Kaji Toshiyuki

カジトシユキ | Kaji Toshiyuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.rs.tus.ac.jp/kaji-lab/

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (6)：プロテオグリカンの細胞生物学 , 血管内皮細胞の機能調節 , 重金属毒性 , Cell Biology of Proteoglycans , Regulation of Vascular Endothelial Cell Functions , Heavy Metal Toxicity

Research theme for competitive and other funds (20)：

2019 - 2022 Expression, functions, and synthesis regulation of reactive sulfur species in vascular endothelial cells
1994 - 2020 血管内皮細胞および血管平滑筋細胞プロテオグリカンの代謝調節
1988 - 2020 血管内皮細胞および血管平滑筋細胞の機能調節
2015 - 2018 Mechanisms underlying endothelial metallothionein induction based on the strategy of bioorganometallics
2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices

2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression

2012 - 2015 Molecular targets and biological systems involved in the toxicity of nucleophilic organometallic compounds

2006 - 2009 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury

2004 - 2005 Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cells

1990 - 2005 細胞培養系を用いた重金属の毒性発現機序の解析

2002 - 2003 Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesis

1999 - 2000 細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節

1997 - 1998 Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytes

1996 - 1996 増殖制御因子による血管内皮細胞プロテオグリカン分子種の産生調節

1995 - 1995 血管内皮細胞プロテオグリカンの産生と放出の調節を介在する細胞内情報伝達経路

1993 - 1995 Environmental Impact Assessment and Counter-plans for Acid Rain and Snow in the Circum-pan-Japan Sea Area (Japan, Korea and China)

1992 - 1992 血管内皮細胞のグルコサミノグリカン代謝の調節因子と調節機構に関する研究

Regulation of Proteglycan Metabolism in Vascular Endothelial Cells and Vascular Smooth Muscle Cells

Regulation of the Functions of Vascular Endothelial Cells and Vascular Smooth-Muscle Cells

Analysis of the Mechanism for the Exhibition of Heavy Metal Toxicity Using Cell Culture Systems

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Papers (302)：

Eiko Yoshida, Kazuhiro Aoki, Yu Sasaki, Hinako Izuhara, Tsutomu Takahashi, Yasuyuki Fujiwara, Tomoya Fujie, Ke Du, Komyo Eto, Yo Shinoda, et al. Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons. The Journal of Toxicological Sciences. 2024. 49. 5. 241-248
Tomoya Fujie, Miyabi Kobayashi, Lihito Ikeuchi, Tsuyoshi Nakano, Kazuki Kitabatake, Yo Shinoda, Yasuyuki Fujiwara, Chika Yamamoto, Mitsutoshi Tsukimoto, Toshiyuki Kaji. Transcriptome analysis of cultured human vascular endothelial cells after γ-ray irradiation and correlation analysis with ATP, ADP, and adenosine as secondary soluble factors. The Journal of Toxicological Sciences. 2024. 49. 4. 193-208
Takato Hara, Tomoko Konishi, Shuji Yasuike, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji. Sb-Phenyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine Induces Perlecan Core Protein Synthesis in Cultured Vascular Endothelial Cells. International Journal of Molecular Sciences. 2023. 24. 4. 3656-3656
Takato Hara, Reina Kumagai, Tohru Tanaka, Tsuyoshi Nakano, Tomoya Fujie, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji. Lead suppresses perlecan expression <i>via</i> EGFR-ERK1/2-COX-2-PGI<sub>2</sub> pathway in cultured bovine vascular endothelial cells. The Journal of Toxicological Sciences. 2023. 48. 12. 655-663
Takato Hara, Shogo Matsuura, Keita Aikawa, Misaki Shirai, Mai Yoshida, Toshiyuki Kaji, Chika Yamamoto. Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells. The Journal of toxicological sciences. 2023. 48. 8. 457-467

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MISC (31)：

中村武浩, 緒方文彦, 川崎直人, 鍜冶利幸. 新規錯体医薬品の開発に向けた基礎研究:血管細胞増殖を活性化する亜鉛錯体. Fundamental Toxicological Sciences (Web). 2019. 6. Supplement
中村武浩, 吉田映子, 滝田良, 緒方文彦, 川崎直人, 内山真伸, 鍜冶利幸. 血管内皮細胞の増殖を強力に促進する亜鉛錯体. 日本薬学会年会要旨集. 2018. 138年会. 3. 249-249
中村武浩, 中村武浩, 吉田映子, 滝田良, 緒方文彦, 川崎直人, 内山真伸, 鍜冶利幸. 血管内皮細胞の増殖を強力に促進する亜鉛錯体. 日本薬学会年会要旨集(CD-ROM). 2018. 138th. 3. ROMBUNNO.26PA-pm361-249
鍜冶利幸. バイオオルガノメタリクスとは. 理大科学フォーラム. 2018. 403. 2-5
Takehiro Nakamura, Eiko Yoshida, Tomoya Fujie, Fumihiko Ogata, Chika Yamamoto, Naohito Kawasaki, Toshiyuki Kaji. Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells. Journal of Toxicological Sciences. 2017. 42. 6. 683-687

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Books (13)：

コンパス衛生薬学改訂第3版
南江堂 2020 ISBN:9784524403714
理工系の基礎薬学
丸善出版 2018 ISBN:9784621302835
トキシコロジー第3版
朝倉書店 2018 ISBN:9784254340310
衛生薬学 -健康と環境-
丸善出版 2013 ISBN:9784621086278
日本薬学会編健康と環境第2版
東京化学同人 2012 ISBN:9784807916238

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Lectures and oral presentations (276)：

鉛による血管内皮細胞の活性イオウ分子合成の誘導とその機構
(日本薬学会第141年会 2021)
血管内皮細胞においてカドミウムにより誘導されるメタロチオネインアイソフォーム
(日本薬学会第141年会 2021)
血管内皮細胞において t-PA発現を誘導するターピリジン亜鉛錯体
(日本薬学会第141年会 2021)
神経膠芽腫におけるγ線誘導のDNA損傷応答および細胞遊走亢進への細胞外アデノシンとアデノシン受容体の関与
(日本薬学会第141年会 2021)
亜ヒ酸はマクロファージ様細胞および血管平滑筋細胞による組織因子の発現を誘導する
(日本薬学会第141年会 2021)

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Works (4)：

ナトリウムスピルランの生物活性に関する共同研究
2000 -
Joint Research on the Biological Activities of Sodium Spirulan
2000 -
血管細胞のプロテオグリカンに関する共同研究
1994 -
Joint Research on Proteoglycans in Vascular cells
1994 -

Education (2)：

- 1988 Toyama Medical and Pharmaceutical University Graduate School of Pharmaceutical Sciences Pharmaceutical Sciences
- 1983 Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D (Toyama Medical and Pharmaceutical University)

Work history (17)：

2010/04 - 現在 Tokyo University of Science Faculty of Pharmaceutical Sciences Professor
2003/05 - 2010/03 Hokuriku University Faculty of Pharmaceutical Sciences
1997 - 2003 Hokuriku University Faculty of Pharmaceutical Sciences
1997 - 2003 Faculty of Pharmaceutical Sciences, Hokuriku
2003 - - Faculty of Pharmaceutical Sciences, Hokuriku

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Committee career (34)：

2019/04/01 - 2022/03/31 日本薬学会環境・衛生部会顧問
2019/04/01 - 2022/03/31 日本薬学会学会の顧問・助言委員等
2019/04/01 - 2021/03/31 公益社団法人日本薬学会学会理事等
2016/06/30 - 2020/06/30 The Japanese Society of Toxicology Editorial Committee Chair
2016/06/30 - 2020/06/30 The Japanese Society of Toxicology Editor-in-Chief, The Journal of Toxicology

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Awards (9)：

2020/06/30 - 日本毒性学会田邊賞
2018/07/19 - Pfizer Award for 2018 highly cited paper in the Journal of Toxicological Sciences)
2016/06/30 - The JSOT Award
2014/07/03 - 日本毒性学会田邊賞
2004/11 - Highlighted Paper Selected by Editor-in-Chief of “Biological & Pharmaceurical Bulletin”

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Association Membership(s) (5)：

The Pharmaceutical Society of Japan , 日本薬学会 , The Japanese Society of Toxicology , The Japanese Society of Toxicology , 公益社団法人日本薬学会

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