Ogiwara Ikuo

オギワライクオ | Ogiwara Ikuo

Affiliation and department：

Research field (1)： Neuroscience - general

Research theme for competitive and other funds (9)：

2020 - 2024 多面的アプローチによる難治性てんかんの分子病態に基づく革新的創薬基盤研究
2019 - 2022 Proteins interacting with Nav1.1 may be potential therapeutic targets for epilepsy
2016 - 2018 Analysis of interacting-partners of Nav1.1 in premature mouse brain
2013 - 2015 Molecular pathophysiology of neurodevelopmental disorders associated with mutations in the genes encoding voltage-gated sodium channels
2011 - 2012 Molecular pathology of neurodevelopmental disorders associated with mutations of voltage-gated sodium channel gene

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Papers (35)：

Atsushi Shimohata, Dilip Rai, Takumi Akagi, Sumiko Usui, Ikuo Ogiwara, Makoto Kaneda. The intracellular C-terminal domain of mGluR6 contains ER retention motifs. Molecular and Cellular Neurosciences. 2023. 126. 103875
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, et al. Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons. eLife. 2023. 12. 87495
Dilip Rai, Takumi Akagi, Atsushi Shimohata, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Yuko Wada-Kiyama, Ikuo Ogiwara, Makoto Kaneda. Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6. Journal of Neurochemistry. 2021. 158. 4. 837-848
Tetsushi Yamagata, Matthieu Raveau, Kenta Kobayashi, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Ikuo Ogiwara, Shigeyoshi Itohara, Takao K Hensch, Kazuhiro Yamakawa. CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. Neurobiology of Disease. 2020. 141. 104954-104954
Hiroyuki Miyamoto, Tetsuya Tatsukawa, Atsushi Shimohata, Tetsushi Yamagata, Toshimitsu Suzuki, Kenji Amano, Emi Mazaki, Matthieu Raveau, Ikuo Ogiwara, Atsuko Oba-Asaka, et al. Impaired cortico-striatal excitatory transmission triggers epilepsy. Nature Communications. 2019. 10. 1. 1917

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MISC (46)：

下畑充志, 赤木巧, 荻原郁夫, 金田誠. 代謝型グルタミン酸6型受容体の細胞内輸送に関与するC末端特異的配列の探索. 日本神経化学会大会抄録集(Web). 2022. 65th
赤木巧, 下畑充志, 荻原郁夫, 金田誠. 代謝型グルタミン酸受容体6型の細胞膜表面局在に関するN型糖鎖修飾の役割. 日本神経化学会大会抄録集(Web). 2022. 65th
荻原郁夫, 尹成珠, 下畑充志, 雁木美衣, 金田誠. 電位依存性ナトリウムチャネルNav1.1と線維芽細胞増殖因子相同因子の相互作用. 日本神経化学会大会抄録集(Web). 2022. 65th
Atsushi Shimohata, Dilip Rai, Takumi Akagi, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Yuko Wada-Kiyama, Ikuo Ogiwara, Makoto Kaneda. The C-terminal domain is required for mGluR6 cell-surface localization. The FASEB Journal. 2021. 35. S1
赤木巧, 石井俊行, 荻原郁夫, 金田誠. 代謝型グルタミン酸6型受容体の細胞膜発現におけるC末端領域の役割. 日本医科大学医学会雑誌. 2019. 15. 4. 254-254

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Lectures and oral presentations (15)：

電位依存性ナトリウムチャネルNav1.1と相互作用するタンパクの探索
(てんかん研究 2017)
SCN1A遺伝子変異とてんかん原性 Dravet症候群とGEFS+の病態解明にむけて Scn1a変異マウスを用いた病態研究(Dravet症候群のモデルとして)
(てんかん研究 2017)
パルブアルブミン陽性細胞特異的Scn 1a遺伝子破壊マウスに認められた社会的行動異常と空間記憶学習障害
(てんかん研究 2015)
Dravet症候群成因解明のためのScn1a遺伝子発現可視化マウスの解析
(てんかん研究 2014)
海馬パルブアルブミン抑制性神経細胞におけるNav1.1発現低下がけいれん発作を生じる
(脳と発達 2014)

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Professional career (1)：

Work history (6)：

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Awards (4)：

2017/03 - The Japan Epilepsy Research Foundation Research Award
2014/10 - The Japan Epilepsy Society Juhn and Mary Wada Prize
2013/06 - 日本小児神経学会第55回日本小児神経学会総会若手優秀演題賞パルブアルブミン陽性細胞を標的としたScn1a遺伝子破壊はマウスにてんかん発作と運動失調を引き起こす
2008/05 - 日本小児神経学会第50回日本小児神経学会総会優秀ポスター賞電位依存性ナトリウムチャネルα1(SCN1A)遺伝子変異とてんかん

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