TSUDA Hiromasa

ツダヒロマサ | TSUDA Hiromasa

Affiliation and department：
Job title： Associate Professor

Research field (5)： Community dentistry , Conservative dentistry and endodontics , Pathobiochemistry , Oral medicine , Oral medicine (pathology)

Research keywords (14)： Osteoblasts , Autophagy , Inorganic Polyphosphate , osteoclasts , Autoimmune Diseases , Rheumatoid Arthritis , Damage-associated molecular patterns , cellular death , Innate Immunity System , Short-Chain Fatty Acids , Three-dimensional gingival tissue culture , bones , gingival epithelium , Periodontitis

Research theme for competitive and other funds (14)：

2020 - 2022 ヒト歯肉オルガノイドを用いた歯肉炎症および自己免疫疾患誘導メカニズムの探索
2020 - 2022 口腔癌の新たなバイオマーカーとしてのエクソソームによる高感度診断法と治療法の開発
2018 - 2020 タンパク質分解酵素阻害因子(SLPI)によるがん病態の悪性化誘導機構の検討
2017 - 2019 三次元培養系を用いた歯周病由来関節リウマチ予防法の開発
2011 - 2014 食品成分誘導エピジェネティック制御による歯周炎予防法の開発

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Papers (29)：

Tadashi Masaoka, Keiji Shinozuka, Kenshin Ohara, Hiromasa Tsuda, Kenichi Imai, Morio Tonogi. Bioinformatics analysis of dysregulated exosomal microRNAs derived from oral squamous cell carcinoma cells. Journal of oral science. 2021. 63. 2. 174-178
Yui Fujiwara, Takahisa Murofushi, Ryosuke Koshi, Yoshikazu Mikami, Hiromasa Tsuda. Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure. Journal of oral science. 2021. 63. 2. 195-197
Hayata M, Watanabe N, Kamio N, Tamura M, Nodomi K, Tanaka K, Iddamalgoda A, Tsuda H, Ogata Y, Sato S, et al. Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells. J Nat Med. 2018. 73. 1. 114-123
Mikami Y, Omagari D, Mizutani Y, Hayatsu M, Ushiki T, Tsuda H. Dual effect of polyphosphate on mineralization of rat osteoblast ROS17/2.8 cells in a dose-dependent manner. J Pharmacol Sci. 2018. 138. 3. 209-213
Fujita S, Zama M, Kaneko K, Murayama S, Ohtani S, Usui M, Noma M, Tsuda H, Yamamoto K, Kobayashi M. Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study. Neuroscience Lett. 2018. 696. 87-92

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MISC (2)：

Ohtani, Saori, Fujita, Satoshi, Hasegawa, Koki, Tsuda, Hiromasa, Tonogi, Morio, Kobayashi, Masayuki. Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2018. 138. 1. 76-82
Hiromasa Tsuda. New leaisons between periodontal disease and rheumatoid arthritis. Medical Science Digest. 2017. 43. 13. 15-18

Patents (3)：

METHOD OF DETECTING STREPTOCOCCUS PNEUMONIAE, PRIMER SET FOR THE DETECTION AND KIT FOR THE DETECTION
LAMP primer sets for detection of Streptococcus mutans and Streptococcus sobrinus
Streptococcus pneumoniaeの検出方法Streptococcus pneumoniae検出用プライマーセット及びStreptococcus pneumoniae検出用キット

Books (1)：

Autophagy: Principles, Regulation and Roles in Disease
NOVA publishers 2012 ISBN:9781619422667

Lectures and oral presentations (48)：

Dominance of histone acetyltransferase is required for induction of short-ch ain fatty-acid-induced death of human gingival epithelial Ca9-22 cells
(第61回歯科基礎医学会学術大会 2019)
Transcriptome analysis of the effect of short-chain fatty acids on gingival epithelial cell death.
(第61回歯科基礎医学会学術大会 2019)
皮質体性感覚野における体部位局在性の可塑的変化と振動性興奮の抑制
(第77回東京矯正歯科学会大会 2018)
歯周病細菌の産生する短鎖脂肪酸はヒト歯肉上皮細胞の細胞死を誘導し関節リウマチ関連因子を放出する
(第59回歯科基礎医学会学術大会 2017)
歯周病細菌の産生する短鎖脂肪酸はヒト歯肉上皮細胞の細胞死を誘導し関節リウマチ関連因子を放出する
(第59回歯科基礎医学会学術大会 2017)

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Education (2)：

1996 - 2000 Kyushu university dental sciences dentistry
1990 - 1996 Kyushu Univresity Faculty of Dentistry Dentistry

Work history (11)：

2017/10 - 現在 Nihon University School of Dentistry Dept. Biochemistry Associate Professor
2010/03 - 2017/09 Nihon University School of Dentistry Dept. Biochemistry Assistant professor
2016/01 - 2016/03 Niigata University Faculty of Dentistry Lecturer
2007/04 - 2010/03 Chiba University General Education Course (English Reading, Listening and Speaking) Lecturer
2006/10 - 2010/02 Nihon Univ. School of Dentistry Dep. Biochemistry Assistant Professor

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Association Membership(s) (4)：

歯科基礎医学会 , 日本分子生物学会 , 日本抗加齢科学会 , International Association for Dental Research

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