Rchr
J-GLOBAL ID：200901075045632154
Update date: Sep. 03, 2024
Kirihata Mitsunori
キリハタ ミツノリ | Kirihata Mitsunori
Affiliation and department：
Homepage URL (1)：
https://www.omu.ac.jp/orp/bnct/
Research field (4)：
Clinical pharmacy
, Pharmaceuticals - chemistry and drug development
, Bioorganic chemistry
, Molecular biochemistry
Research keywords (4)：
化学生物学
, 生物有機化学
, Chemical biology
, Bioorganic Chemistry
Research theme for competitive and other funds (24)：
- 2024 - 2027 Development of a Novel Treatment Method Using Boron Radioisotope Compounds Targeting Brain and Spinal Cord Tumors
- 2022 - 2025 Developing of radiolabeling method and Investigation of in vivo pharmacokinetics of BSH using in BNCT
- 2019 - 2022 Clinical application of boron-conjugated adenovirus vector for neutron capture therapy
- 2016 - 2020 Development of boron neutron capture therapy (BNCT) technology for targeting cancer cells
- 2017 - 2019 Usefulness of a super selective arterial infusion therapy of a novel boronated porphyrin for BNCT and PDT
- 2014 - 2018 Development of targeting adenovirus vector as boron carrier for boron neutron capture therapy
- 2014 - 2017 Synthesis and evaluation of BSH-containing kojic acid (KA-BSH) as a novel agent for boron neutron capture therapy
- 2011 - 2014 Tumor-selective high LET and high RBE particles can overcome the radiation-resistant glioma stem cells
- 2010 - 2012 Development of a new method to analyzethe micro-distribution of 10B in tissues and its application to BNCT research
- 1992 - 2010 非タンパク性アミノ酸の合成
- 2005 - 2009 Basic study on cancer cell selective radiotherapy by particle beam
- 2007 - 2008 Development of boron neutron capture therapy for the standard treatment of malignant brain tumors
- 2004 - 2005 Boron neutron capture therapy on malignant brain tumors.
- 2000 - 2004 X線低感受性腫瘍に対する中性子捕捉療法の基礎研究
- 2000 - 2001 Development of New Methodologies for the efficient synthesis of biologically active compounds
- 1998 - 2000 Preclinical study of neutron capture therapy for malignant brain tumors using newly developed BPA delivatives
- 1990 - 1992 流通過程における花卉の生理特性と品質保持,ならびに流通システムの確立に関する研究
- 中性子捕捉療法に用いるホウ素化合抑の分子設計と合成
- ハイブリッドプロセスによる生理活性物質の合成
- 生理活性アミノ酸およびペプタイドの合成
- Design and synthesis of boron containing compounds for Boron-neutron capture therapy
- Synthesis of bioactive compounds by hybrids process
- Synthesis of bioactive amino acids and peptides
- Synthesis of non-proteinous amino acids
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Papers (127)：
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Riku Kawasaki, Ayano Oshige, Nanami Kono, Keita Yamana, Hidetoshi Hirano, Yamato Miura, Ryuji Yorioka, Kaori Bando, Anri Tabata, Naoki Yasukawa, et al. Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy. ACS applied materials & interfaces. 2024
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Shin-Ichiro Masunaga, Yu Sanada, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Mitsunori Kirihata, Koji Ono. The impact of TP53 status of tumor cells including the type and the concentration of administered 10B delivery agents on compound biological effectiveness in boron neutron capture therapy. Journal of radiation research. 2023. 64. 2. 399-411
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Hideki Kashiwagi, Yoshihide Hattori, Shinji Kawabata, Ryo Kayama, Kohei Yoshimura, Yusuke Fukuo, Takuya Kanemitsu, Hiroyuki Shiba, Ryo Hiramatsu, Toshihiro Takami, et al. Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model. Cancers. 2023. 15. 4
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Shiori Hirase, Ayako Aoki, Yoshihide Hattori, Kenta Morimoto, Kosuke Noguchi, Ikuo Fujii, Tomoka Takatani-Nakase, Shiroh Futaki, Mitsunori Kirihata, Ikuhiko Nakase. Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy. Molecular pharmaceutics. 2022. 19. 4. 1135-1145
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Yoshihide Hattori, Miki Ishimura, Youichirou Ohta, Hiroshi Takenaka, Shinji Kawabata, Mitsunori Kirihata. Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy. ACS Medicinal Chemistry Letters. 2021
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MISC (262)：
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中瀬生彦, 服部能英, 切畑光統. 機能性ペプチドを用いたBNCTホウ素化合物の細胞内導入技術. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
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服部能英, 石村美紀, 石村美紀, 大田洋一郎, 大田洋一郎, 竹中宏誌, 竹中宏誌, 中瀬生彦, 切畑光統. Synthesis of Bifuctional Dodecaborate for the development of Theranostic Type Boron Carrier. 日本薬学会年会要旨集(Web). 2023. 143rd
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服部能英, 切畑光統. Dynamics of BPA, a tumor targeted boron amino acid for boron neutron capture therapy (BNCT). Dojin News. 2022. 182
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平瀬詩織, 青木絢子, 野口公輔, 森本健太, 服部能英, 切畑光統, 中瀬生彦. ホウ素中性子捕捉療法におけるエクソソームを用いたホウ素薬剤の細胞内導入. 日本DDS学会学術集会プログラム予稿集. 2021. 37th
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平瀬詩織, 青木絢子, 堺有里子, 石村美紀, 野口公輔, 森本健太, 中瀬朋夏, 中瀬朋夏, 服部能英, 切畑光統, et al. Functional peptide-modified boron compounds for boron neutron capture therapy. 日本薬学会年会要旨集(Web). 2021. 141st
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Patents (15)：
Books (11)：
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Research and Development in Neutron Capture Therapy
Monduzzi Editore 2002
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Research and Development in Neutron Capture Therapy
Monduzzi Editore 2002
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Organohalogen Compounds, Vol.54
Catholic Univesity of Daegu. 2001
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Advances in Chitine Science Vol. IV
Universitat Potsdam 1999
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Peptide Science
The Japanese Peptide Society Kyoto 1999
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Lectures and oral presentations (56)：
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酵素免疫抗体法(ELIZA)による血中10B-ホウ素化合物の簡易分析法の開発
(第5回日本中性子捕捉療法学会学術大会 2008)
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キャピラリー電気泳動(CAPI)法によるBSHの純度及び濃度分析
(第5回日本中性子捕捉療法学会学術大会 2008)
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側鎖にBSHを導入した光学活性なL-α-アミノ酸類の合成
(第5回日本中性子捕捉療法学会学術大会 2008)
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再発頭頸部悪性腫瘍に対する硼素中性子捕捉療法の有用性
(第5回日本中性子捕捉療法学会学術大会 2008)
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硼素中性子捕捉療法は再発悪性グリオーマの生命予後改善に貢献しているか?
(第5回日本中性子捕捉療法学会学術大会 2008)
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Works (9)：
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文部科学省・原子力基礎基盤戦略イニシアティブ
2008 -
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先端技術を活用した農林水産研究高度化事業、畜産排水の色度とCOD成分低減のための低コスト処理技術の開発
2004 - 2005
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実用化のための可能性試験課題、ホウ素-ガン中性子捕捉療法(BNCT)に実用化される高純度ホウ素化合物L-BPAの大量合成の開発
2004 -
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地域新生コンソーシアム研究開発事業、がん中性子捕捉療法用に最適化デザインされたナノデバイスの開発
2002 -
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新規ボロン化合物製剤を用いた癌中性子捕捉療法適応拡大の研究調査
2000 -
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Professional career (1)：
- Doctor of Philosophy (Osaka Prefecture University)
Committee career (1)：
Association Membership(s) (6)：
日本中性子捕捉療法学会
, 日本ペプチド学会
, International Society of Neutron Capture Therapy
, 日本生物工学会
, 日本農薬学会
, 日本農芸化学会
