Art

J-GLOBAL ID：201902229699844565   Reference number：19A2107878

Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

腫瘍浸潤における高レベルのCD44を発現する腫瘍周辺における神経膠腫幹様細胞の重要性,早期進行,および膠芽腫における予後不良【JST・京大機械翻訳】

Author (15)： Nishikawa Masahiro (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Inoue Akihiro (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Ohnishi Takanori (Department of Neurosurgery, Washoukai Sadamoto Hospital, Matsuyama, Ehime 790-0052, Japan) ,  Kohno Shohei (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Ohue Shiro (Department of Neurosurgery, Ehime Prefectural Central Hospital, Matsuyama, Ehime 790-0024, Japan) ,  Matsumoto Shirabe (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Suehiro Satoshi (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Yamashita Daisuke (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Ozaki Saya (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Watanabe Hideaki (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Yano Hajime (Department of Molecular and Cellular Physiology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Takahashi Hisaaki (Division of Pathophysiology, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Ishikawa 920-1180, Japan) ,  Kitazawa Riko (Division of Diagnostic Pathology, Ehime University Hospital, Toon, Ehime 791-0295, Japan) ,  Tanaka Junya (Department of Molecular and Cellular Physiology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan) ,  Kunieda Takeharu (Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan)
Material： Stem Cells International (Web)
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7828A  ISSN： 1687-966X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Glioblastoma multiforme (GBM) ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2107878&from=J-GLOBAL&jstjournalNo=U7828A") }}

Thesaurus term： culture (biology) ,  blood vessel ,  *Prognosis ,  *tumor ,  Phenotype ,  Recurrence ,  *CD44 antigen ,  stem cell ,  human ,  lumpectomy ,  *glioblastoma ,  *tumor invasion ,  excision ,  migration ,  niche
Semi thesaurus term： 腫瘍進行 ,  *予後不良 , 【Automatic Indexing@JST】

JST classification (2)： Cell physiology in general  (EF02010S) ,  Tumors(=neoplasms)of nervous system  (GN04000V)

Reference (46)：

• R. Stupp, M. E. Hegi, W. P. Mason, M. van den Bent, M. J. Taphoorn, R. C. Janzer, S. K. Ludwin, A. Allgeier, B. Fisher, K. Belanger, P. Hau, A. A. Brandes, J. Gijtenbeek, C. Marosi, C. J. Vecht, K. Mokhtari, P. Wesseling, S. Villa, E. Eisenhauer, T. Gorlia, M. Weller, D. Lacombe, J. G. Cairncross, R. O. Mirimanoff, European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups, National Cancer Institute of Canada Clinical Trials Group, "Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial," The Lancet Oncology, vol. 10, no. 5, pp. 459-466, 2009.
• S. K. Singh, C. Hawkins, I. D. Clarke, J. A. Squire, J. Bayani, T. Hide, R. M. Henkelman, M. D. Cusimano, P. B. Dirks, "Identification of human brain tumour initiating cells," Nature, vol. 432, no. 7015, pp. 396-401, 2004.
• R. Galli, E. Binda, U. Orfanelli, B. Cipelletti, A. Gritti, S. de Vitis, R. Fiocco, C. Foroni, F. Dimeco, A. Vescovi, "Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma," Cancer Research, vol. 64, no. 19, pp. 7011-7021, 2004.
• A. Giese, T. Kucinski, U. Knopp, R. Goldbrunner, W. Hamel, H. M. Mehdorn, J. C. Tonn, D. Hilt, M. Westphal, "Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma," Journal of Neuro-Oncology, vol. 66, no. 3, pp. 351-360, 2004.
• J. Oh, A. Sahgal, P. Sanghera, M. N. Tsao, P. Davey, K. Lam, S. Symons, R. Aviv, J. R. Perry, "Glioblastoma: patterns of recurrence and efficacy of salvage treatments," The Canadian Journal of Neurological Sciences, vol. 38, no. 4, pp. 621-625, 2011.

Terms in the title (13)： 腫瘍浸潤 ,  高レベル ,  CD44 ,  発現 ,  腫瘍 ,  周辺 ,  神経膠腫 ,  幹 ,  細胞 ,  重要性 ,  早期 ,  膠芽腫 ,  予後不良