Rchr
J-GLOBAL ID：200901017150818697   Update date: Oct. 31, 2024

Kakuta Hiroki

カクタ ヒロキ | Kakuta Hiroki
Affiliation and department：
Okayama University

About Okayama University


Job title： Associate Professor
Other affiliations (1)：
  • 合成医薬品開発学
Homepage URL  (2)： http://www.cc.okayama-u.ac.jp/~kakuta-h/kakuta_lab/index.html ,  http://www.cc.okayama-u.ac.jp/~kakuta-h/kakuta_lab_english/index.html
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (16)： retinoids ,  Medicinal chemistry ,  Boron Neutron Capture Therapy ,  潰瘍性大腸炎 ,  希少疾病 ,  鎮痛 ,  抗アレルギー ,  抗炎症 ,  アラキドン酸カスケード ,  核内受容体 ,  脂質代謝制御物質創製 ,  physiologically active substance ,  nucear receptor ,  anti-inflammatory drug ,  differentiation inducer ,  antitumor drug
Research theme for competitive and other funds  (8)：
  • 2019 - 2022 Creation of new agents for BNCT that enable to measure boron concentration at tumor site
  • 2015 - 2017 Establishment of in vivo imaging and quantification of articular cartilage by using a cartilage-specific probe.
  • 2013 - 2017 Development of the strategy for fundamental therapy of cancer using iPS derived Cancer Stem cell models
  • 2013 - 2016 Exploratory research of high activity metal complexes by organic and inorganic nano-composite with anti-diabetic effect
  • 2013 - 2015 Creation of articular cartilage-specific bio-molecular imaging probe with potentials of dual modalities.
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Papers (81)：
  • Daisuke Imai, Nobutaka Numoto, Hiroaki Tokiwa, Hiroki Kakuta, Nobutoshi Ito. Structural basis for the full and partial agonist activities of retinoid X receptor α ligands with an iso-butoxy and an isopropyl group. Biochemical and biophysical research communications. 2024. 734. 150617-150617
  • Yukina Tanaka, Michiko Fujihara, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Makoto Makishima, Hiroki Kakuta. Simple Fluorescence Labeling Method Enables Detection of Intracellular Distribution and Expression Level of Retinoid X Receptors. ACS Medicinal Chemistry Letters. 2024
  • Kizuku Miura, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Hiroki Kakuta. Direct evaluation of polarity of the ligand binding pocket in retinoid X receptor using a fluorescent solvatochromic agonist. Bioorganic & medicinal chemistry letters. 2023. 96. 129536-129536
  • Mayu Kawasaki, Tomoharu Motoyama, Shoya Yamada, Masaki Watanabe, Michiko Fujihara, Akira Kambe, Shogo Nakano, Hiroki Kakuta, Sohei Ito. Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN. ACS Medicinal Chemistry Letters. 2023. 14. 3. 291-296
  • Susumu Kodama, Shuzo Matsumoto, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Atsushi Ono, Hiroki Kakuta. Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha. Toxicology letters. 2022. 373. 76-83
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MISC (82)：
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Patents (14)：
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Books (3)：
  • MEDCHEM NEWS
    2022
  • 現代化学
    東京化学同人 2007
  • ファルマシア6月号
    社団法人日本薬学会 2004
Lectures and oral presentations  (40)：
  • A Green and Scale-up Synthesis of Retinoid X Receptor Agonist NEt-3IB
    (PacifiChem2021)
  • GatekeeperレチノイドX受容体アンタゴニストCBTF-EEを骨格とする新規蛍光性RXRアンタゴニストの創出とリガンド結合試験法への展開
    (日本ビタミン学会第73回大会 2021)
  • RXRアゴニスト NEt-3IPの抗アレルギー作用について
    (日本薬学会第129年会 2010)
  • チアゾリジンジオン骨格を有する新規選択的血管新生阻害剤GPU-4の開発 発表形式:ポスター
    (日本薬学会第129年会 2010)
  • 新規レチノイドX受容体アゴニスト NEt-3IP のラットにおける体内動態評価
    (日本薬学会第129年会 2010)
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Education (5)：
  • - 2003 The University of Tokyo
  • - 2003 The University of Tokyo
  • - 2003 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1997 Okayama University Faculty of Pharmaceutical Sciences
  • - 1997 Okayama University Faculty of Pharmaceutical Science
Professional career (2)：
  • Ph.D.
  • 博士(薬学) (東京大学)
Work history (10)：
  • 2021/04 - Okayama University Medicine, Dentistry and Pharmaceutical Sciences, Institute of Academic and Research Associate Professor
  • 2021/04 - The Open University of Japan
  • 2008/10 - 2021/03 Okayama University Graduate school of Medicine, Dentistry and Pharmaceutical Sciences
  • 2007 - 2008 岡山大学医歯薬学総合研究科 助教
  • 2007 - 2008 Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
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Committee career (3)：
  • 2020/06 - 現在 日本ビタミン学会 幹事
  • 2018/06 - 現在 日本ビタミン学会 代議員
  • 2014 - 現在 日本ビタミン学会 トピックス編集委員
Awards (6)：
  • 2020/07 - Okayama Foundation for Science and Technology The Uchiyama Yuzo Science and Technology Award
  • 2015/07 - Okayama Foundation for Science and Technology Science and Technology Award in Okayama Foundation of Science and Technology
  • 2015/06 - 日本ビタミン学会 日本ビタミン学会賞(奨励賞) レチノイドX受容体を標的とした創薬に関する研究
  • 2012/02 - Okayama University 2011 Young Top Researcher Award
  • 2010/11 - Award for Excellent General Presentation in the Medicinal Chemistry Symposium
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Association Membership(s) (4)：
日本生化学会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American chemical society ,  The Vitamin Society of Japan
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