Yamagata Tetsushi

ヤマガタテツシ | Yamagata Tetsushi

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (4)：

2010 - 2011 Survey of the genetic modifier for Dravet syndrome
2008 - 2009 Development of gene therapy for SMEI using epilepsy model mouse.
2006 - 2007 Investigation of modifiers for epilepsy by using mouse models
2002 - 2004 Functional analysis of MHC class I molecules in the neuronal cells of central nervous

Papers (16)：

Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, et al. Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons. eLife. 2023. 12
Tetsushi Yamagata, Matthieu Raveau, Kenta Kobayashi, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Ikuo Ogiwara, Shigeyoshi Itohara, Takao K Hensch, Kazuhiro Yamakawa. CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. Neurobiology of disease. 2020. 141. 104954-104954
Hiroyuki Miyamoto, Tetsuya Tatsukawa, Atsushi Shimohata, Tetsushi Yamagata, Toshimitsu Suzuki, Kenji Amano, Emi Mazaki, Matthieu Raveau, Ikuo Ogiwara, Atsuko Oba-Asaka, et al. Impaired cortico-striatal excitatory transmission triggers epilepsy. Nature Communications. 2019. 10. 1. 1917
Ikuo Ogiwara, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Tetsushi Yamagata, Tojo Nakayama, Nafiseh Atapour, Eriko Miura, Emi Mazaki, Sara J. Ernst, Dezhi Cao, et al. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Communications Biology. 2018. 1. 1
Tetsushi Yamagata, Ikuo Ogiwara, Emi Mazaki, Yuchio Yanagawa, Kazuhiro Yamakawa. Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 491. 4. 1070-1076

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MISC (10)：

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Lectures and oral presentations (4)：

Detailed distribution analysis of epilepsy/neurodevelopmental disorder proteins Nav1.1 and Nav1.2
(2023)
ナトリウムチャネルNav1.1の大脳皮質5層錐体路投射細胞における発現はドラべ症候群における突然死神経回路を明らかにする
(第45回日本神経科学大会 (沖縄) 2022)
Nav1.1分布解析とNav1.1発現量増加によるドラべ症候群遺伝子治療の試み
(第54回日本てんかん学会学術集会 2021)
環状20番染色体症候群の遺伝子研究
(第38回日本てんかん学会学術集会 2004)

Professional career (1)：

Work history (4)：

2020/04 - 現在 Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences Department of Neurodevelopmental Disorder Genetics
2004/04 - 2020/03 理化学研究所脳神経科学研究センター神経遺伝研究チームチーム研究員
2001/04 - 2003/09 東海大学医学部分子生命科学2 特任助手
1998/04 - 2001/03 東海大学医学部分子生命科学2 奨励研究員

Awards (1)：

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