Yasui Manabu

Affiliation and department：
Job title： Researcher
Homepage URL (1)： http://www.nihs.go.jp/dgm/index.html

Research field (2)： Environmental effects of chemicals , Environmental effects of radiation

Research keywords (8)： Gene mutation , 環境リスク , 化学発がん , 環境変異原 , 突然変異 , Chemical carcinogenesis , DNA adduct , Mutagenesis

Research theme for competitive and other funds (13)：

2021 - 2024 透析膜を利用した新しい代謝活性化システムによるDNA付加体の形成と同定
2019 - 2022 Quantum chemical challenge to elucidate the functional mechanism of base sequence specificity deciding removal of the DNA damage
2016 - 2021 Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
2013 - 2019 Construction of a DNA double-strand break model and its application to studies of DNA repair and low dose irradiation effects
2013 - 2019 Site-specific gene mutagenesis involving a single DNA adduct in vivo

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Papers (41)：

Weiying Liu, Manabu Yasui, Akira Sassa, Xinyue You, Jingjing Wan, Yiyi Cao, Jing Xi, Xinyu Zhang, Masamitsu Honma, Yang Luan. FTO regulates the DNA damage response via effects on cell-cycle progression. Mutation research. Genetic toxicology and environmental mutagenesis. 2023. 887. 503608-503608
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura. In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde. Genes and Environment. 2021. 43. 1
Akira Sassa, Takayuki Fukuda, Akiko Ukai, Maki Nakamura, Ryosuke Sato, Sho Fujiwara, Kouji Hirota, Shunichi Takeda, Kei-Ichi Sugiyama, Masamitsu Honma, et al. Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells. Mutagenesis. 2021
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-Ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma. Development of a new quantitative structure-activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDropTM auto-ModellerTM. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021. 43. 1. 16-16
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, et al. Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021. 43. 1. 7-7

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MISC (40)：

小田切瑞基, 安井学, 本間正充, 杉山圭一, 浦聖恵, 佐々彰. Establishment of an epigenotoxicity assay using the human lymphoblastoid TK6 cell line. 日本環境変異原ゲノム学会大会プログラム・要旨集. 2021. 50th
竹石歩奈, 古樫浩之, 小田切瑞基, 笹沼博之, 武田俊一, 安井学, 本間正充, 菅澤薫, 浦聖恵, 佐々彰. Tyrosyl-DNA phosphodiesterasesはDNA中のリボヌクレオチドを起因とする突然変異形成に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
小林春花, 東條あかり, 佐々彰, 安井学, 本間正充, 浦聖恵. 転写活性領域におけるDNA二本鎖切断修復経路の選択に果たすヒストンメチル化酵素NSD2の役割. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
小田切瑞基, 安井学, 本田大士, 浦聖恵, 佐々彰. Development of the ”epi-TK assay” for quantitative evaluation of chemical-induced epigenetic changes using human lymphoblastoid TK6 cells. 日本環境変異原学会大会プログラム・要旨集. 2020. 49th (CD-ROM)
佐々彰, 安井学, 竹石歩奈, 原田佳歩, 鈴木慈, 津田雅貴, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, et al. リボヌクレオチドが誘発する奇異突然変異とその防御機構. 日本遺伝学会大会プログラム・予稿集. 2018. 90th

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Work history (4)：

2006/04 - - 現職
2005/04 - 2006/03 (独)産業技術総合研究所産総研特別研究員
2004/04 - 2005/03 ニューヨーク州立大学医学部NIHポスドクフェロー
2003/04 - 2004/03 日本学術振興会特別研究員PD(京都大学地球環境学大学院所属)

Awards (4)：

2017 - Genes & Environment Best Paper Award
2015 - 日本環境変異原学会ベストプレゼンテーション賞
2013 - 日本環境変異原学会研究奨励賞
2005 - 日本環境変異原学会ベストプレゼンテーション賞

Association Membership(s) (2)：

日本分子生物学会 , 日本環境変異原学会

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