Rchr
J-GLOBAL ID：200901079323823751   Update date: Apr. 26, 2024

Hotta Akitsu

ホッタ アキツ | Hotta Akitsu
Affiliation and department：
Kyoto University

About Kyoto University


Job title： Principal Investigator (Assistant Professor)
Homepage URL  (1)： http://www.cira.kyoto-u.ac.jp/hotta/
Research field  (5)： Genomics ,  Medical biochemistry ,  Developmental biology ,  Cell biology ,  Molecular biology
Research keywords  (8)： iPS cells ,  CRISPR ,  Muscular dystrophy ,  Genome editing ,  エピジェネティクス ,  幹細胞 ,  遺伝子治療 ,  ウイルスベクター
Research theme for competitive and other funds  (13)：
  • 2022 - 2025 近傍集積因子解析よるCRISPR-Cas3ゲノム欠失誘導機構の解明
  • 2019 - 2022 Development of induciblydiversified antibody-expressing cell library that enables antibody phenotypic screening
  • 2017 - 2020 独自送達技術開発による先天性筋疾患に対するゲノム編集治療法の開発
  • 2015 - 2019 Establishment of novel gene and cell therapy for Hemophilia without viral vector
  • 2015 - 2018 Precise genomic correction by intercellular regulation of genome editing enzyme
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Papers (77)：
  • Joseph Lee, Youichi Naoe, Uikyu Bang, Yu Nakagama, Akatsuki Saito, Yasutoshi Kido, Akitsu Hotta. Neutralization sensitivity of FL.1 and GE.1 from therapeutic antibodies and seropositive XBB sera. Virology. 2024. 110067-110067
  • Misato Nakanishi-Koakutsu, Kenji Miki, Yuki Naka, Masako Sasaki, Takayuki Wakimizu, Stephanie C Napier, Chikako Okubo, Megumi Narita, Misato Nishikawa, Reo Hata, et al. CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells. Communications biology. 2024. 7. 1. 231-231
  • Ryuichiro Hirayama, Kosuke Toyohara, Kei Watanabe, Takeya Otsuki, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, et al. iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome. Communications Biology. 2023. 6. 1
  • Yuto Kita, Yuya Okuzaki, Youichi Naoe, Joseph Lee, Uikyu Bang, Natsumi Okawa, Akane Ichiki, Tatsuya Jonouchi, Hidetoshi Sakurai, Yusuke Kojima, et al. Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs. Stem Cell Reports. 2023
  • Charlotte Flahou, Tatsuya Morishima, Natsumi Higashi, Yoshikazu Hayashi, Huaigeng Xu, Bo Wang, Chaoqi Zhang, Atsushi Ninomiya, Wei-Yin Qiu, Akinori Yuzuriha, et al. Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells. Biochemical and biophysical research communications. 2023. 662. 76-83
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MISC (66)：
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Patents (6)：
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Books (6)：
  • 現代思想 2017年6月臨時増刊号 総特集◎iPS細胞の未来 -山中伸弥の仕事-
    青土社 2017 ISBN:4791713435
  • ゲノム編集成功の秘訣Q&A : 論文だけではわからない : TALEN、CRISPR/Cas9の極意
    羊土社 2015 ISBN:9784758101936
  • Targeted Genome Editing Using Site-Specific Nucleases
    Springer 2015 ISBN:9784431552277
  • 再生医療2015 幹細胞と疾患iPS細胞の研究最前線
    羊土社 2015 ISBN:9784758103442
  • Biomaterials and Regenerative Medicine
    Cambridge University Press 2014 ISBN:9781107012097
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Lectures and oral presentations  (83)：
  • ヘルマンスキー・パドラック症候群2型患者由来iPS細胞を用いて2型肺胞上皮細胞の機能異常を再現する
    (日本肺サーファクタント・界面医学会雑誌 2019)
  • ゲノム編集とiPS細胞を用いた難病治療法開発
    (金沢医科大学雑誌 2019)
  • ウイルス様粒子送達システムを用いた筋ジストロフィーのゲノム編集治療法開発研究
    (日本筋学会学術集会プログラム・抄録集 2019)
  • ヒトiPS細胞由来肺胞オルガノドを用いたHermansky-Pudlak症候群2型の疾患モデリング
    (組織培養研究 2019)
  • ゲノム編集が加速するiPS細胞研究と筋ジストロフィー治療への挑戦
    (日本医学会総会会誌 2019)
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Education (2)：
  • 2001 - 2006 Nagoya University
  • 1997 - 2001 Nagoya University School of Engineering
Professional career (1)：
  • 工学博士(生物工学) (名古屋大学)
Work history (9)：
  • 2022/05 - 現在 Center for iPS cell Research and Application, Kyoto University Department of Clinical Application Associate Professor
  • 2016/04 - 現在 T-CiRA Program Hotta Project Project Leader
  • 2020/10 - 2022/04 Center for iPS cell Research and Application, Kyoto University Department of Clinical Application Junior Associate Professor
  • 2018/04 - 2020/09 Center for iPS cell Research and Application, Kyoto University Department of Clinical Application Juniro Associate Professor
  • 2016/10 - 2018/03 Center for iPS cell Research and Application, Kyoto University Department of Life Science Frontiers Junior Associate Professor
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Committee career (16)：
  • 2023/04 - 現在 Japanese Society for Regenerative Medicine. Director
  • 2021/05 - 現在 日本ゲノム編集学会 第七回年会 大会長
  • 2021/04 - 現在 名古屋大学教育学部附属中学・高等学校 WWL運営指導委員
  • 2020/07 - 現在 Japan Society for Genome Editing Director
  • 2016/07 - 現在 日本ゲノム編集学会 倫理および規制に関する委員会 委員長
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Awards (3)：
  • 2020/05 - Japanese Society for Regenerative Medicine Japanese Society for Regenerative Medicine Award (Basic Research)
  • 2016/04 - The Commendation for Science and Technology by the Minister of MEXT The Young Scientists’ Prize The Young Scientists’ Prize
  • 2009 - SickKids Exceptional Trainee Award
Association Membership(s) (7)：
日本筋学会 ,  THE JAPANESE SOCIETY OF GENOME EDITING ,  American Society for Gene and Cell Therapy (ASGCT) ,  International Society for Stem Cell Research (ISSCR) ,  JAPAN SOCIETY OF GENE AND CELL THERAPY ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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