Matsuyama Hayato

松山勇人 | Matsuyama Hayato

Affiliation and department：
Other affiliations (1)：

連合獣医学研究科准教授

Research field (10)： Pharmacology , Clinical pharmacy , Physiology , Veterinary medicine , Veterinary medicine , Cell biology , Laboratory animal science , Animals: biochemistry, physiology, behavioral science , Biophysics , Neuroscience - general

Research keywords (42)： Electrophysiology , Prostate gland , Urinary bladder , Neuromuscular transmission , Smooth muscle , Nitric oxide , Intestine , Neurotransmitter , Autonomic nerve , 蠕動運動 , 電気生理 , 一酸化窒素 , 非アドレナリン・非コリン作動性神経 , 不安定膀胱 , ミュータントマウス , グリア細胞 , 膀胱平滑筋細胞 , 電位依存性Ca電流 , 脳血管 , M3サブタイプ , 過活動膀胱 , 血流調節 , サブタイプ , 膜電位反応 , セロトニン , 消化管 , 回腸平滑筋 , 膀胱 , 脳底動脈 , 受容体サブタイプ , コリン作動性神経 , 陽イオンチャネル , 収縮反応 , ノックアウトマウス , 活動電位 , 脱分極 , ガラス微小電極法 , 収縮 , イオンチャネル , カルバコール , 膀胱平滑筋 , ムスカリン受容体

Research theme for competitive and other funds (18)：

2015 - 2018 大腸におけるATP,NOおよびSP放出神経に対するムスカリン性制御機構の解明
2015 - 2018 大腸におけるATP,NOおよびSP放出神経に対するムスカリン性制御機構の解明
2015 - 2017 大腸におけるATP,NOおよびSP放出神経に対するムスカリン性制御機構の解明
2010 - 腸管の蠕動発現メカニズムの究明:各種ノックアウトマウスを武器とした新たな展開
2008 - 2009 腸神経あるいは平滑筋細胞の興奮性を調節している新たな機能分子の探索

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Papers (42)：

Tanahashi Y, Katsurada T, Inasaki N, Uchiyama M, Sakamoto T, Yamamoto M, Matsuyama H, Komori S, Unno T. Further characterization of the synergistic activation mechanism of cationic channels by M₂ and M₃ muscarinic receptors in mouse intestinal smooth muscle cells. American journal of physiology. Cell physiology. 2019
Alom F, Matsuyama H, Nagano H, Fujikawa S, Tanahashi Y, Unno T. Involvement of transient receptor potential melastatin 4 channels in the resting membrane potential setting and cholinergic contractile responses in mouse detrusor and ileal smooth muscles. The Journal of veterinary medical science. 2019. 81. 2. 217-228
Wang B, Murakami Y, Ono M, Fujikawa S, Matsuyama H, Unno T, Naitou K, Tanahashi Y. Muscarinic suppression of ATP-sensitive K⁺ channels mediated by the M₃/G_q/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions. American journal of physiology. Gastrointestinal and liver physiology. 2018. 315. 4. G618-G630
Alom F, Miyakawa M, Matsuyama H, Nagano H, Tanahashi Y, Unno T. Possible antagonistic effects of the TRPC4 channel blocker ML204 on M₂ and M₃ muscarinic receptors in mouse ileal and detrusor smooth muscles and atrial myocardium. The Journal of veterinary medical science. 2018. 80. 9. 1407-1415
Hiroshi Nagano, Yuki Sobue, Hayato Matsuyama, Shoichiro Saito, Hiroki Sakai, Firoj Alom, Yasuyuki Tanahashi, Toshiaki Ishii, Toshihiro Unno. Muscarinic M2 receptor promotes vasopressin synthesis in mice supraoptic nuclei. The Journal of endocrinology. 2018. 237. 2. 207-216

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MISC (58)：

Yasuyuki Tanahashi, Ban Wang, Yuri Murakami, Toshihiro Unno, Hayato Matsuyama, Hiroshi Nagano, Seiichi Komori. Inhibitory effects of SKF96365 on the activities of K+ channels in mouse small intestinal smooth muscle cells. JOURNAL OF VETERINARY MEDICAL SCIENCE. 2016. 78. 2. 203-211
Yasuyuki Tanahashi, Yoshirou Ichimura, Kaori Kimura, Hayato Matsuyama, Satoshi Iino, Seiichi Komori, Toshihiro Unno. Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in the myenteric layer in mouse ileal longitudinal smooth muscles. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2014. 387. 4. 377-388
Y. Tanahashi, N. Waki, T. Unno, H. Matsuyama, S. Iino, T. Kitazawa, M. Yamada, S. Komori. Roles of M-2 and M-3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine. NEUROGASTROENTEROLOGY AND MOTILITY. 2013. 25. 10. E687-E697
Hayato Matsuyama, Yasuyuki Tanahashi, Takio Kitazawa, Masahisa Yamada, Seiichi Komori, Toshihiro Unno. Evidence for M2 and M3 Muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of Cation channels in the longitudinal muscle of mouse ileum. Journal of Pharmacological Sciences. 2013. 121. 3. 227-236
Hayato Matsuyama, Toshihiro Unno, Seiichi Komori, Tadashi Takewaki. Nitrergic Inhibition of Tachykininergic Neuro-Muscular Transmission via Cyclic GMP in the Hamster Ileum. JOURNAL OF VETERINARY MEDICAL SCIENCE. 2011. 73. 4. 453-458

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Books (5)：

学問との出会い
2016
消化器・生殖器・泌尿器系に作用する薬物. 生体内消化管運動記録法. 薬理学・毒性学実験第3版
2008
Muscarinic signal transduction in gatsrointestinal smooth muscle
2003
Mechanism of inhibitory transmission at enteric neuroeffector junctions
2003
Mechanism of inhibitory transmission at enteric neuroeffector junctions.
Recent Research Development (Research Signpost) 2003

Lectures and oral presentations (26)：

マウス結腸輪走筋のコリン作動性神経-平滑筋伝達におけるM2およびM3ムスカリン受容体サブタイプの役割.
(第160回日本獣医学会学術集会 2017)
スカリン受容体を介した胃粘膜細胞の分化・増殖制御.
(第159回日本獣医学会学術集会 2016)
The mechanisms of M3 muscarinic suppression of ATP sensitive K+ (KATP) channels in mouse small intestinal smooth muscle cells.
(第88回日本薬理学 2015)
マウス結腸輪走筋におけるコリン作動性神経-平滑筋間の情報伝達を仲介するムスカリン受容体サブタイプ.
(第157回日本獣医学会学術集会 2014)
M2ムスカリン受容体サブタイプを介したバゾプレッシンの分泌調節機構.
(第157回日本獣医学会学術集会 2014)

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Education (3)：

1998 - 2002 Gifu University
- 2002 Gifu University Graduate School, Division of Veterinary Medicine Veterinary
1992 - 1998 Gifu University

Professional career (1)：

獣医学博士 (岐阜大学大学院連合獣医学研究科)

Work history (7)：

2015 - Gifu University Faculty of Applied Biological Sciences
2002/06/01 - 2004/03/31 Gifu University
2002 - - Assistant, Laboratory of Pharmacology,
2002 - - 岐阜大学農学部助手
Gifu University

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Association Membership(s) (6)：

American Association for the Advancement of Science , The Japanese Society of Vetrinary Medicine , The Japanese Pharmacological Society , 米国科学振興協会 , 日本薬理学会 , 日本獣医学会

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