Kojima Soichi

コジマソウイチ | Kojima Soichi

Affiliation and department：
Job title： Unit Leader
Other affiliations (1)：

東京医科歯科大学大学院医歯学総合研究科連携教授

Homepage URL (1)： http://www.ims.riken.jp/labo/74/index_j.html

Research keywords (7)：ビタミンA , TGF-β , トランスグルタミナーゼ , ケミカルバイオロジー , 分子腫瘍学 , 肝臓学 , B型肝炎

Research theme for competitive and other funds (8)：

2017 - 2022 次世代抗B型肝炎ウイルス薬導出に向けた創薬研究
2018 - 2020 細菌を原因としたROS経路を介する肝炎発症機構に関する研究
2018 - 2019 アルコール性及び非アルコール性脂肪性肝疾患の細菌を原因とした ROS経路を介する発症機序に関する研究
2018 - 抗IL-6受容体抗体による術後癒着抑制の分子機構検証と臨床試験への展開
2015 - 2016 TGF-β LAP断片を治療標的とした肝線維新生の診断と治療

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Papers (148)：

Furutani Y, Toguchi M, Shiozaki-Sato Y, Qin X-Y, Ebisui E, Higuchi S, Sudoh M, Suzuki H, Takahashi N, Watashi K, et al. An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS ONE. 2019. 14. 6. e0216139
Takahashi, N, Hayashi, K, Nakagawa, Y, Furutani, Y, Toguchi, M, Shiozaki-Sato, Y, Sudoh, M, Kojima, S, Kakeya, H. Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008. Bioorganic & Medicinal Chemistry. 2019. 27. 3. 470-478
Hiroshi Yokoyama, Takahiro Masaki, Ikuyo Inoue, Mariko Nakamura, Yoshihiro Mezaki, Chisato Saeki, Tsunekazu Oikawa, Masayuki Saruta, Hiroyuki Takahashi, Masahiro Ikegami, et al. Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease. Heliyon. 2019. 5. 2. e01231-e01231
Qin, X-Y, Kojima, S. Inhibition of stearoyl-CoA desaturase-1 activity suppressed SREBP signaling in colon cancer cells and their spheroid growth. Gastrointest. Disords. 2019. 1. 1. 191-200
Mengqian Li, Xian-Yang Qin, Yutaka Furutani, Ikuyo Inoue, Sanae Sekihara, Hiroyuki Kagechika, Soichi Kojima. Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β. Biochemical and Biophysical Research Communications. 2018. 504. 4. 857-864

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Patents (9)：

抗HBV剤
抗B型肝炎ウイルス薬
B型肝炎抗原タンパク質を標的とするPETプローブの開発
琥珀由来のVEGF産生促進剤及び琥珀由来のVEGF産生促進剤を含む製剤又は化粧料若しくは頭髪・頭皮用化粧料
琥珀から得られるエンドセリン-1産生抑制剤、SCF産生抑制剤、及び/又はメラニン産生抑制剤並びにその使用

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Lectures and oral presentations (17)：

Molecular mechanism of the liver-protecting effects of garlic extracts against liver injuries.
(International Garlic Symposium 2019)
新規機能的カプシド阻害cccDNA低分子化合物 CBT-078
(2019)
FibrogenesisマーカーTGF-βLAP-Dの基礎から臨床への応用
(2018)
非環式レチノイドによるタンパク質架橋酵素トランスグルタミナーゼ2の立体構造変化の誘導
(2018)
Gut dysbiosis, nuclear transglutaminase and hepatocyte death
(The 13th International Symposium on ALPD and Cirrhosis 2018)

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Works (3)：

Screening of Novel Drugs:Drug Discovery and Development of New Drugs for Hepatitis B
2012 - 現在
Development of New Diagnosis Method:Novel Liver Fibrogenesis Marker, TGF-β LAP-DP
2007 - 現在
Molecular Mechanism of Novel Drugs:Acyclic Retinoid Kills Selectively Liver Cancer Stem Cells
2003 - 現在

Education (3)：

1985 - 1990 Tokyo Institute of Technology Graduate School of Science
1982 - 1985 Tokyo Institute of Technology School of Science Dept. of Chemistry
1981 - 1985 Tokyo Institute of Technology

Professional career (1)：

Ph.D. (Tokyo Institute of Technology)

Work history (16)：

2019/02 - 現在 Medical School of Nanjing University Visiting Professor
2018 - 現在 RIKEN Liver Cancer Prevention Research Unit, Center for Integrative Medical Sciences Unit Leader
2015 - 現在 The Jikei University School of Medicine Department of Laboratory Medicine Visiting Professor
2012 - 現在 Tokyo Medical and Dental University Visiting Professor
2013 - 2017 RIKEN Micro-Signaling Regulation Technology Unit, Imaging Application Group, Division of Bio-function Dynamics Imaging, RIKEN Center for Life Science Technologies Unit Leader

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Awards (5)：

2017 - Bristrol-Myers Squibb Foundation Research Award
2015 - Terumo Foundation for Life Sciences and Arts Research Award
2012 - Uehara Memorial Foundation Research Award
2000 - Japanese Vascular Biology Meeting Fellowship
1999 - Japanese Society for Thrombosis and Hemostasis Best Poster Award

Association Membership(s) (12)：

ISHSR , AASLD , 日本トランスグルタミナーゼ研究会 , 日本レチノイド研究会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , 日本癌学会 , ASBMB(米国生化学・分子生物学会) , 日本薬学会 , 日本生化学会 , 日本分子生物学会 , The Japan Society of Hepatology

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