Takahashi Hisaaki

タカハシヒサアキ | Takahashi Hisaaki

Affiliation and department：
Job title： Senior Assistant Professor

Research field (1)： Pathobiochemistry

Research keywords (10)： Oct-3/4 , 腫瘍免疫 , 腫瘍幹細胞 , グリオブラストーマ , グリオーマ , 脳腫瘍 , マクロファージ , マイクログリア , Macrophage , Microglia

Research theme for competitive and other funds (12)：

2020 - 2024 腫瘍免疫の再活性化を可能にする悪性グリオーマ分子標的治療薬の開発
2015 - 2020 微弱蛍光の可視化と数値情報の提示によって脳腫瘍切除手術を支援するシステムの構築
2015 - 2019 Development of Oct-3/4 targeting drug for malignant glioma treatment
2011 - 2013 Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma
2011 - 2012 Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

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Papers (99)：

Junya Tanaka, Hisaaki Takahashi, Hajime Yano, Hiroshi Nakanishi. Generation of CSF1-Independent Ramified Microglia-Like Cells from Leptomeninges In Vitro. Cells. 2020. 10. 1
Jun Kuwabara, Akihiro Umakoshi, Naoki Abe, Yutaro Sumida, Shota Ohsumi, Eika Usa, Kana Taguchi, Mohammed E Choudhury, Hajime Yano, Shirabe Matsumoto, et al. Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model. Biochemical and biophysical research communications. 2018. 496. 2. 542-548
Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, et al. Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma. Stem cells international. 2018. 2018. 5387041-5387041
Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I. Shimizu, Yoshiaki Yano, Yoshito Ishizaki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda. High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats. METABOLIC BRAIN DISEASE. 2017. 32. 6. 2095-2104
Hitomi Aono, Mohammed Emamussalehin Choudhury, Hiromi Higaki, Kazuya Miyanishi, Yuka Kigami, Kohdai Fujita, Jun-ichi Akiyama, Hisaaki Takahashi, Hajime Yano, Madoka Kubo, et al. Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus. GLIA. 2017. 65. 11. 1833-1847

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MISC (40)：

山下大介, 近藤亨, 大上史朗, 高橋寿明, 末廣諭, 井上明宏, 高野昌平, 大西丘倫. ヒトグリオーマ幹細胞の腫瘍形成を抑制するmicroRNA-340の同定機能解析と標的分子の検索. Brain Tumor Pathology. 2014. 31. Suppl. 110-110
Daisuke Yamashita, Toru Kondo, Hisaaki Takahashi, Akihiro Inoue, Shohei Kohno, Hironobu Harada, Shiro Ohue, Takanori Ohnishi. IDENTIFICATION AND CHARACTERIZATION OF A NOVEL microRNA INVOLVED IN GLIOMAGENESIS. NEURO-ONCOLOGY. 2013. 15. 31-31
Hisaaki Takahashi, Yukako Kobayashi, Kana Sugimoto, Hajime Yano, Junya Tanaka. Oct-3/4 induces CpG demethylation in the MGMT promoter to induce temozolomide resistance in glioblastoma cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S201-S201
Yuki Hosokawa, Hisaaki Takahashi, Yuya Kawabe, Kana Sugimoto, Hajime Yano, Junya Tanaka. Oct-3/4 contributes to acquire anti-cancer drug resistance of glioblastoma cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S202-S202
Chisato Kawamoto, Hiromi Higaki, Tasuku Nishihara, Kana Sugimoto, Hitomi Aono, Hisaaki Takahashi, Hajime Yano, Junya Tanaka. Mechanisms underlying suppressive effects of bromvalerylurea on LPS-activated microglia/macrophages. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S248-S248

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Professional career (1)：

博士(医学) (大阪大学)

Work history (6)：

2016/05 - 現在 Hokuriku University Faculty of Pharmaceutical Sciences
2014/06 - 2016/04 Asahikawa Medical University School of Medicine
2013/10 - 2014/05 Ehime University Graduate School of Medicine
2012/08 - 2013/09 愛媛大学医学部付属病院先端医療創世センター講師
2005/04 - 2012/07 Ehime University Graduate School of Medicine

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