Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (2)：
創薬
, drug discovery
Research theme for competitive and other funds (19)：
2020 - 2024 The investigation of the new small molecule inhibitors of IL-17A for intervertebral disc disease treatment by In Silico analysis
2019 - 2021 Analysis of cancer antigens through novel HLA assay
2016 - 2020 Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology
2016 - 2018 The exploration of new drug for the treatment of Notch-active tumor cells.
2015 - 2018 Development of cultured skin which has tolerance in ischemia.
2015 - 2018 In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patients
2013 - 2015 The search for HLA inhibitor using short ragweed allergy mouse model.
2010 - 2015 Integrated redearch for HLA disease and evolution
2010 - 2013 HLA分子を標的としたin silico医薬分子探索
2007 - 2011 Genome-wide identification of genes for anorexia and their cascade analysis on disease development by functional study
2007 - 2010 in silico analysis of molecular interactions between commercially available drugs in Japan and proteins
2005 - 2006 Development of novel compounds that enhance HIF activity and ameliorate chronic hypoxia in diabetic nephropathy and other diseases.
2002 - 2005 コンピュータを用いた創薬
2002 - 2005 in silico drug discovery
1999 - 2002 Structure and function of metal-binding human metallothionein
1998 - 1999 Construction of cellobiohydrolase from filamentous fungus with endo-type cleavage fashion using protein engineering
1994 - 1998 重金属を選択的にターゲティングするタンパク質分子のデザイン
1993 - 1995 Development of stable cholesterol oxidase used for diagnosis
1992 - 1994 Studies on Molecular Recognition Patterns between Sugars and Amino Acids by Use of the Data Obtained from Single Crystal X-Ray Analysis
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Papers (22)：
Ryosuke Nakamura, Takeshi Ozeki, Noriaki Hirayama, Akihiro Sekine, Taiki Yamashita, Yoichi Mashimo, Yoshiko Mizukawa, Tetsuo Shiohara, Hideaki Watanabe, Hirohiko Sueki, et al. Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients. The Journal of investigative dermatology. 2020. 140. 8. 1659-1662
Hirofumi Kashiwagi, Hitoshi Ishimoto, Sun-Ichiro Izumi, Toshiro Seki, Rihito Kinami, Asako Otomo, Kazumi Takahashi, Fuyuki Kametani, Noriaki Hirayama, Erika Sasaki, et al. Human PZP and common marmoset A2ML1 as pregnancy related proteins. Scientific reports. 2020. 10. 1. 5088-5088
