Art

J-GLOBAL ID：200902239442128540   Reference number：08A0524384

Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats

麻酔下のラットにおける内皮機能に対する内因的なテトラヒドロビオプテリンの減少した濃度の効果

Author (6)： HAMADATE Naobumi (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN) ,  NOGUCHI Katsuhiko (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN) ,  SAKANASHI Mayuko (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN) ,  MATSUZAKI Toshihiro (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN) ,  NAKASONE Junko (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN) ,  SAKANASHI Matao (Dep. of Pharmacology, School of Medicine, Fac. of Medicine, Univ. of the Ryukyus, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 107  Issue： 1  Page： 49-56 (J-STAGE)  Publication year： 2008 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Anesthesia ,...
Semi thesaurus term： enzyme inhibitor ,...

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JST classification (1)： Adrenal hormones  (EB08040D)

Substance index (3)： Tetrahydrobiopterin ,  2,4-Diaminopyrimidin-6-ol ,  Acetylcholine

Reference (27)：

• LI, H. Nitric oxide in the pathogenesis of vascular disease. J Pathol. 2000, 190, 244-254
• CHANNON, KM. Tetrahydrobiopterin : regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc Med. 2004, 14, 323-327
• ALP, NJ. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest. 2003, 112, 725-735
• BITAR, MS. Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. Eur J Pharmacol. 2005, 511, 53-64
• LANDMESSER, U. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest. 2003, 111, 1201-1209

Terms in the title (4)： 麻酔 ,  ラット ,  内皮 ,  テトラヒドロビオプテリン