Kurokawa Hirofumi

クロカワヒロフミ | Kurokawa Hirofumi

Affiliation and department：
Job title： Lecturer

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (10)：

2023 - 2026 Next Generation Crystal Structure Analysis by Cryo-Electron Microscopy
2013 - 2015 酸化ストレスセンサーと選択的蛋白質分解系によるシグナリング複合体の構造と機能
2011 - 2013 酸化ストレスセンサーKeap1と選択的蛋白質分解系による新規シグナリング複合体
2009 - 2011 hree-dimensional Structure of Nrf2-Maf transcription factor complex mediating the induction of phase II detoxifying enzymes
2007 - 2011 Molecular Mechanisms of Adaptive Responses to Food and Oxygen

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Papers (33)：

Hirofumi Kurokawa, Saori Maki-Yonekura, Kiyofumi Takaba, Toshiki Higashino, Satoru Inoue, Tatsuo Hasegawa, Koji Yonekura. 3D Electron Diffraction Structure of an Organic Semiconductor Reveals Conformational Polymorphism. Journal of the American Chemical Society. 2025
Toshiki Higashino, satoru inoue, Shunto Arai, Seiji Tsuzuki, Hiroyuki Matsui, Reiji Kumai, Kiyofumi Takaba, Saori Maki-Yonekura, Hirofumi Kurokawa, Ichiro Inoue, et al. Effects of Thiophene-Fused Isomer on High-Layered Crystallinity in π-Extended and Alkylated Organic Semiconductors. Chemistry of Materials. 2024
Hirofumi Kurokawa, Takanori Ambo, Seiji Takahashi, Tanetoshi Koyama. Crystal structure of Thermobifida fusca cis-prenyltransferase reveals the dynamic nature of its RXG motif-mediated inter-subunit interactions critical for its catalytic activity. Biochemical and Biophysical Research Communications. 2020
Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, et al. Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. The Journal of biological chemistry. 2015. 290. 17. 10644-10644
Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I. Tong, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. NATURE CELL BIOLOGY. 2010. 12. 3. 213-U17

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MISC (26)：

KUROKAWA Hirofumi. Structure function relatioship of Keapl as chemical sensor. 2013. 85. 8. 663-670
Atsushi Hasegawa, Ritsuko Shimizu, Hirofumi Kurokawa, Masayuki Yamamoto. DNA Binding Diversity Achieved Through the Interaction of GATA1 N-Finger and GATA Motif Is Important for Embryonic Erythropoiesis. BLOOD. 2012. 120. 21
黒河博文, 山本雅之. 酸化ストレスセンサー分子Keap1 (血管医学). 血管医学. 2011. 12. 4. 23-30
Hirofumi Kurokawa, Masayuki Yamamoto. Structural Basis for the Inactivation of Stress Sensor Keap1 by Selective Autophagy Substrate p62. (Photon Factory Activity Report 2009). Photon Factory Activity Report 2009. 2010. 56-57
Hirofumi Kurokawa. 酸化ストレスセンサーKeap1と選択的オートファジー基質p62複合体の結晶構造解析 (日本結晶学会誌). 日本結晶学会誌. 2010. 52. 5. 250-254

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Books (2)：

Lectures and oral presentations (8)：

Structural determination of water-soluble gold cluster by cryo-electron microscopy
(38th conference of European Colloid & Interface Society (ECIS2024) 2024)
水溶性配位子保護金クラスターの構造決定におけるクライオ電子顕微鏡の導入
(ナノ学会第22会大会 2024)
放射光で解析困難なナノ有機結晶の構造解析-クライオ電顕+3D ED解析による構造解析-
(東北大学ソフトマテリアル研究拠点会議 2022)
Ph-BTBTT-Cn系有機半導体の分子構造異性による結晶構造の転換
(応用物理学会春季学術講演会 2022)
cis型プレニル基転移酵素の構造ダイナミクス
(第29回イソプレノイド研究会 2019)

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Education (3)：

- 1996 Kyoto University Graduate School, Division of Agricultural Science Department of Food Science and Technology
- 1993 Kyoto University Graduate School, Division of Agriculture Department of Food Science and Technology
- 1991 Kyoto University Faculty of Agriculture Department of Food Science and Technology

Professional career (2)：

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