Rchr
J-GLOBAL ID：200901028335486862   Update date: Oct. 05, 2024

Takata Minoru

タカタ ミノル | Takata Minoru
Affiliation and department：
Kyoto University Radiation Biology Center

About Kyoto University Radiation Biology Center


Job title： Professor
Other affiliations (1)：
Research field  (6)： Genomics ,  Medical biochemistry ,  Environmental effects of chemicals ,  Environmental effects of radiation ,  Immunology ,  Pathobiochemistry
Research keywords  (10)： Replication stress ,  genome stability ,  radiation biology ,  DNA repair ,  Hereditary Breast and Ovarian Cancer ,  Fanconi anemia ,  免疫細胞におけるシグナルトランスダクション ,  相同組換え ,  Signal transduction in immune cells ,  Homologons DNA recombination
Research theme for competitive and other funds  (42)：
  • 2020 - 2023 Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming
  • 2020 - 2023 The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks
  • 2015 - 2019 Next generation lung cancer mice model for conquering cancer stem
  • 2015 - 2017 新規ファンコニ貧血遺伝子のハンティングと機能解析
  • 2011 - 2016 The function of non-coding DNA for genome integrity
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Papers (172)：
  • Anfeng Mu, Yusuke Okamoto, Yoko Katsuki, Minoru Takata. The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway. DNA Repair. 2024. 103733-103733
  • Erin Alvi, Ayako L. Mochizuki, Yoko Katsuki, Minori Ogawa, Fei Qi, Yusuke Okamoto, Minoru Takata, Anfeng Mu. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response. Communications Biology. 2023
  • Anfeng Mu, Zimu Cao, Denggao Huang, Hiroshi Hosokawa, Shingo Maegawa, Minoru Takata. Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model. Molecular Biology Reports. 2023
  • Anfeng Mu, Asuka Hira, Minako Mori, Yusuke Okamoto, Minoru Takata. Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome: metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA Damage. DNA Repair. 2023. 103546-103546
  • Fei Qi, Erin Alvi, Minori Ogawa, Junya Kobayashi, Anfeng Mu, Minoru Takata. The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response. Genes to Cells. 2023
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MISC (79)：
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Books (6)：
  • 先天性骨髄不全症 診療ガイドライン
    診断と治療社 2017
  • 放射線医科学の事典
    医療科学社 2016
  • ゲノムを司るインターメア 非コードDNAの新たな展開
    化学同人 2015
  • 家族性腫瘍学 -家族性腫瘍の最新研究動向-増刊号6
    日本臨床社 2015
  • DNA Replication, Recombination, and Repair.
    Springer 2015
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Lectures and oral presentations  (113)：
  • Analysis of DNA damage repair by homologous recombination and the Fanconi anemia pathway.
    (International Particle Medicine Research Symposium IPMRS-2018-Takasaki 2018)
  • Chromosome stress due to endogenous DNA damage and Fanconi anemia
    (日本血液学会 JSH2018 2018)
  • The ubiquitination pathway that recruits the Fanconi anemia nuclease scaffold SLX4/FANCP.
    (Korean Society for Molecular and Cellular Biology. Symposium “Molecular Mechanisms to preserve Genomic Integrity.” 2018)
  • 家族性のがんの話
    (京都大学 研究連携基盤 丸の内セミナー 2018)
  • RNF168 mediates the recruitment of SLX4 via ubiquitination during ICL repair.
    (2018 IBS CONFERENCE IBS-KSMCB Conference on Genomic Interity &Cell Cycle June 2018)
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Education (2)：
  • - 1982 Okayama University Medical School Faculty of Medicine
  • - 1982 Okayama University Faculty of Medicine
Professional career (1)：
  • MD, PhD
Awards (4)：
  • 2021/09 - 日本放射線影響学会 学会賞 『相同DNA組換え分子機構とその欠損病態である「ファンコニ貧血」の病態解明』
  • 2017/09 - Fanconi Anemia Research Fund Discovery Award
  • 2015/09 - Fanconi Anemia Research Fund Discovery Award
  • 2009/12 - 日本白血病研究基金 荻村孝特別研究賞
Association Membership(s) (3)：
THE JAPANESE RADIATION RESEARCH SOCIETY ,  日本癌学会 ,  日本分子生物学会
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