Rchr
J-GLOBAL ID:200901036292404916
Update date: Jan. 30, 2024
Siomi Haruhiko
シオミ ハルヒコ | Siomi Haruhiko
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://siomilab.med.keio.ac.jp/
Research field (1):
Genetics
Research keywords (2):
RNA-binding protein, small RNA, transposable elements, RNA silencing, RNAi
, RNA-binding protein
Research theme for competitive and other funds (10):
- 2019 - 2024 Understanding of totipotency through characterization of interactions between transposable elements and early embryos
- 2019 - 2024 Program for Totipotency
- 2014 - 2018 Elucidation of molecular mechanisms of RNA silencing
- 2013 - 2018 霊長類を含む哺乳動物の生殖エピゲノム形成機構
- 2008 - 2013 転移因子とArgonauteの軍拡競争からゲノムの進化を探る
- 2003 - 2008 遺伝性精神遅滞症遺伝子FMR1の解析を通して知る脳内行動発現ネットワーク機構
- 2001 - 2007 Spatiotemporal Network of RNA Information Flow
- 2002 - 2006 Regulation of the expression of genome information by RNA-binding proteins
- 2001 - 2005 RNA結合タンパク質の発現異常に伴うヒト遺伝病の分子機能解析
- Cell biological approach to understanding functions of RNA-binding proteins
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Papers (131):
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Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nature Genetics. 2023
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Setsuko Mise-Omata, Mari Ikeda, Masaru Takeshita, Yoshifumi Uwamino, Masatoshi Wakui, Tomoko Arai, Ayumi Yoshifuji, Kensaku Murano, Haruhiko Siomi, Kensuke Nakagawara, et al. Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. Journal of immunology (Baltimore, Md. : 1950). 2022. 209. 11. 2104-2113
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Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Toshiki Takenouchi, Shunsuke Uno, Makoto Ishii, Takahiro Maruno, et al. Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19. Scientific Reports. 2022. 12. 1. 1299-1299
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Ten D Li, Kensaku Murano, Tomohiro Kitano, Youjia Guo, Lumi Negishi, Haruhiko Siomi. TDP-43 safeguards the embryo genome from L1 retrotransposition. Science advances. 2022. 8. 47. eabq3806
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Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki. Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers. Nucleic acids research. 2022. 50. 20. 11580-11599
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MISC (17):
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大西遼, 佐藤薫, 村野健作, 根岸瑠美, 塩見春彦, 塩見美喜子. PiwiはMaelstromを介してBrm依存的なトランスポゾンを抑制する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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村野健作, GUO Youjia, 川口敦史, 竹下勝, 山下暁朗, 塩見春彦. SARS-CoV-2感染を阻害する強力なマウスモノクローナル抗体. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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大西遼, 佐藤薫, 村野健作, 高橋亜紀子, 根岸瑠美, 塩見春彦, 塩見美喜子. piRNAを介したトランスポゾン転写抑制機構におけるMaelとBrmの機能. 日本RNA学会年会要旨集. 2019. 21st
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小野口真広, 足達俊吾, 塩見春彦. 細胞がトランスクリプトームからpiRNA前駆体を識別する仕組みの理解. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
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岩崎由香, 塩見春彦, 齋藤都暁. PiwiはヒストンH1を介したクロマチンの構造の制御により標的となるトランスポゾンを抑制する. ライフサイエンス 新着論文レビュー FIRST AUTHOR'S. 2016
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Education (3):
- - 1988 Kyoto University Graduate School of Medicine
- - 1984 Gifu University
- - 1982 Gifu University Agricultural Chemistry
Professional career (1):
- Doctor of Medical Science
Work history (6):
- 2008/02 - 現在 Keio University School of Medicine Professor
- 2021/10 - 2023/09 Keio University School of Medicine Vice Dean (in charge of research)
- 1999 - 2008 The University of Tokushima
- 1997 - 1999 米国ペンシルバニア大学Research Assistant Professor
- 1990 - 1997 米国ペンシルバニア大学研究員
- 1988 - 1990 日本学術振興会特別研究員
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Committee career (7):
Awards (4):
- 1989: 東燃賞
- 2000: CAN Foundation Research Award
- 1999: FRAXA Research Foundation Award
- 1998: MRDDRC Young Investigator Award
Association Membership(s) (5):
The RNA Society
, 日本分子生物学会
, 日本RNA学会
, The RNA Society of Japan
, The Moleular Biology Society of Japan
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