Rchr
J-GLOBAL ID:200901075117576963   Update date: Sep. 14, 2024

Takagi Junichi

タカギ ジュンイチ | Takagi Junichi
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.protein.osaka-u.ac.jp/rcsfp/synthesis/
Research field  (1): Structural biochemistry
Research keywords  (6): protein engineering ,  X線結晶構造解析 ,  蛋白質化学 ,  構造生物学 ,  signal transduction ,  structural biology
Research theme for competitive and other funds  (36):
  • 2020 - 2024 Novel design of AAV capsid by LassoGraft Technology
  • 2020 - 2023 Structural elucidation of Wnt signaling mechanism using unique chemical tools
  • 2018 - 2020 Re-engineering of AAV particle by "peptide insertion" method
  • 2017 - 2020 Structural mechanism of the Wnt-receptor interaction
  • 2012 - 2017 Analysis and Synthesis of Multidimensional Immune Organ Network
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Papers (235):
  • Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai. A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. iScience. 2024. 27. 8. 110426-110426
  • Giulia Franzolin, Serena Brundu, Carina Florina Cojocaru, Aurora Curatolo, Matteo Ponzo, Roberta Mastrantonio, Emiko Mihara, Atsushi Kumanogoh, Hiroaki Suga, Junichi Takagi, et al. PlexinB1 inactivation reprograms immune cells in the tumor microenvironment, inhibiting breast cancer growth and metastatic dissemination. Cancer immunology research. 2024
  • Takao Arimori, Emiko Mihara, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Junichi Takagi, Yukinari Kato. Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies. Structure. 2024
  • Zhihai Hua, Ryoma Watanabe, Taku Fukunaga, Yojiro Matsui, Mayu Matsuoka, Shoya Yamaguchi, Shun-Ya Tanabe, Miyu Yamamoto, Keiko Tamura-Kawakami, Junichi Takagi, et al. C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility. Biochemical and biophysical research communications. 2024. 696. 149504-149504
  • Noriko Arase, Yusuke Sasaoka, Jun Narita, Eiji Kiyohara, Kazuhisa Hashimoto, Shinichiro Shinzaki, Satoshi Nojima, Junichi Takagi, Manabu Fujimoto. Anti-α6β4 integrin autoantibodies inhibit the binding of laminins to α6β4 integrin in patients with pemphigoid and affect the gastrointestinal tract. Journal of the European Academy of Dermatology and Venereology : JEADV. 2024. 38. 2. 404-412
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MISC (111):
Patents (11):
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Books (11):
  • 構造生物学が明らかにする細胞膜を介したシグナリング機構/実験医学増刊号 シグナリング研究2015
    羊土社 2015
  • 融合発展する構造生物学とケミカルバイオロジーの最前線
    共立出版 2010 ISBN:9784320057050
  • 融合発展する構造生物学とケミカルバイオロジーの最前線
    共立出版 2009
  • タンパク質をみる : 構造と挙動
    化学同人 2009 ISBN:9784759811636
  • タンパク質のはたらきを知る : 分子機能と生体作用
    化学同人 2009 ISBN:9784759811643
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Works (10):
  • 神経シナプスにおける接着複合体の準安定な二次元クラスター形成
    2010 -
  • リポ蛋白質受容体ファミリー分子が担う発生・分化制御シグナル伝達の構造生物学的解明
    2010 -
  • アルツハイマー病治療薬創出に向けたγセクレターゼの構造解析と機能制御
    2007 -
  • 新規タグ技術を中心とした膜蛋白質・細胞外蛋白質の高品質生産と精製システムの開発
    2007 -
  • セマフォリン及びセマフォリン受容体分子群をターゲットにした構造・機能解析と治療法開発
    2007 -
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Education (3):
  • - 1990 Tokyo Institute of Technology Graduate School, Division of Science and Engineering
  • - 1990 Tokyo Institute of Technology
  • - 1985 Tokyo Institute of Technology School of Science Dept. of Chemistry
Professional career (1):
  • 博士 (東京工業大学)
Work history (8):
  • 2012/04 - 現在 Osaka University, Institute for Protein Research, Professor
  • 2003/04/01 - 現在 Osaka University Institute for Protein Research Professor
  • 2003/04 - 2012/03 Osaka University, Institute for Protein Research, Professor
  • 2002/08 - 2003/03 Harvard Medical School, Dept of Pediatrics, Assistant Professor
  • 2003 - - 大阪大学蛋白質研究所 教授
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Committee career (2):
  • 2008 - 日本蛋白質科学会 理事
  • 2003 - 日本血栓止血学会 評議員
Awards (1):
  • 1990/06 - 財団法人手島工業教育資金団 手島記念研究賞
Association Membership(s) (4):
日本蛋白質科学会 ,  The Japanese Society on Thrombosis and Hemostasis ,  Japanese Biochemical Society ,  The Protein Society
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