Rchr
J-GLOBAL ID：200901047924690644
Update date: Oct. 25, 2024
Nakamura Ryosuke
ナカムラ リョウスケ | Nakamura Ryosuke
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
Homepage URL (1)：
http://www.nihs.go.jp/mss/
Research field (6)：
Clinical pharmacy
, Gastroenterology
, Dermatology
, Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (13)：
Drug-induced Liver Injury
, HLA
, Severe Cutaneous Adverse Reactions
, Serious Adverse Drug Reactions
, Genome-wide Association Study
, イムノグロブリンE
, マスト細胞
, IgE Crosslinking-induced Luciferase Expression test
, アレルギー
, mast cells
, IgE
, EXiLE
, allergy
Research theme for competitive and other funds (26)：
- 2023 - 2027 IgE架橋を近接ライゲーションアッセイで捉える高感度セルフリーアレルギー試験の開発
- 2023 - 2027 アジア地域における国際共同治験の推進に向けた環境整備に関する研究
- 2023 - 2026 IgEの架橋活性を指標とする新規セルフリーアレルギー試験法の開発
- 2022 - 2025 Mechanistic study of sulfa drug-induced severe cutaneous adverse reactions by focusing on HLA-A*11:01
- 2021 - 2025 Scientific research of the onset mechanism of drug-induced idiosyncratic toxicity to avoid serious side effects
- 2022 - 2025 重篤副作用患者由来iPS細胞バンクの構築に向けたフィージビリティ研究
- 2022 - 2023 東南アジア地域で国際共同治験を計画する際の留意事項に関する研究
- 2017 - 2020 Influence of environmental microplastic to IgE crosslinking ability of food allergens
- 2016 - 2019 The allergen affinity-based molecular editing of the high-affinity receptor for IgE on allergic responses.
- 2016 - 2019 Study of the mechanism and therapeutic biomarkers for sublingual immunotherapy by using the EXiLE method
- 2015 - 2019 Construction of novel MHC-class II based strategy and evaluation method for drug-induced myopathy.
- 2015 - 2018 Development of the simple and rapid detection method for food allergen
- 2014 - 2018 Development of a diagnostic method for severe cutaneous adverse reactions by genom biomarkers and their pathophysiological relevanceic
- 2013 - 2016 Development of comprehensive allergenic epitope exploring method by means of EXiLE and mass spectrometry
- 2012 - 2015 Analysis of the allergenicity change of structurally modified food allergens and development of highly sensitive detection method
- 2011 - 2014 Mechanistic analysis and prediction of infusion reactions
- 2010 - 2012 Development of the attogram protein detection system using cultured cell lines and chimeric molecules
- 2009 - 2011 Studies for the mechanism of the mucosal immunity of mice and the application for desensitization of environmental allergens
- 2007 - 2009 Development of negative signal-inducing anti-allergic IgE
- 2006 - 2008 Development of high sensitive analyzing methods for linear- and conformational-epitope of environmental allergens
- 2004 - 2005 抑制制御分子発現制御システムによる新規マスト細胞活性化シグナル伝達分子の探索
- 2003 - 2005 Study of the effect of environmental chemicals on the high-affinity IgG receptor-mediated signal transudation of mest cells.
- アレルゲンデータベースADFS(Allergen Database for Food Safety)の構築
- 新規培養細胞株を用いた高感度・高信頼性アレルギー試験法(EXiLE法)の開発
- ADFS - Allergen Database for Food Safety -
- EXiLE - Cell-based novel allergy test -
Show all
Papers (154)：
-
Haruyo Akiyama, Chisato Kurisaka, Kenichi Kumasaka, Ryosuke Nakamura. Novel IgE crosslinking-induced luciferase expression method using human-rat chimeric IgE receptor-carrying mast cells. Journal of immunological methods. 2024. 529. 113682-113682
-
Koya Fukunaga, Eri Tsukagoshi, Ryosuke Nakamura, Kayoko Matsunaga, Takeshi Ozeki, Hideaki Watanabe, Akito Hasegawa, Natsumi Hama, Maiko Kurata, Yoshiko Mizukawa, et al. Association of HLA-A∗11:01, HLA-B∗39:01, and HLA-B∗56:03 with salazosulfapyridine-induced cutaneous adverse drug reactions. The Journal of Allergy and Clinical Immunology: In Practice. 2024. 12. 5. 1355-1358
-
Eri Tsukagoshi, Ryosuke Nakamura, Nahoko Kaniwa, Kimie Sai, Ruri Kikura-Hanajiri, Kayoko Matsunaga, Riichiro Abe, Hideo Asada, Yoshiro Saito. Clinical Profiles of Japanese Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Collected by a Nationwide System from 2006 to 2023. Biological & pharmaceutical bulletin. 2024. 47. 1. 88-97
-
Koya Fukunaga, Eri Tsukagoshi, Maiko Kurata, Yoshiko Mizukawa, Hiroyuki Niihara, Eishin Morita, Yuko Watanabe, Yukie Yamaguchi, Hideaki Watanabe, Saeko Nakajima, et al. Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions. The Journal of investigative dermatology. 2023. 144. 4. 908-911
-
Eri Tsukagoshi, Ryosuke Nakamura, Yoichi Tanaka, Keiko Maekawa, Masahiro Hiratsuka, Hideo Asada, Yoshiro Saito. Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in the Japanese population. Drug Metabolism and Pharmacokinetics. 2023. 49. 100495-100495
ｍore...
MISC (31)：
-
中村亮介, 荒川憲昭, 田中庸一, 内山奈穂子, 関根章博, 真下陽一, 辻恵二, 加川建弘, 佐藤賢, 渡邊真彰, et al. 日本人の漢方薬による薬物性肝障害発症と関連するHLA-B*35:01. アレルギー. 2023. 72. 6/7
-
岡山 吉道, 豊島 翔太, 伊崎 聡, 葉山 惟大, 中村 亮介, 同大学医学部免疫・アレルギー学プロジェクトチーム. アレルギー・免疫領域の研究・診療に活かせる技術の進歩 抗IgE自己抗体の検出. アレルギー. 2021. 70. 6-7. 637-637
-
岡山 吉道, 豊島 翔太, 伊崎 聡志, 遠藤 嵩大, 柏倉 淳一, 布村 聡, 中村 亮介, 秋山 晴代, 鐘ヶ江 加寿子, 高橋 恭子, et al. 自己免疫・アレルギー疾患の難治化におけるマスト細胞の役割の解明. 日本大学医学部総合医学研究所紀要. 2019. 7. 1-4
-
岡山 吉道, 豊島 翔太, 伊崎 聡志, 遠藤 嵩大, 柏倉 淳一, 布村 聡, 中村 亮介, 秋山 晴代, 鐘ヶ江 加寿子, 高橋 恭子, et al. 自己免疫・アレルギー疾患の難治化におけるマスト細胞の役割の解明. 日本大学医学部総合医学研究所紀要. 2019. 7. 1-4
-
秋山 晴代, 中村 亮介, 櫻井 大樹, 平野 吉彬, 根来 孝治, 岡本 美孝. 舌下免疫療法実施時における血清中中和抗体活性のin vitro評価法の開発. アレルギー. 2018. 67. 4-5. 588-588
ｍore...
Patents (6)：
-
I型アレルギーの検査方法
-
キメラFcεRIα鎖遺伝子、キメラFcεRIα鎖タンパク質、細胞、分析用キット、及び分析方法
-
重症薬疹のmiRNA診断バイオマーカー
-
重症薬疹のタンパク質診断バイオマーカー
-
びまん性肺胞障害型薬剤性間質性肺炎のmiRNA診断バイオマーカー
ｍore...
Books (3)：
-
Basophils and Mast Cells. 2nd Ed.
2020
-
食物アレルギーの現状とリスク低減化食品素材の開発 = The actual condition of food allergy and development of the risk-reducing food materials
シーエムシー出版 2015 ISBN:9784781310572
-
Basophils and Mast Cells
2014
Lectures and oral presentations (41)：
-
レギュラトリーサイエンスの萌芽研究最前線
(第12回レギュラトリーサイエンス学術大会 2022)
-
培養マスト細胞株を用いたアレルギー試験法
(第34回バイオメディカル分析科学シンポジウム 2022)
-
重症薬疹の発症と関連するHLA型とその発症機序における役割
(第1回 医薬品毒性機序研究会 2019)
-
経口免疫寛容誘導時における減感作状態のEXiLE法を用いた評価
(日本薬学会第138年会 2018)
-
Analyses of Physicochemical Interaction of a Drug with its Risk HLA Type
(3rd International Symposium of Stevens-Johnson syndrome 2018)
ｍore...
Education (2)：
- - 2000 Nagoya City University
- - 2000 Nagoya City University Graduate School, Division of Pharmaceutical Sciences Pharmacology
Professional career (1)：
- Ph.D. (Nagoya City University)
Work history (4)：
- 2024/04 - 現在 Faculty of Pharmaceutical Sciences, Teikyo University Laboratory of Pharmaceutical Bioscience
- 2021/04 - 2024/03 National Institute of Health Sciences
- 2019/04 - 2021/03 Japan Agency for Medical Research and Development
- 2000/10 - 2019/03 National Institute of Health Sciences
Committee career (4)：
- WHO International Working Group for Drug Statistics Methodology
- 環境リスク評価委員会 免疫毒性評価ワーキンググループ委員
- OECD Expert Group on Extended One-Generation Reproductive Toxicity Study
- Japanese Society of Immunotoxicology Councilor
Awards (3)：
- 2011/09 - The Japanese Society of Immunotoxicology JSIT first prize for encouragement
- 2011 - Gakujutsu-Taikaisho (The Academic Award of Japanese Society of Allergology)
- 2009 - Prize for annual convention, 16th Annual Meeting of the Japanese Society of Immunotoxicology
Association Membership(s) (5)：
Japanese Society of Allergology
, Japanese Society of Immunotoxicology
, Pharmaceutical Society of Japan
, Society for Regulatory Science of Medical Products
, The Japanese Society of Toxicology
