Rchr
J-GLOBAL ID：200901078357152310   Update date: Oct. 09, 2024

Hirasawa Akira

ヒラサワ アキラ | Hirasawa Akira
Affiliation and department：
Kyoto University Graduate School of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences

About Kyoto University Graduate School of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (1)： Pharmacology
Research keywords  (14)： GPR120 ,  Fatty acid receptor ,  タンパク間相互作用 ,  受容体インターナリゼーション ,  ハイスループットスクリーニング ,  マイクロアレイ ,  緑色蛍光蛋白 ,  アドレナリン受容体 ,  protein ,  receptor internalization ,  high-throuput screening ,  Microarray ,  Green Fluorescent Protein ,  adrenergic receptor
Research theme for competitive and other funds  (23)：
  • 2018 - 2022 Analysis of sperm function mediated by polyunsaturated fatty acid receptor GPR120
  • 2015 - 2017 The mechanism of NASH development via long chain fatty acid receptor GPR120/FFAR4.
  • 2011 - 2012 Elucidation of physiological role of the fatty acid receptor bycomputer simulation and the fluorescent probe detection system
  • 2010 - 2012 Search for Antidiabetic Principles from Mushrooms, Lichens, andLiverworts
  • 2009 - 2011 Physiological role of free fatty acid receptor GPR120.
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Papers (185)：
  • Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, et al. Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding. American journal of physiology. Endocrinology and metabolism. 2023. 324. 5. E449-E460
  • Yoshinori Takei, Yoko Amagase, Keiko Iida, Tomohiro Sagawa, Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Shinichi Kawai, Atsushi Sugiyama, et al. Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory. GeroScience. 2022. 44. 4. 2305-2318
  • Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-Kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa, Keisuke Yoshikawa. A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus. Journal of neuroinflammation. 2021. 18. 1. 304-304
  • Yuki Murata, Norio Harada, Shigenobu Kishino, Kanako Iwasaki, Eri Ikeguchi-Ogura, Shunsuke Yamane, Tomoko Kato, Yoshinori Kanemaru, Akiko Sankoda, Tomonobu Hatoko, et al. Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK. iScience. 2021. 24. 9. 102963-102963
  • Rina Sotome, Akira Hirasawa, Motoi Kikusato, Taku Amo, Kyohei Furukawa, Anna Kuriyagawa, Kouichi Watanabe, Anne Collin, Hitoshi Shirakawa, Ryota Hirakawa, et al. In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments. Amino Acids. 2021. 53. 3. 381-393
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MISC (105)：
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Patents (22)：
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Books (5)：
  • 脂質代謝異常と関連疾患 : 疾患モデルの作製と利用
    エル・アイ・シー 2015 ISBN:9784900487543
  • Bioactive lipid mediators : current reviews and protocols
    Springer 2015 ISBN:9784431556688
  • 薬物受容体と疾患
    医薬ジャーナル社 2002
  • DNAマイクロアレイデータ解析入門
    羊土社 2002
  • 薬物動態・作用と遺伝子多型:薬物治療法の患者個別化を目指した21世紀の新展開
    医薬ジャーナル社 2001
Lectures and oral presentations  (13)：
  • Free fatty acid receptor GPR120, physiology and drug discovery
    (Awaji-Symposium on RNA & CLOCK 2015)
  • マイクロアレイを用いたアミロイドβタンパク質による細胞死メカニズムの考察
    (第 36 回生体膜と薬物の相互作用シンポジウム 2014)
  • Free fatty acid receptor family: new therapeutic target for metabolic diseases
    (2014)
  • Fatty acid receptors as a therapeutic target for metabolic syndrome
    (2014)
  • 脂肪酸受容体GPR120の生理機能の解明と創薬
    (DM Seminar in HIROSHIMA 2013)
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Education (4)：
  • The University of Tokyo
  • 東京大学大学院
  • University of Tokyo
  • Graduate School, University of Tokyo
Professional career (1)：
  • Ph.D
Work history (8)：
  • 2007/04 - 現在 京都大学大学院薬学研究科 薬理ゲノミクス分野 准教授
  • 2002/07 - 2007/03 京都大学大学院薬学研究科 ゲノム創薬科学分野 助教授
  • 2002/03 - 2004/06 国立成育医療センター研究所 薬剤治療研究部 研究室長
  • 1997 - 国立小児病院小児医療センター小児薬理部研究員
  • 1996 - 科学技術庁長期在学研究員併任 米国Affymax
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Association Membership(s) (6)：
分子生物学会 ,  日本薬理学会 ,  日本生化学会 ,  The Molecular Biology Society of Japan ,  The Japanese Pharmacological Society ,  The Japanese Biochemical Society
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