Nakanishi Makoto

2020 - 2022 Origins of senescent cells that regulate aging in vivo

2017 - 2020 Elucidation of the mechanisms underlying in vivo carcinogenesis by comprehensive analyses of cellular senescence

2016 - 2018 Genetic and biochemical analyses of mTOR related megalencephaly

2016 - 2018 Elucidation of the regulatory mechanisms of aging using senescence-accerelation mice

2014 - 2017 Tumorigenesis by aberrant maintenance DNA methylation

2010 - 2016 Control of cell fate decision in the cells differentiating to multiple pathways in a step-by-step fashion

2012 - 2015 Analysis of the nuclear receptor transcription conjugate mechanism for the hormone-resistant prostate cancer and development of the new molecular target treatment

2010 - 2015 Mechanisms underlying epigenome regulation by chromatin modifications during stem cell differentiation

2012 - 2014 Establishment of damage dose-dependent senescence inducible system and its application for understanding molecular basis underlying geriatiric diseases

2011 - 2014 Mechanism of premature senescence induction through DNA damage responses

2007 - 2011 Checkpoint analyses using anti -phosphoepitope-specific antibody

2008 - 2010 The contribution of the checkpoint genes to prostate cancer hormone resistant

2008 - 2010 Relationship of circadian rhythm with cycle control

2008 - 2010 Mechanisms of transcriptional repression in response to genome stress-role of histone H3 phosphorylation at T11-

2008 - 2009 Wee1Bを介した哺乳動物卵母細胞減数分裂機構とその異常

2008 - 2009 ヒストンH3-T11リン酸化による遺伝子発現制御とヘテロクロマチン形成の解析

2008 - 2009 チェックポイントキナーゼによる晩発型個体発ガン抑制機構の解明

2007 - 2008 SAD-Aノックアウトマウスを利用した虐待関連遺伝子の同定

2005 - 2006 Peroxisome proliferator-activated receptor-γ and growth inhibition by its ligands in prostate cancer

2005 - 2006 Molecular Mechanism of Mitotic Catastrophe

2004 - 2005 ナノテクノロジーを用いた新しい放射線治療の基礎的研究

2001 - 2005 Regulation of cell cycle checkpoints that monitor DNA damage and DNA replication block.

2004 - 2004 NF-κB活性化機構を阻害するスーパーアスピリンの合成

2002 - 2004 Analysis of meiotic DNAdamage checkpoint

2002 - 2003 The role of steroid receptor coactivator (SRC) in the development of prostate cancer

2002 - 2003 Molecular Cloning and Characterization of NAKBP, which bind to a novel IKK-Kinase, NAK

2002 - 2003 Synthesis and application of novel enone-type prostaglandin probes

2001 - 2002 分裂酵母を用いた哺乳動物細胞周期チェックポイントの再構築

2001 - 2002 Negative regulation of Chk2 expression by p53

2001 - 2002 Development of novel anti-inflammatory drugs on the basis of prostaglandin A1 structure

2001 - 2002 Elucidation of the mechanisms by which regulate DNA damage checkpoints in mammals

2000 - 2000 細胞周期チェックポイント異常による発ガンの分子機構

1999 - 2000 Elucidation of the cell cycle checkpoint mechanisms in mammalian cells

1999 - 1999 哺乳動物細胞におけるDNA複製および障害チェックポイント機構の解明

1999 - 1999 放射線発がんにおけるDNA障害チェックポイント機構の役割

1998 - 1998 プロテインキナーゼを中心とする情報ネットワークの解析

1997 - 1998 Prevention of apoptosis by p21 gene tranfer in central nervous system

1993 - 1993 老化遺伝子産物による不死化細胞のDNA合成

1990 - 1993 Regulation factors in the human energy supplying system.

1989 - 1991 Reactivation of proteins and membrane transport by the heat shock proteins from thermophilic bacteria.

発がんを抑制する分子機構に関する研究

細胞老化を制御する分子機構に関する研究

細胞周期チェックポイント制御に関する研究

NF-κBを介した細胞死制御

細胞周期制御に関する研究

Regulation of apoptosis by NF-κB

Study on Cell Cycle Regulation