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J-GLOBAL ID：201702271326855974   Reference number：17A1906169

Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells

培養血管内皮細胞における銅と2,9-ジメチル-1,10-フェナントロリンの錯体形成により生じる相乗的細胞毒性

Author (8)： Nakamura Takehiro (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Nakamura Takehiro (Faculty of Pharmacy, Kindai University) ,  Yoshida Eiko (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Fujie Tomoya (Faculty of Pharmaceutical Sciences, Toho University) ,  Ogata Fumihiko (Faculty of Pharmacy, Kindai University) ,  Yamamoto Chika (Faculty of Pharmaceutical Sciences, Toho University) ,  Kawasaki Naohito (Faculty of Pharmacy, Kindai University) ,  Kaji Toshiyuki (Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 42  Issue： 6  Page： 683-687(J-STAGE)  Publication year： 2017 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cattle ,...

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Author keywords (5)： Copper complex ,  Cytotoxicity ,  Endothelial cell ,  Organic-inorganic hybrid molecule ,  Bio-organometallics

JST classification (2)： Toxicity of chemical substances in general  (GZ02010C) ,  Complexes of 9 and 10 groups  (CE01050Y)

Substance index (1)： 2,9-Dimethyl-1,10-phenanthroline

Reference (23)：

• Das, O., Chatterjee, S. and Paine, T. (2013): Functional models of α-keto acid dependent nonheme iron oxygenases: synthesis and reactivity of biomimetic iron(II) benzoylformate complexes supported by a 2,9-dimethyl-1,10-phenanthroline ligand. J. Biol. Inorg. Chem., 18, 401-410.
• Davies, G. and Loose, D.J. (1976) Reactions of copper complexes. I. Reduction of (2,9-dimethyl-1,10-phenanthroline)copper(II) complexes by thiocyanate and thiourea in aqueous perchlorate media and by thiourea in methanol. Inorg. Chem., 15, 694-700.
• Fujie, T., Hara, T. and Kaji, T. (2016a): Toxicology of organic-inorganic hybrid molecules: bio-organometallics and its toxicology. J. Toxicol. Sci., 41, SP81-SP88.
• Fujie, T., Segawa, Y., Uehara, A., Nakamura, T., Kimura, T., Yoshida, E., Yamamoto, C., Uchiyama, M., Naka, H. and Kaji, T. (2016b): Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells. J. Toxicol. Sci., 41, 217-224.
• Fujie, T., Segawa, Y., Yoshida, E., Kimura, T., Fujiwara, Y., Yamamoto, C., Satoh, M., Naka, H. and Kaji, T. (2016c): Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J. Toxicol. Sci., 41, 225-232.

Terms in the title (7)： 培養 ,  血管内皮細胞 ,  銅 ,  ジメチル ,  フェナントロリン ,  錯体形成 ,  細胞毒性