Hirabayashi Yoko

ヒラバヤシヨウコ | Hirabayashi Yoko

Affiliation and department：
Job title： Director

Research field (3)： Experimental pathology , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (8)： Hematopathology , Molecular Toxicology , 細胞周期 , 生体異物相互作用 , 造血幹細胞 , Cell cycle , Xenobiotic response , Hematopoietic stem cell

Research theme for competitive and other funds (16)：

2009 - 2011 Toxicity mechanism in hematopoietic stem/progenitor-derived signaling via aryl hydrocarbon receptors induced by benzene exposure
2008 - 2011 Mechanism underlying functional impairment of hematopoietic stem cell niches caused by oxidative stress at the site of xenobiotic interrelationship
2006 - 2008 Biological function of aryl hydrocarbon receptors in the hematopoietic progenitor cells with respect to a possible toxicologic mechanism
2004 - 2006 Oxidative stress-related xenobiotic responsive molecule : Study using mice with modified thioredoxin gene expression.
2003 - 2005 Mechanism of benzene-induced hematopoietic disturbances mediated by arylhydrocarbon receptors

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Papers (70)：

Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno. Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal dependent and independent pathways. Development (Cambridge, England). 2021
Eiichi Yamamoto, Yuhji Taquahashi, Makiko Kuwagata, Hirokatsu Saito, Kohei Matsushita, Takeshi Toyoda, Futoshi Sato, Satoshi Kitajima, Kumiko Ogawa, Ken-Ichi Izutsu, et al. Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging. International journal of pharmaceutics. 2021. 595. 120241-120241
Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, Yoko Hirabayashi. Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4. Toxicology reports. 2020. 7. 685-692
Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, Yoko Hirabayashi. Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4. Toxicology Reports. 2020. 7. 685-692
Shin-Ichi Oka, Adave Chin, Ji Yeon Park, Shohei Ikeda, Wataru Mizushima, Guersom Ralda, Peiyong Zhai, Mingming Tong, Jaemin Byun, Fan Tang, et al. Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart. Cardiovascular research. 2019. 116. 10. 1742-1755

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MISC (14)：

Yukuto Yasuhiko, Yoko Hirabayashi, Ryuichi Ono. Tbx6 regulates gene expression via binding sites in Long Terminal Repeats (LTR) of endogenous retrovirus during mouse embryogenesis. MECHANISMS OF DEVELOPMENT. 2017. 145. S112-S113
Yoko Hirabayashi. Radiation-induced, cell cycle-related gene expression in aging hematopoietic stem cells: enigma of their recovery. Annals of the New York Academy of Sciences. 2014. 1310. 69-73
Yoko Hirabayashi, Isao Tsuboi, Byung-Il Yoon, Jun Kanno, James Trosko, Tohru Inoue. Role Of Connexin 32 In Hematopoiesis: Maintaining Quiescence Of Hematopoietic Stem Cells and Their Proliferation. BLOOD. 2013. 122. 21
Yoko Hirabayashi, Byung-IL Yoon, Isao Tsuboi, Jun Kanno, James Trosko, Tohru Inoue. ROLE OF CONNEXIN 32: MAINTENANCE OF CELL QUIESCENCE AND SUPPORT OF PROLIFERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS. EXPERIMENTAL HEMATOLOGY. 2012. 40. 8. S126-S127
Y. Hirabayashi, B. I. Yoon, K. Igarashi, Y. Kodama, K. Sekita, T. Kaneko, J. Kanno, T. Inoue. Strain differences of the effect of benzene exposure: Microarray study of the bone marrow in C57BL/6 and C3H/He mice. TOXICOLOGY LETTERS. 2010. 196. S175-S175

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Education (2)：

1986 - 1991 Yokohama City University Graduate School for Medical Science Pathology & Molecular Hematology
1980 - 1986 Yokohama City University School of Medicine

Professional career (1)：

MD (Yokohama City University, School of Medicine)

Committee career (2)：

2021/05 - 現在日本動物実験代替法学会代議員
2020/07 - 現在日本実験動物学会評議員

Association Membership(s) (14)：

The Japanese Society for Anternatives to Animal Experiments , JAPANESE SOCIETY FOR FOOD HYGIENE AND SAFETY , 日本実験動物学会 , Japanese Society of Food Chemistry , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY , Society of Toxicology , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF TOXICOLOGY , International Society for Stem Cell Research , American Society of Hematology , THE JAPANESE SOCIETY OF PATHOLOGY

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