Research keywords (4)：
病態医科学
, biochemistry
, 免疫学
, Immunology
Research theme for competitive and other funds (61)：
2021 - 2026 Brain inflammation and repair mechanism by adaptive immunity
2019 - 2022 Enhancement of anti-tumor response by augmentation by cytokine signaling.
2017 - 2022 Immune systems involved in the resolution of inflammation and tissue repair
2020 - 2021 Development of T cell reprogramming method by metabolic and epigenomic modification
2016 - 2019 Generation and Application of Stem Cell Memory T Cells
2016 - 2018 The role of Nr4a3 on intestinal homeostasis
2013 - 2018 Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairing
2014 - 2017 Differentiation and function of Foxp3-negative IL-10-producing regulatory T cells on mucosal bacterial infection
2014 - 2016 Direct reprogramming of human fibroblasts into hematopoietic cells mainly using ETV2
2013 - 2016 The search and functional analysis of the natural compound promoting the differentiation of regulatory T cells.
2013 - 2016 Development of simulation method of behaviors in the body based on signal transduction pathway
2013 - 2015 Systemic Biology of T cell differentiation
2011 - 2015 Commensal bacteria suppresses food allergy by inhibiting ILC2 cytokine production through the induction of IL-17 producing cells
2011 - 2012 Systembiology of T-cell differentiation
2010 - 2012 Regulatory Mechanisms of the Balance between Inflammation andAnti-inflammation by Cutokines
2008 - 2010 Development of simulation method of cell group population based on signal transduction pathway's behaviors
2006 - 2009 Molecular Mechanism of Regulation of the Cytokine Signal and Immunity
2005 - 2009 Abnormal differentiation of tumor cells and tyrosine kinase regulation
2008 - 2008 ヘルパーT細胞分化のシミュレーション
2001 - 2005 サイトカインのシグナル制御機構とその破綻
2000 - 2004 Mechanism of Regulation of Tyrosine Kinase Signaling
2001 - 2002 炎症性疾患におけるCIS/JAB遺伝子群の意義の解明
2000 - 2002 サイトカイン、接着分子の情報伝達制御
2001 - 2001 JAK/STATシグナル伝達系アンタゴニストの検索法の開発と応用
2001 - 2001 免疫系におけるCISファミリー遺伝子群の機能解析
2000 - 2001 Suppressopm of growth of leukemia cells by a tyrosine kinase inhibitor JAB
1999 - 2001 サイトカインシグナル伝達経路の可視化
1998 - 2001 造血細胞のシグナル伝達
1999 - 2000 Physiological function and Molecular mechanism of regulation by the CIS/JAB family members
1999 - 1999 赤血球産生を制御するシグナル伝達分子の探索と機能解析
1998 - 1999 Molecular mechanism of negative regulation of JAK/STAT pathway by the CIS/JAB family members
1998 - 1999 Screening of signal transducing molecules by using transient expression
1998 - 1999 CISファミリーによるJAKシグナルの制御機構と生理機能
1997 - 1999 Growth and differentiation signals of the erythropoietin receptor
1996 - 1999 情報伝達とリンパ球の機能分化
1998 - 1998 赤血球分化に関与するシグナル伝達分子の探索と機能解析
1997 - 1998 Physiological Function and Signal Transduction Mechanism of the STAT5-target genes
1997 - 1997 赤血球分化に関する情報伝達分子の探索と機能解析
1997 - 1997 サイクリンE-p21特異的なユビキチンリガーゼの解析
1997 - 1997 c-kitおよびJAKキナーゼの新規基質の単離と機能解析
1997 - 1997 造血細胞の増殖と分化を制御するシグナル伝達分子群の解析
1996 - 1996 サイトカイン受容体の情報伝達機構とその標的遺伝子の解析
1996 - 1996 免疫系におけるJAKキナーゼを介した情報伝達経路と標的遺伝子
1996 - 1996 SH2ドメインを有する新規情報伝達分子CISの機能解析
1996 - 1996 造血細胞の増殖と分化を制御するシグナル伝達分子群の解析
1995 - 1996 Growth and Differentiation through the Cytokine Receptors
1995 - 1995 SH2ドメインを有する新規情報伝達分子CISの機能解析
1995 - 1995 造血幹細胞の増殖と分化を制御するシグナル伝達分子群の解析
1994 - 1995 The mechanism of regulation of P-glycoprotein (Analysis of multidrug-resistant mutants that do not express P-glycoprotein)
1994 - 1994 エリスロポエチン受容体の情報伝達機構と細胞増殖およびがん化との関連
1994 - 1994 造血幹細胞の増殖を制御するシグナル伝達分子群の解析
1993 - 1994 Structure and Signal Transduction of the Erythropoietin Receptor
1993 - 1994 The mechanism of angiogenesis by PD-ECGF
1993 - 1993 チミジンホスホリラーゼ活性と血管新生の関連性について
1993 - 1993 エリスロポエチン受容体の情報伝達機構と細胞増殖およびがん化との関連
1993 - 1993 サイトカイン受容体の構造と情報伝達機構の分子機序に関する共同研究
1992 - 1992 シスプラチン耐性機構の解析と耐性克服方法の開発
1988 - 1988 多剤耐性遺伝子の発現と耐性腫瘍出現の関連性、およびP-糖蛋白質の機能の解析
1987 - 1988 上皮生長因子とトランスフェリンの細胞内取り込み過程欠損変異株の分離と解析
サイトカインのシグナル伝達制御
Regulation of Cytokine Signaling
Show all
Papers (568)：
Daisuke Aki, Taeko Hayakawa, Tanakorn Srirat, Shigeyuki Shichino, Minako Ito, Shin-Ichiroh Saitoh, Setsuko Mise-Omata, Akihiko Yoshimura. The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models. The Journal of clinical investigation. 2024
Kensuke Nakagawara, Makoto Ando, Tanakorn Srirat, Setsuko Mise-Omata, Taeko Hayakawa, Minako Ito, Koichi Fukunaga, Akihiko Yoshimura. NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors. Journal for immunotherapy of cancer. 2024. 12. 8
Mana Iizuka-Koga, Minako Ito, Noriko Yumoto, Setsuko Mise-Omata, Taeko Hayakawa, Kyoko Komai, Shunsuke Chikuma, Satoru Takahashi, Isao Matsumoto, Takayuki Sumida, et al. Reconstruction of Sjögren's syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody. Clinical immunology (Orlando, Fla.). 2024. 264. 110258-110258
Shuya Miyazaki, Nobuyuki Shimizu, Hiroaki Miyahara, Hitoshi Teranishi, Ryohei Umeda, Shinji Yano, Tatsuo Shimada, Hiroshi Shiraishi, Kosaku Komiya, Akira Katoh, et al. DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 2024
Tanakorn Srirat, Taeko Hayakawa, Setsuko Mise-Omata, Kensuke Nakagawara, Makoto Ando, Shigeyuki Shichino, Minako Ito, Akihiko Yoshimura. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment. Cell reports. 2024. 43. 3. 113898-113898
Takashi Shchita, Akihiko Yoshimura. The mechanism underlying the resolution of sterile inflammation through scavenger receptor. Seikagaku. 2018. 90. 1. 99-102
Hiroko Nakatsukasa, Akihiko Yoshimura. TET2 and TET3 regulate helper T cell differentiation in the periphery. CYTOKINE. 2017. 100. 172-172
2022/09 - 2022 ICIS-Pfizer Award for Excellence in Cytokine & Interferon Research Discovery of Negative Regulators of Cytokine Signaling and Transcription in Immune Tolerance“
2021/11 - 日本国政府 紫綬褒章
2021/03 - 上原記念生命科学振興財団 上原賞
1997 - 日本生化学奨励賞
Association Membership(s) (5)：
THE JAPANESE CANCER ASSOCIATION
, 日本炎症再生学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, 日本生化学会
