Yanai Hideyuki

ヤナイヒデユキ | Yanai Hideyuki

Affiliation and department：
Homepage URL (1)： http://mol-immu.umin.jp/

Research field (1)： Immunology

Research keywords (1)： Innate Immunity, Inflammation, Infection, Cancer, Interferon

Research theme for competitive and other funds (14)：

2022 - 2025 自己炎症の誘導・遷延化に関わる自己細胞由来分子群の解明
2020 - 2024 ダメージ関連分子による炎症・免疫応答系の制御機構の解明
2018 - 2021 Role of extracellular HMGB1 in promotion of inflammation
2015 - 2020 Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
2015 - 2016 自己由来分子による炎症・免疫応答系の制御機構の解明

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Papers (74)：

Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, et al. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO journal. 2023. e114032
Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS nexus. 2023. 2. 10. pgad306
Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi, Hideyuki Yanai. Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 24. e2305245120
Asuka Inoue, Shiho Chiba, Shotaro Eto, Tadatsugu Taniguchi, Hideyuki Yanai. Potential of HMGB -inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis. Genes to Cells. 2022. 28. 3. 202-210
Reima Jinno, Atsushi Komuro, Hideyuki Yanai, Ryo Ono. Erratum: Antitumor abscopal effects in mice induced by normal tissue irradiation using pulsed streamer discharge plasma (Journal of Physics D: Applied Physics (2022) 55 (17LT01) DOI: 10.1088/1361-6463/ac4c23). Journal of Physics D: Applied Physics. 2022. 55. 29

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MISC (51)：

衞藤翔太郎, 柳井秀元. Inflammaging: Damage-associated molecular patterns (DAMPs) and inflammaging. 実験医学. 2023. 41. 19
柳井秀元, 日比野沙奈, 衞藤翔太郎, 半谷匠. Immunosuppression associated with tumor development. 月刊臨床免疫・アレルギー科. 2023. 79. 6
半谷匠, 半谷匠, 柳井秀元. Orchestration of tumor immune microenvironment by dead-cell derived molecules. 生化学. 2022. 94. 5
半谷匠, 柳井秀元. Regulation of the tumor immune microenvironment by tumor dead cell-derived molecules. 月刊臨床免疫・アレルギー科. 2022. 77. 3
神野怜磨, 小室淳史, 柳井秀元, 小野亮. Anti-tumor effect on colon cancer by irradiating plasma to normal tissues in mice. 静電気学会講演論文集. 2021. 2021

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Patents (3)：

Education (3)：

2001 - 2005 東京大学大学院医学系研究科病因・病理学専攻博士課程
1999 - 2001 Gakushuin University
1995 - 1999 Gakushuin University Faculty of Science Department of Chemistry

Professional career (1)：

博士(医学) (東京大学)

Work history (6)：

2019/04 - 現在 LSBM, RCAST Project Associate Professor
2014/07 - 2019/03 The University of Tokyo Institute of Industrial Science
2012/04 - 2014/06 The University of Tokyo Institute of Industrial Science
2007/04 - 2012/03 東京大学大学院医学系研究科助教
2006/04 - 2007/03 東京大学大学院医学系研究科助手

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Committee career (3)：

2025 - 日本癌学会評議員
2023 - 日本免疫学会評議員
2022 - 日本Cell Death学会評議員

Awards (2)：

2019/08 - 日本インターフェロンサイトカイン学会 JSICR学会奨励賞
2013 - JSI Young Investigator Award

Association Membership(s) (6)：

日本がん分子標的治療学会 , International Cytokine and Interferon Society (ICIS) , THE JAPANESE SOCIETY OF INTERFERON & CYTOKINE RESEARCH , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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