Osada Shigehiro

オサダシゲヒロ | Osada Shigehiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (3)：発がん , エピジェネティクス・遺伝子発現 , クロマチン

Research theme for competitive and other funds (13)：

2022 - 2025 灌流型小腸-肝臓2臓器連結デバイスを用いた胆汁鬱滞肝毒性評価系の展開
2020 - 2023 Functional analysis of histone-modifying enzymes induced in the early stages of carcinogenesis and basic research on drug development
2014 - 2017 前がん病変で発現上昇するクロマチン関連因子による細胞死制御
2011 - 2013 発がん初期に発現上昇するクロマチン関連因子の細胞がん化・防御に与える影響
2008 - 2010 ヒストン関連因子の機能的相互作用の解析および細胞がん化における意義

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Papers (51)：

Ohta, Y, Wakita, H, Kawaguchi, M, Ieda, N, Osada, S, Nakagawa, H. Ratiometric assay of CARM1 activity using a FRET-based fluorescent probe. Bioorganic & Med. Chem. Lett. 2019. 29. 126728
Watanabe, K, Usami, N, Osada, S, Narimatsu, S, Yamamoto, I, Yoshimura, H. Cannabidiol metabolism revisited: tentative identification of novel decarbonylated metabolites of cannabidiol formed by human liver microsomes and recombinant cytochrome P450 3A4. Forensic Toxicol. 2019. 37. 449-455
Motoharu Goto, Shigehiro Osada, Masayoshi Imagawa, Makoto Nishizuka. FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-beta-mediated EMT in cervical cancer cells. SCIENTIFIC REPORTS. 2017. 7. 1. 1-12
OSADA, Shigehiro. Role of histone modification enzymes induced at the early stage of hepatocarcinogenesis. The Cell. 2017. 49. 8. 44-47
Makoto Nishizuka, Wataru Horinouchi, Eri Yamada, Natsuki Ochiai, Shigehiro Osada, Masayoshi Imagawa. KCNMA1, a pore-forming -subunit of BK channels, regulates insulin signalling in mature adipocytes. FEBS LETTERS. 2016. 590. 23. 4372-4380

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MISC (33)：

M. Goto, M. Nishizuka, S. Osada, M. Imagawa. The role of fad104, a positive regulator for adipogenesis, in TGF-beta 1-induced epithelial to mesenchymal transition. MOLECULAR BIOLOGY OF THE CELL. 2016. 27
M. Nishizuka, W. Horinouchi, E. Yamada, S. Osada, M. Imagawa. KCNMA1 contributes to the regulation of insulin signalling in mature adipocytes. MOLECULAR BIOLOGY OF THE CELL. 2016. 27
N. Ochiai, M. Nishizuka, S. Osada, M. Imagawa. The role of fad24, a positive regulator for adipogenesis, in early embryonic development and muscle cell activation. FEBS JOURNAL. 2015. 282. 286-286
M. Nishizuka, W. Horinouchi, E. Yamada, S. Osada, M. Imagawa. The role of KCNMA1 in mature adipocytes. FEBS JOURNAL. 2015. 282. 285-285
D. Katoh, M. Nishizuka, S. Osada, M. Imagawa. Fad104, a positive regulator of adipogenesis, inhibits invasion and metastasis of cancer cells through the suppression of STAT3 activity. FEBS JOURNAL. 2015. 282. 284-284

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Books (6)：

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Education (3)：

Professional career (1)：

Work history (4)：

2021/04 - 現在 Wakayama Medical University
2018/04 - 2021/03 Daiichi University of Pharmacy Faculty of Pharmaceutical Sciences professor
2005/06 - 2018/03 Nagoya City University Graduate School of Pharmaceutical Sciences associate professor
1994/06 - 2005/05 Osaka University Graduate School of Pharmaceutical Sciences research associate

Awards (1)：

Association Membership(s) (4)：

The Japanese Cancer Association , The Molecular Biology Society of Japan , The Japanese Biochemical Society , The Pharmaceutical Society of Japan

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