Art

J-GLOBAL ID：201902257912773376   Reference number：19A0330418

Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy

テトラゾール架橋二核白金(II)錯体の合成と構造活性相関 テトラゾールC5における小さな修飾はin vivo抗腫瘍効果に顕著に影響する【JST・京大機械翻訳】

Author (8)： Komeda Seiji (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Yoneyama Hiroki (Department of Pharmaceutical Organic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Uemura Masako (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Tsuchiya Takahiro (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Hoshiyama Miyuu (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Sakazaki Tomoya (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Hiramoto Keiichi (Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan) ,  Harusawa Shinya (Department of Pharmaceutical Organic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan)
Material： Journal of Inorganic Biochemistry  (J Inorg Biochem)
Volume： 192  Page： 82-86  Publication year： 2019 
JST Material Number： D0908A  ISSN： 0162-0134  CODEN： JIBID  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We synthesized and characteriz...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A0330418&from=J-GLOBAL&jstjournalNo=D0908A") }}

Thesaurus term： cisplatin ,  *platinum complex ,  mouse(animal) ,  *antitumor action ,  rectal neoplasm ,  *structure-activity relationship ,  lymphocyte ,  homotransplantation ,  colon ,  characterization ,  sensitivity ,  cytotoxicity ,  effectiveness
Semi thesaurus term： オキサリプラチン ,  *テトラゾール類 , 【Automatic Indexing@JST】

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (9)： テトラゾール ,  架橋 ,  核 ,  白金 ,  錯体 ,  構造活性相関 ,  C5 ,  修飾 ,  抗腫瘍効果