Kodama Tetsuya | Researcher Information

Tohoku University Grad School Eng, Grad School Med, Inst Fluid Sci, Grad School Dent

2023 - 2026 Multimodal cancer therapy and diagnostic system using 256-channel diamond quantum sensor array
2023 - 2026 Research on optimization of low-intensity ultrasonic irradiation conditions for ultrasonic therapy to activate self-healing power
2021 - 2025 Novel Rat Model and Intervention for Elucidating the Molecular Mechanism in Chronic Postsurgical Pain
2021 - 2024 Development of innovative lymphatic drug delivery system for distant metastasis treatment
2020 - 2023 Development of a lymphatic drug delivery system for local control of metastatic lymph nodes to systemic metastatic therapy

2019 - 2022 Super-early stage diagnosis of the metastatic lymph nodes using the measurement of intra-lymph node pressure and lymphatic drug delivery system

2019 - 2022 Development of multi-scale ultrasound pathological diagnosis method reflecting physical characteristics of living tissue

2019 - 2021 An experimental study on the theory of lymph node-mediated hematogenous metastasis

2018 - 2021 Comprehensive study on precise diagnosis and new chemotherapy for micrometastatic lymph nodes

2017 - 2020 Therapeutic system for metastatic lymph nodes at early stages

2017 - 2020 Low operation by siRNA with angiogenetic inductive action and modal nano drug delivery, initiation of hurt repairing procedure

2016 - 2020 Early diagnosis and low invasive treatment of cancer by micro/nano thermal engineering

2017 - 2019 Development of a new radiotherapy using targeted nanobubbles and ultrasound for metastatic lymph nodes

2017 - 2019 Innovative theranostics system with magnetic carbon nanotube

2017 - 2019 gene delivery into lymphocytes using lymphatic administration and ultrasound

2016 - 2019 Identification of microRNAs associated with distant metastasis in model mouse

2017 - 2019 Development of a minimally invasive treatment method using biocompatitive gold nanorods and near-infrared laser light for lymph node metastasis

2016 - 2018 Treatment for lymph node metastasis of oral cancer by using lymphatic administration of anticancer agent-encapsulated liposomes

2015 - 2018 High-frequency ultrasound diagnostic imaging system to detect niche formation in the lymph nodes in a pre-metastatic phase

2016 - 2018 リンパ節転移モデルを用いた転移リンパ節の治療法に関する研究

2014 - 2017 Development of a novel agent for ultrasound which can show engarftment of transplanted islets and eraly discovery of neuroendocrinal tumor.

2014 - 2017 Development of early diagnosis and treatment for lymph node metastasis

2014 - 2017 Establishment of novel non-invasive therapy for siRNA-induced vasculogenesis using sonoporation techniques, nano-size drug delivery systems

2014 - 2017 Quantification of breast cancer microenvironment by three dimensional integration of micro bubble contrast ultrasound and MRI image

2013 - 2017 Development of volume registration method for diagnosis of metastatic lymph node of head and neck cancer by ultrasound imaging

2015 - 2017 頭頸部リンパ節転移モデルマウスを用いた薬剤内封ミセルの動態と効果に関する研究

2013 - 2016 Diagnostic system using a high-frequency ultrasound with contrast agent to distinguish cancerous area from keratotic lesion of oral mucosa

2013 - 2016 Drug delivery system using nano-microbubbles and ultrasound applicable to a gene therapy for temporomandibular joint ankylosis

2012 - 2016 高精度超音波画像診断装置の開発

2012 - 2015 Development of alveolar bone regenerative therapy using nano/microbubbles with IGF-I plasmid gene.

2012 - 2015 Three dimensional structural analysis and functional evaluation of lymphatic network

2012 - 2015 Development of real-time image analysis system of cervical lymph node network using nanobubbles

2012 - 2014 Development of a Vasohibin gene delivery system using nano/microbubbles and ultrasound

2012 - 2014 Development of contrast agent of ultrasonography for visualizing pancreatic islets

2012 - 2014 Experimental study towards the development of lymphatic drug delivery system for the treatment of cervical lymph node metastasis

2011 - 2014 Super-selective molecular delivery system of metastatic lymph node using nanobubbles and ultrasound

2011 - 2013 Development of the novel approaches to diagnose and treat head and neck cancer using nanotechnology

2008 - 2013 流動ダイナミックス知の融合教育研究世界拠点

2011 - 2012 Exploration of Optimum Conditions for Sonoporation Effect by Controlling Multi-Phase Flow Field with Microscopic Visualization

2011 - 2012 超音波診断・治療技術に関する研究

2010 - 2012 Development of imaging diagnosis system for oral cancer utilizing lesion-integrated nanobubbles and high frequency ultrasound

2010 - 2012 Molecular delivery therapy for metastatic liver tumor derived from pancreatic cancer using the nanobubble

2009 - 2012 An experimental study for developments of a 4D-imaging system and a novel gene therapy for the hemangioma using nanobubbles and ultrasound

2006 - 2012 超音波計測練成解析による超高精度生体機能計測システム

2010 - 2011 Development of a Simulation Technique for Gene/Cancer Therapy Using Nano/Micro Bubbles

2010 - 2011 Development of the cure by the transgenics using the nano bubble to the Recklinghausen disease

2010 - 2011 Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes

2010 - 2011 超音波診断・治療技術に関する研究

2009 - 2011 An experimental study for development of real time diagnosis system for oral cancer treatment using nanobubbles and ultrasound

2009 - 2011 Development of a real time diagnosis of lymph node metastasis by ultrasound and nanobubbles

2009 - 2011 An experimental study for a novel gene therapy for the highly malignant tumor of salivary gland using nanobubbles and ultrasound

2009 - 2010 ナノバブルと超音波を用いた転移性肝がんに対する新たな遺伝子治療法の開発

2009 - 2010 東北大学医工学研究科研究科長裁量経費

2009 - 2010 ナノバブルを用いた転移リンパ節遺伝子治療法の開発

2009 - 2010 長期安定性ナノバブルの開発とがん治療への応用

2008 - 2010 Development of gene therapy of liver and bladder cancer by using nanobubbles and ultrasound

2008 - 2010 Transfection of Kir6. 2 channel genes into native vascular smooth muscle using sonoporation

2008 - 2010 Focused Ultrasound Controlled Cavitation Bubble Collapse and Promotion of Sonoporation Effect

2007 - 2010 ナノバブルと超音波を用いたワクチン療法の開発と若手研究者育成事業

2007 - 2010 ナノバブルと超音波を用いた高周波超音波三次元画像診断・分子導入システムの開発

2006 - 2010 In vivo イメージング技術の開発と生体運動機構の解明.

2008 - 2009 ナノバブルを用いた腫瘍新生血管標的性リアルタイム超音波分子導入システムの開発

2008 - 2009 東北大学研究科長裁量経費

2008 - 2009 非侵襲組織標的性分子導入法を用いたがん確定診断法の開発

2007 - 2009 Evaluation of Angiogenesis by High Resolution Three-dimensional Ultrasound Molecular Imaging

2007 - 2009 An imaging and drug delivary system for treatment of oral cancer by using ultrasound and nano-bubbles

2007 - 2009 臓血管系の計測融合数理モデルとレーザー計測

2007 - 2008 A feasibility study for the treatment of oral cancer using a new drug delivery system and cell inhibitor

2007 - 2008 ナノバブルによる新しい遺伝子導入法の開発と末梢循環障害の治療への応用

2007 - 2008 A feasibility study for a new vaccination system using Nanobubbles and ultrasound

2005 - 2008 超音波を利用したsiRNA内包バブルリポゾームのがん局所療法の臨床試験導入

2006 - 2007 ナノバブルによる新しい遺伝子導入法の開発とがん治療への応用

2006 - 2007 ナノバブルを用いたリアルタイム分子導入法の開発と腫瘍血管新生抑制治療への応用

2006 - 2007 非侵襲的脊髄遺伝子導入による新たな疼痛治療戦略の開発

2005 - 2007 Development of a high-throughput molecular delivery method using microbubbles and ultrasound and its application to cancer gene therapy

2005 - 2007 ナノバブルによる血中ドラッグデリバリーを利用する新しい癌治療技術の研究

2005 - 2006 Experimental study for development of microbubble applicable to clinical use in oral cancer chemotherapy

2005 - 2006 口腔癌病巣集積型マイクロバブルの開発と治療への応用

2005 - 2006 次世代型・高次超音波・分子導入装置の開発

2005 - 2005 マイクロ気泡による新しい分子導入法の開発とがん画像診断への応用

2002 - 2003 Inhibition of intracoronary stent-Induced intimal hyperplasia with targeted microbubbles carrying the E2F decoy

1998 - 1999 衝撃波伝播にともなう機能的形態的細胞損傷機構に関する研究

1997 - 1998 An Experimental Study of Photdynamic Therapy and Sonodynamic Therapy for Obstructive Cerebrovascular Diseases

1997 - 1998 超微小火薬の医療応用に関する基礎研究

1995 - 1996 Basic Study of sound-dynamic Therapy for Atherosclerotic Cerebrovascular Disease.

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Akiyoshi Obonai, Takuma Kogawa, Yuki Kanda, Tetsuya Kodama, Atsuki Komiya. Modeling of scattering coefficient for biological tissues exposed to near-infrared laser irradiation. Applied Thermal Engineering. 2024. 256. 123990-123990
Takagi K, Sukhbaatar A, Mori S, Kodama T. A combination of lymphatic drug delivery of anti-CTLA-4 antibody and local radiotherapy for solid-tumor treatment. Cancer Science. 2024
Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Krasimir Vasilev, Rodney Maluleke, Ncediwe Tsolekile, Olanrewaju A. Aladesuyi, et al. Facile green synthesis of dual stabilized near-infrared CuInSe/ZnS quantum dots as fluorescent probes for cancer-bacteria imaging. Inorganic Chemistry Communications. 2024. 167. 112795-112795
Gracia It Mwad Mbaz, Thabang Calvin Lebepe, Rodney Maluleke, Akiyoshi Obonai, Nande Mgedle, Olanrewaju A. Aladesuyi, Rajendran Kalimutu, Tetsuya Kodama, Atsuki Komiya, Oluwatobi Samuel Oluwafemi. Photothermal Depth Profiling of Gelatin-Stabilised Gold Nanorods-Trastuzumab Conjugate as a Potential Breast Cancer Photothermal Agent. Journal of Inorganic and Organometallic Polymers and Materials. 2024
Ariunbuyan Sukhbaatar, Shiro Mori, Tsuyoshi Sugiura, Tetsuya Kodama. Docetaxel administered through a novel lymphatic drug delivery system (LDDS) improved treatment outcomes for lymph node metastasis. Biomedicine & Pharmacotherapy. 2024. 171. 116085-116085

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スフバートルアリウンブヤン, スフバートルアリウンブヤン, 宮下仁, 森士朗, 森士朗, 森士朗, 小玉哲也, 小玉哲也, 小玉哲也, 小玉哲也. 腫瘍増殖状態が異なる転移リンパ節に対するLDDSの治療効果. 日本癌学会学術総会抄録集(Web). 2021. 80th
栗生晏暉, スフバートルアリウンブヤン, 森士朗, 小玉哲也. X線照射後のICGリポソームリンパ行性送達能の評価. 日本癌学会学術総会抄録集(Web). 2021. 80th
空翔太, スフバートルアリウンブヤン, 森士朗, 小玉哲也. 肺転移およびリンパ節内腫瘍に対する全身照射の効果. 日本癌学会学術総会抄録集(Web). 2021. 80th
KODAMA Tetsuya. Lymph nodes targeted in novel cancer therapy. Research Outreach. 2018. 105. 22-25
Horie S, Kodama T, Sato Y. Application of a drug delivery system using ultrasound and nano/microbubbles for anti-angiogenic therapy. Radiation Biology Research Communications. 2017. 52. 1. 14-23

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Methods Molecular Biology
Sung-Bae Kim (Eds): Bioluminescence 2022 ISBN:9781071624524
Medical Practice 39巻4号〈リンパ節腫大の診療〉
文光堂 2022
Recent technology of microbubbles vol.2
NTS 2014 ISBN:9784860434076

Pharmacokinetic Analysis in Lymphatic Drug Delivery System
(21st International Conference on Flow Dynamics)
Treatment of Metastatic Lymph Node by Lymphatic Drug Delivery System Using Carboplatin
(21st International Conference on Flow Dynamics)
Evaluation of Chemoimmunotherapy using Lymphatic Drug Delivery System
(21st International Conference on Flow Dynamics)
High-frequency Ultrasound Imaging Analysis of Intravascular Flow Dynamics in Metastatic Lymph Nodes
(21st International Conference on Flow Dynamics)
Evaluation of a minimally invasive prototype fiber optic probe for breast cancer treatment.
(The 34th International Symposium on Transport Phenomena)

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Ph.D.(Medicine) (Tohoku University)
PhD(Engineering) (Tohoku University)

2008 - Tohoku University Graduate School of Biomedical Engineering 教授
2004 - Tohoku University Biomedical Engineering Research Organization 助教授
2002 - Imperial College London Faculty of Medicine Reseacrh Associate
2000 - Department of Medicine, Harvard Medical School Brigham and Women's Hospital Research Associate
1998 - Department of Dermatology, Harvard Medical School Massachusetts General Hospital Instructor

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2022/07 - 現在 Science Advances reviewer
2018/09 - 現在 Nature Reviews Materials 学術雑誌校閲員
2015/04 - 現在 Scientific Reports 校閲委員
2014/10 - 現在日本超音波医学会工学フェロー
2014/08 - 現在日本DDS学会評議員

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2024/09 - 日本超音波医学会第68回東北地方会学術集会奨励賞超音波RF信号を用いたクラッタフィルタ再構成による転移リンパ節の血管抽出
2024/07 - 第78回NPO法人日本口腔科学会学術集会 Rising Scientist賞抗 CTLA4 抗体を用いたリンパ行性薬物送達法によるがん免疫療法に関する実験病理学的検討
2024/07 - Journal Award Lymphatic Drug Delivery System of Single Dose Anti-CTLA4 Enhance by Local X-Ray Irradiation Treatment for Lymph Node Metastatic
2023/12 - 日本生体医工学会関東支部優秀論文発表賞転移リンパ節に対する磁性ナノ粒子Resovist® を用いた磁気温熱療法の開発
2022/06 - Oustanding Student Presentation

2022/01 - Japan Society of Mechanical Engineers Oustanding Student Presentation

2020/09 - The 60th Annual Meeting of The Japan Society of Ultrasonics in Medicine Encouragement Prize A study on the evaluation of treatment efficacy of metastatic lymph nodes associated with changes in drug osmotic pressure in the lymphatic drug delivery system

2017/08/03 - 3rd Annual Data Science in Life Science and Engineering Collaboration and Symposium Oral Presentation 1st Place New insights on Lymph node metastasis : the benefit of using our mouse model in cancer metastasis

2017/04/13 - 第76回日本医学放射線学会総会 CyPos賞 Silver medal Quantitative analysis of contrast-enhanced ultrasound for diagnosis of early lymph node metastasis of breast cancer.

2016/10/01 - 第67回仙萩会総会学術奨励賞 Direct Delivery of a Cytotoxic Anticancer Agent into the Metastatic Lymph Node Using Nano/Microbubbles and Ultrasound.

2016/05/28 - 日本超音波医学会第5回新人賞ソノポレーションを利用したVasohibin-1 遺伝子導入による抗腫瘍効果の評価

2016/05/28 - 日本超音波医学会第89回学術集会第17回奨励賞乳癌における造影超音波を用いた血管密度定量法

2014/03/13 - The 8th East Asian Consortium on Biomedecal Engineering Oral Presenation Award Study of diagnosis of lymph node metastasis by Micro-CT

2014/03/13 - 第76回情報処理学会全国大会学生奨励賞超音波画像診断における微小気泡造影剤の検出手法の検討

2014/03/12 - 8th Student Workshop East Asia Consortium on Biomedical Engineering The Presentation Award Inhibition of tumor growth in lymph nodes by lymphatic administration od frugs and nano/microbubbles with ultrasound exposure.

2013/11/09 - 第27回日本泌尿器内視鏡学会総会 Young Endourologist Award(ポスター部門) リンパ節担がんマウスに対する超音波と微小気泡をもちいた抗がん剤治療に関する研究

2013/10/01 - 第58回日本口腔外科学科総会・学術大会優秀講演発表賞ナノバブルと高周波超音波による微小リンパ節転移画像診断法の検討

2013/03/24 - The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering Oral Presenation Award Early diagnosis of lymph node metastasis by micro-CT.

2013/03/23 - The 7th East East Asian Consortium on Biomedecal Engineering Oral Presenation Award Development of a method for doxorubicin delivery through lymphatic vessel into a metastatic lymph node using nano/micro bubbles and ultrasound

2011/03/16 - IADR/AADR IADR/AADR William J. Gies Award Periodontal gene transfer by ultrasound and nano-/microbubbles

2009/07/07 - 第25回日本DDS学会第25回日本DDS学会ベストポスター賞 124I を使用したNIS遺伝子発現イメージング法の開発:超音波とナノバブルを利用した遺伝子デリバリー

2008/10/30 - 日本癌治療学会第46回日本癌治療学会総会優秀演題賞高周波超音波イメージングシステムを用いた所属リンパ節転移画像診断システムの開発

2008/10/20 - 第53回日本口腔外科学会総会ゴールドリボン賞ナノバブルと超音波を用いた腫瘍血管造影法による口腔癌診断システムモデルの開発

2008/10/20 - 第53回日本口腔外科学会総会ゴールドリボン賞ナノバブルと超音波を用いた抗癌剤および抗腫瘍分子導入による新たな癌治療法の開発

2008/06/30 - 日本実験力学会日本実験力学会2008年度年次講演会優秀講演賞受賞歯周組織への遺伝子導入を目指した新しい非ウイルス法の開発

2007/05 - 日本超音波医学会日本超音波医学会第8回奨励賞ソノポレーションによる遺伝子導入効率:気泡特性に対する検討

2006/06/01 - The 11th Congress of the world federation for ultrasound in Medicine and Biology. Paper Presenter Award Delivery of sodium/iodide symportter therapy using nanobubbles with ultrasound.

2006/06/01 - The 11th Congress of the world federation for ultrasound in Medicine and Biology. WFUM’B 2006 Paper Presenter Award HSV-tk/GCV Cytotoxic Gene Therapy using ultrasound and nanobubbles

2006/06/01 - The 11th Congress of the world federation for ultrasound in Medicine and Biology. WFUM’B 2006 Paper Presenter Award Effects of anti-cancer drug of cisplatin using nanobubbles and ultrasound

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The Japanese Society of Lymphology , Japanese Society of Oral and Maxillofacial Surgeons , Japan Society of Drug Delivery System , Japanese Cancer Association , Japan Society of Ultrasonics in Medicine , Japan Society of Mechanical Engineers , 日本生体医工学会 , 日本口腔外科学会 , Biophysical Society