2015 - 2019 Elucidation of the exacerbation mechanisms of ischemic cardiovascular disease induced by testosterone.
2015 - 2018 An attempt to apply to new therapy the phenomenon that complete disruption of all nitric oxide synthase genes reduces cerebral infarct volume.
2015 - 2017 Elucidation of the molecular mechanism of the metabolic syndrome induced by long-term dietary nitrite and nitrate deficiency and development of the new treatment
2010 - 2014 Elucidation of anti-metabolic syndrome effects by San'oshashinto
2011 - 2013 Basic research on the role of the nitric oxide synthase system in organ connection
2006 - 2008 Effect of Kampo medicines used in the treatment of menopausal symptoms on lipid metabolism abnormality caused by loss of estrogen
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Papers (16)：
Katsuhiko Noguchi, Katsumi Kadekawa, Saori Nishijima, Mayuko Sakanashi, Shiho Okitsu-Sakurayama, Sayomi Higa-Nakamine, Hideyuki Yamamoto, Kimio Sugaya. Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat. Cannabis and cannabinoid research. 2022. 7. 2. 179-187
Yuki Kitamura, Mayuko Sakanashi, Azuki Ozawa, Yuri Saeki, Ayano Nakamura, Yuiho Hara, Ken-Ichi Saeki, Sakae Arimoto-Kobayashi. Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice. Biochemical and biophysical research communications. 2021. 555. 154-159
Hideki Mizutani, Chiaki Shiga, Masanori Imai, Kenji Ikemura, Yuki Kitamura, Kinya Ohta, Daisuke Miyazawa, Mayuko Sakanashi, Tomoko Tahira, Tohru Maeda, et al. Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II). Anticancer research. 2020. 40. 10. 5399-5404
Katsuhiko Noguchi, Kimio Sugaya, Saori Nishijima, Mayuko Sakanashi, Katsumi Kadekawa, Katsuhiro Ashitomi, Shiho Okitsu, Hideyuki Yamamoto. Evaluation of a rat model of functional urinary bladder outlet obstruction produced by chronic inhibition of nitric oxide synthase. Life sciences. 2019. 234. 116772-116772
Takaaki Ogoshi, Masato Tsutsui, Takashi Kido, Mayuko Sakanashi, Keisuke Naito, Keishi Oda, Hiroshi Ishimoto, Sohsuke Yamada, Ke-Yong Wang, Yumiko Toyohira, et al. Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice. American journal of respiratory and critical care medicine. 2018. 198. 2. 232-244
Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Junko Nakasone, Kumiko Arakaki, Makiko Sakanashi, Haruaki Kubota, Masato Tsutsui. Long-term oral administration of San'oshashinto improves vascular endothelial dysfunction and hypercholesterolemia in high fat diet-fed rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 280P-280P
Mayuko Sakanashi, Makiko Sakanashi, Katsuhiko Noguchi, Toshihiro Matsuzaki, Junko Nakasone, Matao Sakanashi. Effects of San'oshashinto on ischemia/reperfusion-induced cardiac dysfunction and serum lipid level in ovariectomized rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 228P-228P
Katsuhiko Noguchi, Toshihiro Matsuzaki, Naobumi Hamadate, Mayuko Sakanashi, Makiko Sakanashi, Junko Nakasone, Matao Sakanashi. Effect of sepiapterin in combination with methotrexate on endothelium-dependent relaxation of rat isolated aorta. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 232P-232P
