2018 - 2021 Anti-obesity effect by re-programming glycolysis and lipogenesis
2017 - 2020 Mechanism on efffect of anti-obesity by chrebp deficiency
2017 - 2020 The role of iron in aging
2016 - 2019 Elucidation of ALS pathophysiology using monoclonal antibodies that specifically recognizes SOD1 aggregates
2015 - 2018 Elucidation of the mechanism of onset of fatty liver / NASH caused by oxidative stress
2015 - 2018 Detection of nitrated molecules involved in sugar metabolism
2013 - 2016 The effect of ChREBP activation in the development of metabolic syndrome
2012 - 2015 Effects of oxidative stress on brain function
2011 - 2013 Structure analysis of mutant SOD1 and ALS immunotherapy using new monoclonal antibodies
2010 - 2012 Obesity and oxidative stress: involvement of SOD in the physiology of metabolic syndrome and atherosclerosis
2008 - 2010 The compensatory mechanism against oxidative stress in kidney dysfunction
2007 - 2009 The role of oxidized SOD1 on ALS using the new antibody against oxidized SOD1 (anti-C111ox-SOD1)
2007 - 2008 Anti-oxidative effect of EC-SOD and prevention of atherosclerosis in lifestyle-related diseases.
2006 - 2007 Nuclear translocation of antioxidant enzymes and ROS metabolism
2005 - 2006 Conformational change in FALS-linked mutant Cu/Zn-SOD analyzed by monoclonal antibodies
2003 - 2005 Nuclear translocation of antioxidant enzymes and ROS metabolism
2001 - 家族性性ALSを引き起こすCu/Zn-SODの構造変化に関する研究
金属代謝における酸化ストレスの関与
Oxidatiove stress and metal metabolism
Conformational study of muant Cu/Zn-SOD
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Papers (49)：
Yoshiyuki Asai, Kyoka Yano, Tomoyuki Higashino, Daisaku Yoshihara, Haruhiko Sakiyama, Hironobu Eguchi, Kazuaki Fukushima, Keiichiro Suzuki, Noriko Fujiwara. The Ile35 Residue of the ALS-Associated Mutant SOD1 Plays a Crucial Role in the Intracellular Aggregation of the Molecule. Molecular neurobiology. 2024
Sumio Minamiyama, Madoka Sakai, Yuko Yamaguchi, Makiko Kusui, Hideki Wada, Ryota Hikiami, Yoshitaka Tamaki, Megumi Asada-Utsugi, Akemi Shodai, Akiko Makino, et al. Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model. Molecular Therapy - Methods & Clinical Development. 2023. 28. 312-329
Daisaku Yoshihara, Noriko Fujiwara, Hironobu Eguchi, Haruhiko Sakiyama, Keiichiro Suzuki. Iron deficiency aggravates DMNQ-induced cytotoxicity via redox cycling in kidney-derived cells. Free radical research. 2022. 1-11
Haruhiko Sakiyama, Lan Li, Minako Inoue, Hironobu Eguchi, Daisaku Yoshihara, Noriko Fujiwara, Keiichiro Suzuki. ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression. Journal of clinical biochemistry and nutrition. 2022. 71. 3. 221-228
Haruhiko Sakiyama, Lan Li, Sachi Kuwahara-Otani, Tsutomu Nakagawa, Hironobu Eguchi, Daisaku Yoshihara, Masakazu Shinohara, Noriko Fujiwara, Keiichiro Suzuki. A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue. Molecular and cellular biochemistry. 2021. 476. 10. 3577-3590
