Art

J-GLOBAL ID：201802279520004604   Reference number：18A1981662

Possible antagonistic effects of the TRPC4 channel blocker ML204 on M₂ and M₃ muscarinic receptors in mouse ileal and detrusor smooth muscles and atrial myocardium

マウス回腸および排尿平滑筋と心房心筋におけるM₂とM₃ムスカリン受容体に対するTRPC4チャンネル遮断薬ML204の拮抗作用の可能性

Author (6)： ALOM Firoj (Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  MIYAKAWA Masumi (Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  MATSUYAMA Hayato (Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  NAGANO Hiroshi (Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan) ,  TANAHASHI Yasuyuki (Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan) ,  UNNO Toshihiro (Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 80  Issue： 9  Page： 1407-1415(J-STAGE)  Publication year： 2018 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Ion Channels ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (5)： detrusor smooth muscle ,  ileal smooth muscle ,  4-methyl-2-(1-piperidinyl)-quinoline ,  muscarinic receptor subtypes ,  transient receptor potential canonical channel 4

JST classification (2)： Transport of cell membrane  (EF04020R) ,  Basic medicine on musculoskeletal system  (GG01020B)

Substance index (1)： Carbachol

Reference (32)：

• 1. Bolton, T. B. 1979. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev. 59: 606-718.
• 2. Bolton, T. B., Prestwich, S. A., Zholos, A. V. and Gordienko, D. V. 1999. Excitation-contraction coupling in gastrointestinal and other smooth muscles. Annu. Rev. Physiol. 61: 85-115.
• 3. Caulfield, M. P. 1993. Muscarinic receptors--characterization, coupling and function. Pharmacol. Ther. 58: 319-379.
• 4. Clapham, D. E., Runnels, L. W. and Strübing, C. 2001. The TRP ion channel family. Nat. Rev. Neurosci. 2: 387-396.
• 5. Eglen, R. M., Hegde, S. S. and Watson, N. 1996. Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev. 48: 531-565.

Terms in the title (12)： マウス ,  回腸 ,  排尿 ,  平滑筋 ,  心房 ,  心筋 ,  ムスカリン受容体 ,  TRPC4 ,  チャンネル ,  遮断薬 ,  拮抗作用 ,  可能性