2015 - 2017 GENERATION OF LUNG ORGAN FROM EMBRYONIC STEM CELLS VIA BLASTOCYST COMPLEMENTATION IN MIC
2014 - 2017 Exploring the regulatory mechanism of hypothalamic local circuitry using a mouse line for visualizing CRF neurons by a fluorescent protein
2014 - 2017 Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variant
2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning
2012 - 2017 Molecular-anatomical research on multi-modal regulation of synaptic transmission in higher brain regions
2014 - 2016 Development of applicable methods for one-step generation of genetically modified mammals specialized in brain function analysis
2010 - 2016 Comprehensive Brain Science Network
2012 - 2016 Development of new methods for a gene-manipulated rat for the analysis of human brain function
2012 - 2015 Role of activity-dependent gene Arc in synaptic plasticity
2011 - 2015 Generation of new model mice for brain tumors usuing conditional knockout method
2012 - 2014 A new multitasking gene specifically developed for the analysis of brain functions
2011 - 2014 ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?
2009 - 2014 Mechanisms and physiological roles of electro-chemical Coupling mediated by voltage-sensor domain proteins
2011 - 2013 Regulatory mechanism for processing acute stress responses in the hypothalamus by prolacin-releasing peptide
2010 - 2011 Research on regulatory systems of NMDA receptor activity by GluN2B in neurons
2009 - 2011 Glutamate receptor dynamism in the brain functions and diseases
2007 - 2011 Molecular mechanisms for calcium-mediated refinement of competitive synaptic wiring in the brain
2009 - 2010 iPS細胞技術を用いたノックアウトラット作製法の確立
2008 - 2010 Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism
2008 - 2009 脳機能解析に最適化した遺伝子改変マウス作成システムの構築
2005 - 2009 Studies on activity-dependent maturation of synaptic function during postnatal cerebellar development
2005 - 2008 Elucidation of the mechanisms and physiological significance of endocannabinoid-mediated retrograde synaptic modulation
2005 - 2007 Generation of model mice for brain tumors using conditional knockout technique
2005 - 2007 Molecular mechanism of the synaptic targeting and activity regulation of glutamate receptors
2005 - 2006 虚血条件付けの脳保護機序におけるNMDA受容体εサブユニット分子種の役割
2005 - 2005 コンディショナルターゲティング法を用いた脳機能解析モデルマウスの作成
2003 - 2004 遺伝子組換え法を用いた神経回路形成・調節機序の分子解析
2001 - 2003 Molecular mechanisms of gaseous anesthetics on glutamate receptors : Identification of action site and examination of anesthetic behaviors in knock-out mice
2001 - 2003 Molecular analysis of higher brain functions using conditional gene targeting
2001 - 2002 系統的ES細胞株樹立法の開発
2001 - 2002 神経回路の形成、維持、変化における細胞接着分子の役割
2001 - 2001 時間空間特異的な遺伝子発現制御系を用いた記憶・学習の分子機構の解明
2000 - 2001 Molecular Biological Study on Mechanism of Neuronal Cell Death and Establishment of New Therapy in Glaucoma
2000 - 2000 時間空間特異的な遺伝子発現制御系を用いた記憶・学習の分子機構の解明
2000 - 2000 神経回路の形成、維持、変化における細胞接着分子の役割
1999 - 2000 神経可塑性における転写後調節の役割
1999 - 2000 Structural and functional characterization of a novel Polycomb group gene SCML1.
1998 - 2000 Molecular mechanisms of general anesthetics on glutamate receptor channels : Identification of a site of action and examination of anesthetic behaviors in knock-out mice
1998 - 2000 Generation of mouse models of human neurological disorders
1998 - 2000 Functional analysis of the molecular mechanism of synaptic plasticity using conditional gene targeting
1999 - 1999 発生工学を用いた神経細胞壊死の機構解析
1998 - 1998 発生工学を用いた神経細胞壊死の機構解析
1995 - 1998 Synaptic receptors and plasticity
1997 - 1997 発生工学を用いた神経細胞壊死の機構解析
1997 - 1997 神経回路形成におけるNMDA受容体チャネルの役割
1996 - 1997 Physiological Roles of the NMDA Receptor Channel in Brain Function
1996 - 1996 興奮性アミノ酸による神経細胞壊死の分子機構
1995 - 1995 脳高次機能におけるグルタミン酸受容体チャネルの役割
1995 - 1995 興奮性アミノ酸による神経細胞壊死の分子機構
1994 - 1994 脳高次機能におけるグルタミン酸受容体チャネルの役割
1993 - 1994 Preparation of mutant mice defective in the NMDA receptor channel
1992 - 1994 Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure
Yasuhiro Funahashi, Rijwan Uddin Ahammad, Xinjian Zhang, Emran Hossen, Masahiro Kawatani, Shinichi Nakamuta, Akira Yoshimi, Minhua Wu, Huanhuan Wang, Mengya Wu, et al. Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning. Science signaling. 2024. 17. 853. eado9852
Yoshika Hayakawa-Yano, Takako Furukawa, Tsuyoshi Matsuo, Takahisa Ogasawara, Masahiro Nogami, Kazumasa Yokoyama, Masato Yugami, Munehisa Shinozaki, Chihiro Nakamoto, Kenji Sakimura, et al. Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 37. e2401531121
Hiroaki Taketsuru, Runa Hirayama, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Manabu Abe, Kenji Sakimura. Generation of rat offspring from ovarian oocytes by xenotransplantation. Scientific reports. 2024. 14. 1. 20109-20109
Takafumi Kawai, Shin Morioka, Haruhiko Miyata, Rizki Tsari Andriani, Sharmin Akter, Gabriel Toma, Tatsuya Nakagawa, Yuki Oyama, Rie Iida-Norita, Junko Sasaki, et al. The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Nature Communications. 2024. 15. 1
Jitrapa Pinyomahakul, Masataka Ise, Meiko Kawamura, Takashi Yamada, Kentaro Okuyama, Shinsuke Shibata, Jun Takizawa, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi. Analysis of Brain, Blood, and Testis Phenotypes Lacking the Vps13a Gene in C57BL/6N Mice. International Journal of Molecular Sciences. 2024. 25. 14. 7776-7776
赤荻悠太, 金光明音, 浜本洋, 崎村建司, 内野茂夫. Screening of molecules responsible for various social behaviors exhibited in model mice of autism spectrum disorder. 日本生物学的精神医学会(Web). 2022. 44th
大川藍, 金光明音, 弓下美春, 平井七星, 泉彩人, 崎村建司, 内野茂夫. Establishment of index for various behavioral patterns shown in model mice of autism spectrum disorder. 日本生物学的精神医学会(Web). 2022. 44th
2018/04 - 現在 Brain Research Institute, Niigata University Dept. of Animal Model Development Fellow
1996/06 - 2018/03 Brain Research Institute, Niigata University Dept. of Cellular Neurobiology Professor
1991/01 - 1996/05 Brain Research Institute, Niigata University Dept. of Neuropharmacology Associate professor
1983/05 - 1990/12 Brain Research Institute, Niigata University Dept. of Neuropharmacology Research associate
Association Membership(s) (7)：
THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, International Society for Neurochemistry (ISN)
, Society for Neuroscience (SfN)
, THE JAPAN NEUROSCIENCE SOCIETY
, THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
, THE JAPANESE BIOCHEMICAL SOCIETY
