は伝わらないキメラの解析

2003 - 2005 Regulation of apoptosis by chemotactic human ribosomal protein S19 mutant protein.

2003 - 2005 Generation and neuro-pharmacological analysis of epilepsy model animals bearing mutations identified in human epilepsy II

2003 - 2004 Functional compatibility of Rho family genes in vivo.

2001 - 2004 Isolation and functional analysis of genes related to delayed neuronal death in mouse hippocampus

2001 - 2003 Develpment of a new method to revent amyloid formation in genetically engineered mice.

2000 - 2001 Attempts to integrate a transgene into a specific locus in the mouse genome by microinjection to fertilized eggs

2000 - 2000 可変型遺伝子トラップによる挿入突然変異マウス作製とそのカタログ化

1999 - 2000 可変型遺伝子トラップにより得られた挿入突然変異マウスの解析と応用

1999 - 2000 IDENTIFICATION OF DISEASE GENE USING BAC TRANSGENIC MICE

1999 - 1999 可変型遺伝子トラップによる挿入突然変異マウス作製とそのカタログ化

1998 - 1999 DEVELOPMENT OF PREVENTION METHOD USING A MOUSE MODEL FOR FAMILIAL AMYLOIDOTIC POLYNEUROPATHY

1997 - 1999 Attempt on targeted integration of DNA in transgenic mice system

1997 - 1998 Cre-loxシステムを応用した遺伝子トラップによる発生関連遺伝子の単離と解析

1995 - 1996 MOLECULAR MECAHNISMS OF ENDODERM DIFFERENTIATION

1995 - 1995 Cre-loxPシステムを用いた新しい遺伝子トラップベクターの開発

1992 - 1994 PRODUCTION OF MOUSE MODELS FOR MALFORMATION BY GENE TRAP

1992 - 1994 Production of mouse models for human diseases by gene targeting