Hidaka Koushi

ヒダカコウシ | Hidaka Koushi

Affiliation and department：
Job title： Specially Appointed Technical Staff
Other affiliations (1)：

Kobe University Graduate School of Health Sciences Researcher

Homepage URL (1)： https://www.researchgate.net/profile/Koushi_Hidaka

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (9)： antimicrobials , infectious diseases , peptide , マラリア , HIV , プロテアーゼ阻害剤 , malaria , HIV , protease inhibitor

Research theme for competitive and other funds (14)：

2024 - 2027 選択的ジペプチジルペプチダーゼ阻害剤による糖尿病関連歯周炎に対する創薬研究
2021 - 2024 Development of a new periodontal disease drug targeting dipeptidyl peptidase
2021 - 2024 Establishment of method for detecting viral protease activity using affinity competition
2018 - 2021 Discovery of removable inhibitors targeting proteases
2016 - 2019 Discovery of INSL7 analogue with agonistic activity for RXFP3 in the brai

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Papers (55)：

Akihiro Nakamura, Nobuyuki Honma, Yuma Tanaka, Yoshiyuki Suzuki, Yosuke Shida, Yuko Tsuda, Koushi Hidaka, Wataru Ogasawara. 7-Aminocoumarin-4-acetic Acid as a Fluorescent Probe for Detecting Bacterial Dipeptidyl Peptidase Activities in Water-in-Oil Droplets and in Bulk. Analytical Chemistry. 2022. 94. 5. 2416-2424
Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Koushi Hidaka, Tsutomu Takegami. Characterization of JC Polyomavirus Derived from COS-IMRb Cells. Japanese Journal of Infectious Diseases. 2021. 74. 1. 48-53
Hidaka K, Adachi M, Tsuda Y. Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation. Bioconjugate chemistry. 2019. 30. 7. 1979-1985
Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Koushi Hidaka, Tsutomu Takegami. Establishment of COS-JC cells persistently producing archetype JC polyomavirus. Microbiology and immunology. 2018. 62. 8. 524-530
Hidaka K, Kimura T, Sankaranarayanan R, Wang J, McDaniel KF, Kempf DJ, Kameoka M, Adachi M, Kuroki R, Nguyen JT, et al. Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. Journal of medicinal chemistry. 2018. 61. 12. 5138-5153

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MISC (57)：

中村彰宏, 鈴木義之, 志田洋介, 津田裕子, 日高興士, 小笠原渉. Development of Coumarin-based Substrates for Ultra-high Throughput Droplet-based Screening of Microorganisms. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Yoshio Okada. Exploration of Active Site-Directed Plasmin Inhibitors: Beyond Tranexamic Acid. Processes. 2021. 9. 2. 329-329
福本哲也, 北條恵子, 北條恵子, 日高興士, 日高興士, 屋山勝俊, 屋山勝俊, 津田裕子, 津田裕子. Relaxin-2B鎖のステープルアナログの設計と合成. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
北條恵子, 日高興士, 市川秀喜, 津田裕子, 北條恵子, 日高興士, 市川秀喜, 津田裕子. 水中マイクロ波ペプチド固相合成~水酸基無保護下でのペプチド合成. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka. Design of new cyclic plasmin inhibitors. JOURNAL OF PEPTIDE SCIENCE. 2018. 24. S117-S118

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Patents (4)：

ペプチド型細菌ジペプチジルペプチダーゼ7阻害剤
抗菌性ジペプチド化合物
ビオチン直接結合型タンパク質活性調節物質
γ-グルタミルシクロトランスフェラーゼ阻害剤

Lectures and oral presentations (10)：

Development of antimicrobial dipeptides using X-ray crystal structures of bacterial DPP7
(CBI Annual Meeting 2020, JAXA Symposium "Results obtained from the high-quality protein crystals grown in space 2020)
感染症関連プロテアーゼのペプチドミメティクスによる制御と新たな可能性
(鈴鹿医療科学大学平成29年度第3回薬学部セミナー 2018)
ペプチドミメティクス研究の発想転換で感染症に挑む
(第8回関西バイオ創薬研究会 2017)
感染症治療薬の構造活性相関研究から気づくペプチドミメティクスの可能性
(第3回近畿支部薬学シンポジウム:化学系の若い力 2017)
アロフェニルノルスタチンを用いる感染症治療薬設計とプロテアーゼプローブへの応用
(生命分子機能研究会セミナー2013 2013)

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Education (2)：

1997 - 1999 Konan University Graduate School of Natural Science Master's Course, Chemistry
1993 - 1997 Konan University Faculty of Science Applied Chemistry

Professional career (1)：

Ph.D. (Kyoto Pharmaceutical University)

Work history (9)：

2022/05 - 現在 Kobe University Center for Supports to Research and Education Activities Project Technical Staff
2022/05 - 2024/03 Kobe University Graduate School of Health Sciences Researcher
2021/10 - 2022/04 Kobe University Graduate School of Science, Technology and Innovation Academic Researcher, AMED
2021/06 - 2022/04 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Visiting Associate Professor
2021/04 - 2022/04 Kobe University Graduate School of Health Sciences Part-time Lecturer

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Committee career (3)：

2021/09 - 現在 Japanese Society for Proteases in Pathophysiology Council
2017/11 - 2023/05 International Proteolysis Society Council
2016/01 - 2019/12 近畿エイズ研究会理事

Awards (4)：

2016/06 - 30th Annual Meeting of Kinki AIDS Society Scientific Award
2009/06 - 23th Annual Meeting of Kinki AIDS Society Scientific Award
2008/12 - International Symposium on Integrated Medicinal Science Young Investigator Award of Excellence Enhanced activity of hydroxymethylcarbonyl-containing inhibitors targeting malarial plasmepsin.
2002/08 - Conference on Proteases and Inhibitors in Pathophysiology and Therapeutics Poster Award

Association Membership(s) (10)：

The Japanese Society for Virology , American Chemical Society , 近畿エイズ研究会 , International Proteolysis Society , THE JAPANESE SOCIETY FOR AIDS RESEARCH , THE PHARMACEUTICAL SOCIETY OF JAPAN, Division of Medicinal Chemistry , THE PHARMACEUTICAL SOCIETY OF JAPAN , Japan Society for Proteases in Pathophysiology , The Japanese Peptide Society , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

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