Research field (2)：
Pathobiochemistry
, Tumor biology
Research keywords (4)：
colorectal cancer
, Cachexia
, Metastasis
, Oncology
Research theme for competitive and other funds (22)：
2023 - 2026 Development of therapeutic strategies targeting regulatory mechanisms of colorectal cancer stem cell differentiation
2022 - 2025 Molecular mechanisms that maintain stemness in metastatic colorectal cancer
2022 - 2024 Mechanisms of the immune evasion through polarity switching of the colorectal cancer clusters
2021 - 2024 MyD88阻害によるKRAS変異大腸がんの新規治療法の開発
2021 - 2023 Development of novel strategies for overcoming drug resistance and recurrence of colorectal cancer by targeting the pathways regulating plasticity and metastasis-initiating activity of cancer stem cells.
2018 - 2021 Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasis
2017 - 2020 Interdisciplinary / international collaborative research on diagnosis and new treatment development based on the pathophysiology of desmoid type fibromatosis
2016 - 2019 Investigation of the roles of primary cilium in cancer metastasis
2014 - 2018 Formulation of a hub for metabolome analysis and development of medical basic technologies based on cancer specific metabolism
2014 - 2018 Development of cancer therapy based on the hypoxia response of cancer cells
2014 - 2017 Elucidating the mechanisms of colorectal cancer metastasis using mouse models
2013 - 2016 Development of new therapeutic strategy targeting epithelial-mesenchymal transition and sialyl lewis glycans
2012 - 2013 Development of in vivo screening systems for cancer metastasis suppressors
2011 - 2013 Role of PLEKHG1 in intestinal tumor formation
2009 - 2012 Studies on Metastasis of Digestive Cancers Using Mouse Models
2008 - 2010 Roles of novel target genes of Cdx1/2 in differentiation and transformation of intestinal epithelial cells
2005 - 2009 Epitehial-stromal interactions and molecularly targeted therapy
2007 - 2008 Studies on digestive cancer metastasis using mouse models
2005 - 2007 Molecular mechanism of involvement of homeobox transcription factors Cdx2 and Cdxl in intestinal tumors
2002 - 2006 Studies on Mechanisms of Distant Metastasis in Digestive Cancer
2000 - 2004 Epithelium-stroma interactions in carcinogenesis
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Papers (63)：
Yu Li, Teruaki Fujishita, Emi Mishiro-Sato, Yasushi Kojima, Yanqing Niu, Makoto Mark Taketo, Yuya Urano, Tomohisa Sakai, Atsushi Enomoto, Yoshihiro Nishida, et al. TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation. Cancer Science. 2023
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, et al. Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia. Nature Communications. 2023. 14. 1
Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino-Sakamoto, Naoya Sakamoto, Ken-Ichi Yasumoto, et al. L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis. Oncogene. 2023. 42. 16. 1294-1307
Kohei Amada, Naoki Hijiya, Sawa Ikarimoto, Kazuyoshi Yanagihara, Toshikatsu Hanada, Shinya Hidano, Shusaku Kurogi, Yoshiyuki Tsukamoto, Chisato Nakada, Keisuke Kinoshita, et al. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer Science. 2023. 114. 5. 2189-2202
Teruaki Fujishita, Yasushi Kojima, Rie Kajino-Sakamoto, Emi Mishiro-Sato, Yasuhiro Shimizu, Waki Hosoda, Rui Yamaguchi, Makoto Mark Taketo, Masahiro Aoki. The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells. Cancer research. 2022. 82. 22. 4179-4190
向井智美, 佐藤龍洋, 亀井保博, 加藤輝, 三城恵美, 三城恵美, 青木正博, 藪田紀一, 廣島健三, 廣島健三. Elucidation of the mechanism of tumor progression via abnormal O-GlcNAcylation of nucleoporins. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
藤下晃章, 三城恵美, 武藤誠, 青木正博, 青木正博. The role of RhoC in colorectal cancer metastasis. 日本癌学会学術総会抄録集(Web). 2023. 82nd
小島康, 三城恵美, 武藤誠, 曽我朋義, 青木正博. A hallmark of hepatic metabolic alterations in cancer cachexia. 日本癌学会学術総会抄録集(Web). 2023. 82nd
藤下晃章, 梶野リエ, 三城恵美, 武藤誠, 青木正博, 青木正博. Transposon-based screening of metastasis-related genes in a colorectal cancer mouse model. 日本癌学会学術総会抄録集(Web). 2022. 81st
1986 - 1991 Osaka University Graduate School of Medicine
1980 - 1986 Osaka University Medical School
Professional career (2)：
M.D. (Osaka University)
Ph.D. (Osaka University)
Work history (10)：
2022/01 - 現在 Aichi Cancer Center, Research Institute Vice Director
2018/04 - 現在 Aichi Cancer Center Research Institute Division of Pathophysiology Chief
2010/12 - 2018/03 Aichi Cancer Center Research Institute Division of Molecular Pathology Chief
2008/01 - 2010/12 Kyoto University Graduate School of Medicine Department of Pharmacology Associate Professor
2003/04 - 2007/12 Kyoto University Graduate School of Medicine Department of Pharmacology Lecturer
2003/01 - 2003/03 The Scripps Research Institute Department of Molecular and Experimental Medicine Assistant Professor
2000/09 - 2003/01 The Scripps Research Institute Department of Molecular and Experimental Medicine Staff Scientist
1998/12 - 2000/09 The Scripps Research Institute Department of Molecular and Experimental Medicine Senior Research Associate
1993/06 - 1998/12 The Scripps Research Institute Department of Molecular and Experimental Medicine Research Associate
1992/12 - 1993/06 University of Southern California Department of Microbiology Research Associate
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Association Membership(s) (12)：
日本がん転移学会
, THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, 日本薬学会
, 日本薬理学会
, 日本分子生物学会
, 日本癌学会
, アメリカ癌学会
, The Pharmaceutical Society of Japan
, The Japanese Pharmacological Society
, Molecular Biology Society of Japan
, Japanese Cancer Association
, American Association for Cancer Research (AACR)
