Komeda Seiji

コメダセイジ | Komeda Seiji

Affiliation and department：
Homepage URL (1)： http://www.asahi-net.or.jp/~ij4s-kmd/

Research field (4)： Pharmaceuticals - analytical and physicochemistry , Structural biochemistry , Biochemistry , Inorganic and coordination chemistry

Research keywords (1)：制癌剤金属錯体 DNA NMR X線結晶解析

Research theme for competitive and other funds (9)：

2019 - 2022 Development of a next-generation platinum-based drug with a markedly high and long-lasting antitumor efficacy
2015 - 2018 Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity
2015 - 2015 難治性がんに有効な白金錯体と標的指向性 DDS を組み合わせた次世代がん治療薬の開発
2012 - 2015 Development of next-generation anticancer drugs using dinuclear transition metal complexes
2009 - 2010 Development of anticancer platinum complexes that recognize a specific region of nucleic acid.

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Papers (47)：

Masako Uemura, Keiichi Hiramoto, Hiroki Yoneyama, Shinya Harusawa, Seiji Komeda. Introduction of Fluorine into Antitumor-Active Dinuclear Platinum(II) Complexes Leads to Modulation of In Vivo Antitumor Activity in Mice. Inorganic chemistry. 2022. 61. 31. 12155-12164
Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa. Data on synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes. Data in brief. 2022. 40. 107697-107697
Toshifumi Kishimoto, Yuko Yoshikawa, Kenichi Yoshikawa, Seiji Komeda. Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression. International Journal of Molecular Sciences. 2020. 21. 34
Komeda Seiji, In Yasuko, Tomoo Koji, Minoura Katsuhiko, Sato Takaji, Reedijk Jan, Ishida Toshimasa, Chikuma Masahiko. Associative intraligand substitution of anticancer azolato-bridged compounds without a square-pyramidal intermediate: Formation of a unique tetranuclear, mu(3)-1,2,3-triazolato-N1,N2,N3-bridged Pt(II) compound. INORGANICA CHIMICA ACTA. 2019. 495
Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa. Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy. Journal of Inorganic Biochemistry. 2019. 192. 82-86

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MISC (3)：

Books (7)：

生命金属ダイナミクス : 生体内における金属の挙動と制御
エヌ・ティー・エス 2021 ISBN:9784860437060
図解腫瘍薬学
南山堂 2020 ISBN:9784525721619
パートナー分析化学II改定第3版
南江堂 2017 ISBN:9784524403431
NEW薬学機器分析第2版
廣川書店 2011 ISBN:9784567255745
レアメタル便覧
丸善 2011 ISBN:9784621082768

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Education (3)：

- 2002 Leiden University 化学研究科 Coordination and Bioinorganic Chemistry
- 1996 Osaka University of Pharmaceutical Sciences Graduate School of Pharmaceutical Sciences
- 1994 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph. D. (Leiden University)

Work history (8)：

2021/04 - 現在 Suzuka University of Medical Science Faculty of Pharmaceutical Sciences Professor
2014/04 - 2021/03 Suzuka University of Medical Science Faculty of Pharmaceutical Sciences Associate Professor
2008/04 - 2014/03 Suzuka University of Medical Science Faculty of Pharmaceutical Sciences Assistant Professor
2007 - Osaka University of Pharmaceutical Sciences
2004 - 米国 Georgia Institute of Technology NCI-日本学術振興会日米癌研究協力事業 Research Associate

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Awards (1)：

2010/09 - 第4回バイオ関連化学シンポジウム講演賞

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