Ohshima Toshio

オオシマトシオ | Ohshima Toshio

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ohshima.biomed.sci.waseda.ac.jp/

Research field (2)： Neuroanatomy and physiology , Neuroscience - general

Research theme for competitive and other funds (10)：

2022 - 2025 Study on the role of CRMP2 phosphorylation in neural circuit formation and regeneration
2018 - 2023 Cross-talk between endocrine and environmental factors in neuroimmune disorders
2018 - 2021 CRMPをターゲットとした神経損傷・神経変性疾患治療戦略開発
2014 - 2017 Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
2009 - 2011 Functional analysis of Cdk5 by using conditional KO of its activating subunit p35

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Papers (125)：

Yuebing Wang, Musukha Mala Brahma, Kazuya Takahashi, Alessandra Nolia Blanco Hernandez, Koki Ichikawa, Syuntaro Minami, Yoshio Goshima, Takayuki Harada, Toshio Ohshima. Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma. Neuromolecular medicine. 2024. 26. 1. 13-13
Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, et al. Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. Frontiers in neurology. 2022. 13. 994676-994676
Musukha Mala Brahma, Kazuya Takahashi, Kazuhiko Namekata, Takayuki Harada, Yoshio Goshima, Toshio Ohshima. Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 8. 526-536
Miyuki Takahashi, Toshiyuki Takasugi, Arisa Kawakami, Ran Wei, Kanae Ando, Toshio Ohshima, Shin-ichi Hisanaga. Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice. Neurochemical Research. 2022. 47. 9. 2773-2779
Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, et al. An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities. Science advances. 2022. 8. 23. eabm6155

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MISC (5)：

M. Takahashi, M. Ishida, T. Saito, H. Kobayashi, A. Kawakami, T. Takasugi, T. Ohshima, S. Hisanaga. Effect of valproic acid on Cdk5 activity and mouse behavior. JOURNAL OF NEUROCHEMISTRY. 2014. 130. 37-37
Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Toshio Ohshima, Yoshio Goshima. Sema3A regulates apical dendritic growth of hippocamal CA1 pyramidal neurons. NEUROSCIENCE RESEARCH. 2009. 65. S46-S46
Yoko Ito, Hideomi Tanaka, Hitoshi Okamoto, Toshio Ohshima. Expression profiling of neural stem cell markers in dividing cells of the adult zebrafish optic tectum. NEUROSCIENCE RESEARCH. 2008. 61. S169-S169
Naoya Yamashita, Asa Morita, Yutaka Uchida, Toshio Ohshima, Fumio Nakamura, Jerome Honnorat, Pappachan Kolattukudy, Yoshio Goshima. CRMP1 regulates spine maturation through mediating Semaphorin3A signaling in vivo. NEUROSCIENCE RESEARCH. 2007. 58. S204-S204
Yutaka Uchida, Toshio Ohshima, Naoya Yamashita, Fumio Nakamura, Papachan Kolattukudy, Jerome Honnorat, Yoshio Goshima. Phosphorylation of CRMP2 at S522 is required for proper dendritic patterning of layer V cortical neurons in vivo. NEUROSCIENCE RESEARCH. 2007. 58. S203-S203

Books (1)：

Cyclin Dependent Kinase5
Spriger 2008 ISBN:9780387788869

Lectures and oral presentations (1)：

Requirement of Cdk5 for proper cerebellar development and function
(2nd international symposium on Cdk5 Tokyo 2009)

Professional career (1)：

MD, PhD (Yamanashi Medical University)

Awards (1)：

2001 - 日本神経化学会奨励賞

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