Rchr
J-GLOBAL ID:200901028440136087
Update date: Sep. 03, 2024
Kazuko Kaneda-Nakashima
カネダーナカシマ カズコ | Kazuko Kaneda-Nakashima
Affiliation and department:
Job title:
Professor
Other affiliations (1):
-
Institute for Radiation Sciences
Interdisciplinary Research Center for Radiation Sciences
Professor
Homepage URL (1):
https://www.frc.sci.osaka-u.ac.jp
Research field (4):
Tumor biology
, Radiology
, Immunology
, Medical biochemistry
Research keywords (9):
Zinc transporter
, Aminoacid transporter
, Alpha emitting nuclides
, Astatine-211
, Radiation
, 転写因子
, 白血病
, transcriptional factor
, Leukemia
Research theme for competitive and other funds (16):
- 2024 - 2027 Development of innovative alpha therapy targeting cancer-associated fibroblasts
- 2021 - 2026 Interdisciplinary study for the development of dosimetry system for targeted alpha therapy
- 2021 - 2024 アルファ線を用いた切らない日帰りがん治療への挑戦
- 2021 - 2024 1分子ユニット内で放射線と蛍光を放出するイメージングプローブの開発
- 2020 - 2023 Targeted alpha therapy for patients with tumor
- 2019 - 2022 Development of Nuclear Medicine Therapy targeting Cancer Stroma
- 2019 - 2021 Development of stable and rapid reactive chlating agent for MRI and Targeted Alpha Therapy
- 2018 - 2021 Development of cancer missile therapy targeting amino acid transporter LAT1 by alpha emitting nuclide
- 2015 - 2017 Investigation of cancer specific survival system via LAT1/4F2hc-integrin complex
- 2013 - 2016 Analysis of ATL leukemogenesis through breakage of defense mechanism of HTLV-1 infection
- 2013 - 2015 Investigation of survival strategy of refractory leukemia via integrin
- 2012 - 2015 Investigation of MEL1/PRDM16 function in bone differentiation
- 2013 - 2013 新規白血病幹細胞マーカーを標的とした白血病治療法の検討
- 2011 - 2011 がん細胞接着阻害を利用した難治性白血病抗体療法の開発
- 2010 - 転写因子MEL1の新規機能解析
- 2010 - 転写因子EVI1を介した急性骨髄性白血病の発症メカニズムの解析
Show all
Papers (65):
-
Jyoti Jaiswal, Souta Mizushima, Saeka Kanno, Kazuma Sasaki, Kazuya Kabayama, Kazuko Kaneda-Nakashima, Yuichiro Tsuyuki, Kazuyoshi Tsuchiya. Highly sensitive on-skin flexible Sb2O3/Sb thin film pH sensor for real-time sweat sensing. Materials Research Bulletin. 2024. 175. 112795-112795
-
Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuichiro Kadonaga, Kazuhiro Ooe, Thosapol Sampunta, Naoki Hirose, Xiaojie Yin, Hiromitsu Haba, Yukiyoshi Kon, Atsushi Toyoshima, et al. Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer. International journal of molecular sciences. 2024. 25. 11
-
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Tadashi Watabe, Kazuhiro Ooe, Xiaojie Yin, Hiromitsu Haba, Kenji Shirasaki, Hidetoshi Kikunaga, Kazuaki Tsukada, et al. Comparison of Nuclear Medicine Therapeutics Targeting PSMA among Alpha-Emitting Nuclides. International Journal of Molecular Sciences. 2024. 25. 2. 933-933
-
Tadashi Watabe, Kazuya Kabayama, Sadahiro Naka, Ryuku Yamamoto, Kazuko Kaneda, Satoshi Serada, Kazuhiro Ooe, Atsushi Toyoshima, Yang Wang, Hiromitsu Haba, et al. Immuno-PET and Targeted α-Therapy Using Anti-Glypican-1 Antibody Labeled with89Zr or211At: A Theranostic Approach for Pancreatic Ductal Adenocarcinoma. Journal of Nuclear Medicine. 2023. jnumed.123.266313-jnumed.123.266313
-
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai. Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models. Scientific Reports. 2023. 13. 1. 13943-13943
more...
MISC (32):
-
兼田(中島) 加珠子, 樺山 一哉, 白神 宜史, 渡部 直史, 豊嶋 厚史, 深瀬 浩一. 進行がんや手術困難例に対する核医学治療薬の現状と新規治療薬の開発-Development of nuclear medicine for targeting alpha therapy to cancer. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会 編. 2023. 79. 3. 348-352
-
渡部 直史, 兼田 加珠子, 豊嶋 厚史, 深瀬 浩一. アスタチン(211At)標識PSMA5を用いた新規標的α線治療の評価 前立腺癌モデルでの検討(Evaluation of new targeted alpha therapy using astatine(211At) labeled PSMA5 for prostate cancer). 日本癌学会総会記事. 2022. 81回. J-1007
-
Kazuko Kaneda-Nakashima, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Yoshikatsu Kanai, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase. Development of short-lived alpha-emitting nuclear medicine aiming at minimally invasive cancer treatment. 日本癌学会総会記事. 2022. 81回. J-1008
-
渡部 直史, 兼田 加珠子, 白神 宜史, 角永 悠一郎, 大江 一弘, 王 洋, 羽場 宏光, 豊嶋 厚史, 深瀬 浩一. 211At標識PSMA-5を用いた標的アルファ線治療 非臨床での評価. 核医学. 2022. 59. Suppl. S464-S464
-
Kabayama Kazuya, Shirakami Yoshifumi, Kaneda Kazuko, Watabe Tadashi, Toyoshima Atsushi. Activities of Targeted Alpha Therapy at Osaka University. MEDCHEM NEWS. 2022. 32. 2. 93-98
more...
Patents (15):
Lectures and oral presentations (58):
-
アスタチン-211標識線維芽細胞活性化タンパク質阻害薬(FAPI)の合成およびα線核医学治療の検討
(第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会 2023)
-
[211At]PSMA5の非臨床試験:First-in-human医師主導治験開始に向けて
(第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会 2023)
-
前立腺がんの標的α線治療を目的とする[211At]PSMA5の製法と品質確立
(第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会 2023)
-
[211At]PSMA5の薬物動態試験ならびにヒト吸収線量の推定
(第63回日本核医学会学術総会・第43回日本核医学技術学会総会学術総会 2023)
-
希少がん治療を目指した短寿命アルファ線核医学治療薬の開発
(第82回日本癌学会学術総会 2023)
more...
Works (5):
-
インテグリンを介した白血病残存戦略の解明
2013 - 2015
-
MEL1/PRDM16による骨分化制御機構の解明
2012 - 2015
-
新規白血病幹細胞マーカーを標的とした白血病治療法の検討
2013 - 2014
-
がん細胞接着阻害を利用した難治性白血病治療抗体の開発
2013 - 2013
-
がん細胞接着阻害を利用した難治性白血病抗体療法の開発
2011 - 2012
Education (7):
- 2003 - 2006 Kyoto University Graduate School of Medicine
- - 2006 Kyoto University Graduate School, Division of Medicine
- 2001 - 2002 Osaka University Graduate School of Medicine
- 1999 - 2001 Osaka University Graduate School of Medicine
- - 2001 Osaka University Graduate School, Division of Medical Sciences
- 1995 - 1999 Osaka University Faculty of Human Sciences Bihavioral Sciences
- - 1999 Osaka University Faculty of Human Science Human Science, Behavioral Sciences
Show all
Professional career (2):
- Doctor of Public Health (Kyoto University)
- Medical Science (Osaka University)
Work history (10):
- 2022/04 - 現在 Graduate School of Science, Osaka University Forfront Research Center Professor
- 2018/12 - 2022/03 Osaka University Institute for Radiation Sciences Associate Professor
- 2017/03 - 2018/12 Osaka University Graduate School of Science Assistant professor
- 2014/09 - 2017/03 Osaka University Graduate School of Medicine, Assistant professor
- 2010/04 - 2015/03 University of Miyazaki Faculty of Medicine Assistant professor
- 2010/04 - 2015/03 Assistant Professor,Function control study course tumor biochemistry field,School of Madicine,Faculty of Madicine,University of Miyazaki
- 2008/04 - 2010/03 Osaka University Graduate School of Frontier Biosciences Postdoctoral fellow
- 2008/04 - 2010/03 Researcher,Osaka University
- 2006/04 - 2008/03 National Institute of Biomedical Innovation Laboratory of Gene Transfer and Regulation Postdoctoral fellow
- 2006/04 - 2008/03 Researcher
Show all
Committee career (2):
- 2023/11 - 現在 The Japanese Biochemical Society Representative (Kinki Branch)
- 2015/02 - 現在 トランスポーター研究会 幹事
Awards (5):
- 2022/09 - Dispersion of alpha-nuclides during Animal Experiments Japanese society of radiation safety management Technology award
- 2018/12 - 日本放射線安全管理学会 日本放射線安全管理学会 第17回 学術大会 優秀ポスター賞 動物実験における短寿命アルファ線核種の体内外の分布
- 2014/12 - 日本血液学会 第76回日本血液学会学術総会優秀ポスター賞
- 2012/10 - 日本血液学会 第74回日本血液学会学術総会優秀ポスター賞
- 2010/09 - 日本血液学会 第72回日本血液学会学術総会優秀ポスター賞
Association Membership(s) (7):
日本生化学会
, 日本血液学会
, 日本癌学会
, 日本分子生物学会
, 日本免疫学会
, 日本アレルギー学会
, JAPANESE SOCIETY OF RADIATION SAFETY MANAGEMENT
Return to Previous Page